Research Retreat - lunch roundtable discussion sessions
Regeneration and stem cells
An opportunity for the UVA scientific community who are interested in this topic to discuss scientific opportunities. Because it is an initial meeting, no specific topics are preplanned, rather the interests of those attending should drive the direction of the discussion.
Helen Cathro, Stephen Culp
The goal of this session is to discuss the latest translational research dealing with all types of genitourinary cancers with a special emphasis on prostate, bladder, and kidney cancer. The target audience would be urologists, pathologists, radiation oncologists, and medical oncologists. The main focus is to discuss and define potential areas of collaboration dealing with translational research including the use of xenograft tumor models and tissue microarrays, biomarker studies, and ultimately clinical trials. The participant would develop a better understanding of the resources available for studying GU cancer at UVA, as well as potential areas for improvement using a multi-disciplinary approach.
How to enable basic science targets to bedside with efficient drug discovery infrastructure
How to initiate, foster, and proliferate opportunities present here at UVA to enable early scientific discovery to patentable therapeutics.
Glucose control: from intensive care to the ambulatory artificial pancreas
Kenneth Brayman, Anthony McCall, Boris Kovatchev
In the hospital setting, the extent and magnitude of blood glucose fluctuations has been associated with mortality in a number of conditions, including but not limited to MI, stroke, and trauma. In diabetes, tight blood glucose control is the primary goal of any therapeutic intervention. Regardless of the setting, glucose control relies on monitoring and drug (primarily insulin) delivery technologies. In this session we review recent achievements in this field, ranging from in-clinic glucose control to ambulatory artificial pancreas suited for outpatient use in diabetes. Target audience: anyone in clinical, scientific, information technology or engineering disciplines who have to deal with these issues.
Virology at UVA
The goal of this session is to bring together virologists from multiple departments to discuss areas of mutual interest and potential collaborations.
Big data: challenges and opportunities for SOM-SEAS collaboration
Kevin Skadron, Fred Epstein
"Big Data" poses massive challenges that span many disciplines. The sheer volume of data requires new computer engineering capabilities as well as new algorithms that can scale to massive data sets. Privacy and security are essential in managing many types of data. Many departments in SEAS have expertise that can help SOM faculty advance their data analysis capabilities, while SOM's needs will almost certainly pose interesting new research challenges for SEAS faculty. Both SOM and SEAS would benefit from a concerted effort to connect SEAS capabilities with SOM interests and vice versa, starting by highlighting the many already successful collaborations. To kick-start collaboration and boost Big Data capabilities, this session will focus on SOM-SEAS collaborations. The session will start with short presentations about existing collaborations related to Big Data, followed by a guided discussion of needs and opportunities for advancing SEAS-SOM collaborations in this area. In preparation for the retreat, additional documentation will be collected on current SOM-SEAS collaborations and individuals' areas of expertise in order to both create a passive directory and initiate an active collaboration connection mechanism."
Nanomedicine and drug delivery systems
Alexander Klibanov, John Hossack, Brent French
The purpose of this roundtable is to find possible synergies and collaborative potential for researchers interested in drug delivery approaches and applications.
Tumor microenvironment: inflammation, immune system, and metastasis
Janet Cross, Amy Bouton, Vic Engelhard
The goal of this session is to identify new areas of scientific overlap among investigators studying host-mediated microenvironmental contributions to tumor progression and metastasis with a goal of fostering new collaborations.
Stuart Berr, Kimberly Kelly, Patrice Rehm
UVa is in the process of building a world-class molecular imaging program. Noninvasive molecular imaging provides a means by which to assess biological processes, which can be very useful for not only basic research studies but also clinically for detecting, diagnosing, and staging human disease. As imaging is useful for a wide variety of disciplines, we believe our center forms a nexus between disciplines including but not limited to the newly established UVa Centers of Excellence in Neuroscience, Cancer, and Cardiovascular disease. The round table discussion will be useful to those interested in (1) using molecular imaging to enhance translation research at UVa through the development of novel imaging radiotracers and testing them in first-in-human studies; (2) leveraging existing relationships and developing new relationships with pharmaceutical and biotechnology companies to pre-clinically and clinically test novel radiotracers; and (3) testing of new therapies using the results of established molecular imaging as an endpoint.
Data analysis and management challenges for comparative effectiveness and translational research at UVA
Ruth Bernheim, Jae Lee, George Stukenborg, James Harrison
Participants in this session will discuss biostatistical and data management challenges and issues when submitting research grant proposals. The target audience would be any interested clinical or basic science faculty.
Entrepreneurism and technology transfer at UVA: connections and partnerships
Mark Crowell, Michael Straightiff