Amir Jazaeri, MD
Biomarkers and signaling in gynecologic cancers
The broad research goal in the Jazaeri lab is to gain a better understanding of the molecular and cell biology of gynecologic cancers with an emphasis on clinically relevant endpoints for translational application. The first main focus area of investigation is the development and validation of biological markers for the diagnosis and early detection of ovarian cancers. Genomic and proteomic approaches are being used in conjunction with standard molecular biology techniques for the evaluation of new biomarkers and their clinical and biologic relevance in ovarian cancer. In particular, proteomic protocols for evaluation of potential markers in saliva are being developed in conjunction with Dr. Kristen Atkins in the Department of Pathology. Molecular signaling in endometrial cancer is another focus area. In collaboration with Dr. Laurel Rice, signaling targets with potential therapeutic value have been identified in well-differentiated and aggressive (MMMT and grade 3 endometrioid) histologic subtypes of endometrial cancer and we plan to initiate clinical trials aimed at these targets. A third focus area, which is currently under development, is the investigation of improved imaging strategies using information obtained from biomarker investigations.