Jennifer A. Harvey, MD
Prognostic indicators for breast cancer based on imaging
Estrogens and progesterones increase mammographic breast density, while tamoxifen and raloxifene, which act as anti-estrogens in the breast, decrease density. Women with mammographically dense breast tissue are known to be at increased risk for breast cancer, regardless of hormone use. Following the degree of mammographic breast density may be useful as an indicator of breast cancer risk. The increase in risk from increased breast density may be mediated through overactive aromatase converting steroids to estrogen within the breast tissue. This work is supported through a supplement to Dr. Richard Santen's R01 grant, and a Department of Defense grant.