Mark H. Stoler, MD
Analysis of gene expression in cancer tissues for diagnosis
Research in the Stoler laboratory is directed at the application of molecular biologic methods, primarily in situ hybridization. pcr and immunohistochemistry, to the study of gene expression in human disease emphasizing carcinogenesis. Areas of active investigation include viral carcinogenesis using the cervical cancer paradigm, and the modulation of cellular gene expression in a variety of neoplastic and inflammatory states with direct application to gynecologic and hematolymphoid malignancies. Active collaborations are extending these approaches to the study of gene expression in the areas of developmental biology, as well as the pathogenesis of autoimmune diseases. Refinement of the role of these molecular methods as diagnostic and or prognostic adjuncts to anatomic pathology and oncology practice is also under active investigation.
In addition to these more basic studies, the lab is also actively involved in clinical trials directed at the application of new technology to gynecologic cytopathology. These include clinical trials using liquid based cytology samples for adjunctive molecular testing, evaluation of cytology automation systems, evaluation of diagnostic adjunct instruments for colposcopy, and the development of prophylactic HPV vaccines.