Sheila E. Crowe, MD
Oxidative stress in inflammation and epithelial cell damage in digestive tract the mucosa, and its relationship to gastric cancer
The Crowe laboratory has utilized tools of cell and molecular biology to understand the role of oxidative stress in promoting inflammation and damage in the mucosa of the digestive tract. One model that is of particular relevance to gastric cancer is the H. pylori infection. H. pylori is a known gastric pathogen that promotes gastric cancer largely through its ability to induce inflammation. Their work has examined the role of a multifunctional DNA repair enzyme in the control of inflammation and epithelial cell damage.
Dr. Crowe has collaborated with several investigators interested in gastric cancer that now constitute the Gastric Cancer Working Group. This group has been active since 2001 and includes Drs. El-Rafai, Ernst, Powell, Roche, Smith and Zaika. Dr. Crowe has maintained the TFF1-deficient mice and used them in experiments to examine the effects of inflammation on epithelial cell growth abnormalities. Dr. Crowe has very close collaborations with Drs. Ernst and Smith that have led to successful grant applications and co-authored publications.