Alexander L. Klibanov, PhD
Targeted delivery of therapeutic and diagnostic imaging agents
My research interest in cancer-related activities is based on the combination of targeted imaging and drug delivery; most of the effort is combined based on the application of ultrasound contrast agents (microbubbles). We have microbubble contract agents, that, after intravenous injection, can achieve selective targeting to the specific markers that are upregulated on the vascular endothelium in the tumor neovasculature (such as VEGF Receptor 2 and VCAM-1). We also prepare contrast materials that help evaluate perfusion in the tumor setting; ultrasound imaging allows to monitor in real time the movement of these particles with picogram mass through the tumor vasculature deep within the tumor (cm depth).
On the drug delivery and tumor therapy effort, the direction of my R33 grant (NCI) is the preparation and characterization of microbubble-based drug delivery systems that provide ultrasound-triggered release of anticancer agents in the insonated tumor zone, as well as triggered thrombin release for targeted clotting of tumor vasculature.