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Diabetes is a complex of disorders characterized by a common final element of hyperglycemia and vascular injury. The pathogenetic differences between type 1 and 2 diabetes are universally recognized, as are the emerging subdivisions of non-insulin dependent diabetes or NIDDM. Common to these is a need to understand the diverse molecular mechanisms that lead to hyperglycemia. Diabetes, arising from differing initiating lesions, shares complications, which occur frequently and exact a heavy toll on patients and families.
The Diabetes Center operates in the belief that applying the increasingly sophisticated biochemical, physical and molecular biologic tools available to problems relating to the origin of diabetes or its complications will improve the lives of patients with diabetes or patients at risk to developing the disease.
The vision of the Diabetes Center is two-fold.
First, through the Assay Core Laboratories, the Center seeks to implement and if need-be develop for members state-of-the-art methods for studying the pathogenesis and complications of diabetes. Through the Pilot and Feasibility Program and Enrichment Program, the Center seeks to inform other researchers of the nature of the biologic and clinical problems encompassed by diabetes and challenge them to use their research skills to investigate these problems in diabetes.
Diabetes Center Core Laboratories
The research focus of the Diabetes Center members includes:
- Pancreatic Islet Biology and Genetics
- The Control of Plasma Glucose in the Clinical Environment
- Insulin Action and Resistance
- Diabetes Complications
The Diabetes Center has previously been supported in part by a Diabetes Endocrine Research Center (DERC) grant from the NIDDK of the NIH.