Kyle Hoehn, PhD
Cellular lipid availability has pathogenic and prognostic significance for many cancers. Approximately 20% of cancers in the US are directly linked to obesity; however the precise mechanism remains unclear. Our lab investigates the role of fat metabolism in cancer cell growth and proliferation. Specifically, we investigate two major lipid metabolic pathways in cancer cells; fatty acid oxidation (FAO) and de novo lipogenesis (DNL). Cancer cells have cell-type specific regulation of FAO and rely heavily on DNL. Our overarching mission is to use pharmacology and genetics to selectively interrupt the lipid metabolism pathways that are necessary for cancer cell proliferation and survival while sparing normal cells and tissues.