Shared Facilities

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Shared Facilities

Research Core Facilities. The School of Medicine supports several state-of-the-art core facilities that are available to investigators on a fee-for-service basis. These facilities are administered by Jay W. Fox, Ph.D., Assistant Dean for Research Support, and an advisory committee. Each core is overseen by a faculty committee; the SOM Research Advisory Committee (RAC) recommends annual subsidies to the Dean.

  • Advanced Microscopy Facility. The Advanced Microscopy Core (AMC) provided expertise, training and instrumentation associated with confocal and electron microscopy (TEM and SEM). Sample preparation and operation of core instrumentation can be performed by core staff or trained users.
  • Biomolecular Research Facility. The Biomolecular Research Facility is divided into two program areas: Mass spectrometry/Proteomics and DNA Sciences. The Mass Spectrometry/Proteomics area supports experimentation in protein identification, post-translational modification analysis, binding partner/complex mixture analysis and quantitative mass spectrometry utilizing iTRAQ and SILAC approaches. The DNA Sciences Laboratory offers gene expression profiling by Affymetrix platforms, genomic analysis using a Solexa analyzer and DNA sequencing.
  • BioNMR Core (Contact Jeff Ellena, Laboratory Director or Dr. John Bushweller, Faculty Director). The BioNMR Core has two NMR spectrometers (600MHz and 800MHz) for use by trained investigators or core staff. Expert consultation in molecular structural elucidation and molecular dynamics is available.
  • Biorepository and Tissue Research Facility. This resource provides prospective and banked human tissue procurement; processing and storage of all types of biospecimens including blood, urine and tissues; enzymatic dissociation and freezing of tissue samples; and extraction of nucleic acids and proteins from tissues. Laser microdissection, immunohistochemistry and tissue microarray production are also available.
  • Flow Cytometry Core Facility. The core maintains a variety of cell sorters and analyzers for state of the art cellular characterization. Expert consultation is available for experimental design and instrumentation is available for use by trained investigators or experiments can be performed by the staff. Several training/educational programs are offered throughout the year for investigators, students and staff.
  • Gene Targeting and Transgenic Facility. The range of services offered by the GTTF include genetic engineering of mutant mice; genetic analysis of mutant mouse strains and cryopreservation of mutant lines. The facility offers a yearly educational workshop to train investigators and staff in technologies associated with genetic manipulation of mice.
  • Lymphocyte Culture Center. The primary function of this core is to construct and select lymphocyte-myeloma hybridomas for the production and purification of monoclonal antibody reagents as well as expert consultation on experimental design leading to monoclonal production and antibody
    characterization.
  • Molecular Imaging Core. The aim of the core is to provide noninvasive monitoring of biological processes in vivo using a variety of anatomical and functional imaging modalities. Additionally development of targeted imaging agents is available. Instrumentation for the modalities of X-Ray CT, MRI, PET, SPECT and bioluminescence are available. A cyclotron will be in place within the near future.
  • MolMart. This facility provides common molecular biological reagents and supplies for purchase and delivery to investigator laboratories. Reagent pick-up at the site is also available.
  • Research Histology Core. The Research Histology Core offers high quality, high throughput histology services including routine embedding, sectioning and H and E and special staining protocols. This core works in close affiliation with the BTRF to coordinate efforts to support investigators.
  • Tissue Culture Core. Services provide by the Tissue Culture Core include cell line culture, propagation and storage as well as primary cell culture and baculovirus production. A variety of cell culture reagents are available in the laboratory for investigator purchase.
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