Hammarskjöld Publications

Hammarskjöld Publications

Myles Thaler Center

  • Ward AM, Rekosh D, Hammarskjöld ML. (2009) Trafficking through the Rev/RRE pathway is essential for efficient inhibition of human immunodeficiency virus type 1 by an antisense RNA derived from the envelope gene.J Virol. 2009 Jan;83(2):940-52. PMCID: PMC2612364

  • Legiewicz M,  Badorrek B., Turner K., Fabris D. , Hamm T., Rekosh D., Hammarskjöld M-L  and Le Grice S. (2008) Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element Proc Natl Acad Sci, Proc Natl Acad Sci U S A. Sep 23;105(38):14365-70. PMCID: PMC2567145

  • Shuck-Lee D, Chen FF, Willard R, Raman S, Ptak R, Hammarskjöld ML, Rekosh D. (2008)
    Identification of Heterocyclic Compounds that Inhibit Rev-RRE Function and Human Immunodeficiency Virus Type-1 Replication. Antimicrob Agents Chemother. Sep;52(9):3169-79. PMCID: PMC2533482

  • Olivieri KC, Scoggins RM, Broderick B, Chmura M, Alexander MA, Hammarskjöld ML, Rekosh D, Camerini D.(2008) Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142. Retrovirology.  May 29;5(1):42. PMCID: PMC2440386

  • Medeiros MS, Arruda EA, Guerrant RL, Brown C, Hammarskjöld ML, Rekosh D, Lima AA. (2007) Genotype testing and antiretroviral resistance profiles from HIV-1 patients experiencing therapeutic failure in northeast            Brazil. Braz J Infect Dis.  Aug;11(4):390-4.

  • Swartz JE, Bor YC, Misawa Y, Rekosh D, Hammarskjöld ML. (2007) The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a CTE. J Biol Chem. 282 19844-19853

  • Olivieri, K.C. BS, Scoggins, R. M., Bor, Y-C, Matthews, A., Mark, B.S. ,Taylor, J., Chenauskas, D., Hammarskjöld, M-L. , Rekosh D. and Camerini D. (2007) The Envelope Gene is a Cytopathic Determinant of CCR5 Tropic HIV-1, Virology 358 23-38

  • Bessong PO, Mphahlele J, Choge IA, Obi LC, Morris L, Hammarskjöld ML, Rekosh DM. (2006) Resistance Mutational Analysis of HIV Type 1 Subtype C among Rural South African Drug-Naive Patients Prior to Large-Scale Availability of Antiretrovirals. AIDS Res Hum Retroviruses. 12 1306-1312

  • Levesque L, Bor YC, Matzat LH, Jin L, Berberoglu S, Rekosh D, Hammarskjöld ML, Paschal BM. (2006) Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.Mol Biol Cell. 17 931-43. PMCID: PMC1356601

  • Bor YC, Swartz J, Morrison A, Rekosh D, Ladomery M, Hammarskjöld ML. (2006) The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron. Genes Dev.  20 1597-1608. PMCID: PMC1482480

  • Li, Y. Bor, Y.-C.,Misawa, Y, Xue, Y, Rekosh , D.,and  M.-L.  Hammarskjöld (2006) The Tap/NXF1 Gene Contains a Functional CTE in an Intron that is Retained in an Alternatively Spliced mRNA, Nature 2006 443 234-237

  • Forrest ST, Barringhaus KG, Perlegas D, Hammarskjöld ML, McNamara CA. (2004) Intron retention generates a novel Id3 isoform that inhibits vascular lesion formation. J Biol Chem. 279 32897-32903

  • Alexander M, Bor YC, Ravichandran KS, Hammarskjöld ML, Rekosh D. (2004) Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity J Virol.  781685-96. PMCID: PMC369412

  • Coyle JH, Guzik BW, Bor YC, Jin L, Eisner-Smerage L, Taylor SJ, Rekosh D, Hammarskjöld ML. (2003) Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.Mol Cell Biol.  23 92-103. PMCID: PMC140664

  • Jin L, Guzik BW, Bor YC, Rekosh D, Hammarskjöld ML. (2003) Tap and NXT promote translation of unspliced mRNA.Genes Dev 17 3075-86. PMCID: PMC305259

  • Mierisch CM, Wilson HA, Turner MA, Milbrandt TA, Berthoux L, Hammarskjöld ML, Rekosh D, Balian G, Diduch DR. (2003) Chondrocyte transplantation into articular cartilage defects with use of calcium alginate: the fate of the cells.J Bone Joint Surg Am. 85-A(9):1757-1767.

  • Matsumura ME, Li F, Berthoux L, Wei B, Lobe DR, Jeon C, Hammarskjöld ML, McNamara CA.(2001) Vascular injury induces posttranscriptional regulation of the Id3 gene: cloning of a novel Id3 isoform expressed during vascular lesion formation in rat and human atherosclerosis. Arterioscl Thromb Vasc Biol. 21:752-8.

  • Walk,S.F., Alexander, M., Hammarskjöld,M.-L., Rekosh, D.M.and Ravichandran, K.S. (2001) Design and Use of an Inducibly-Activated HIV-1 Nef to Study Immune Modulation, J. Virol., J Virol. 75:834-843. PMCID: PMC113979

  • Guzik, B.W., Levesque, L.,Prasad, S, .Bor, Y.-C., Black, B.E.,  Paschal, B., Rekosh, D. and Hammarskjöld,M.-L.,(2001) NXT1/p15 is a Crucial Cellular Cofactor in TAP Dependent Export of Intron-Containing RNA in Mammalian Cells, Mol Cell Biol.21:2545-2554. PMCID: PMC86886

  • Chazal N, Singer G, Aiken C, Hammarskjöld ML, and Rekosh D.(2001) Human Immunodeficiency Virus Type 1 Particles Pseudotyped with Envelope Proteins That Fuse at Low pH No Longer Require Nef for Optimal Infectivity. J Virol.75 4014-4018. PMCID: PMC114896

  • Hammarskjöld ML.(2001) Constitutive transport element-mediated nuclear export. Cur Top Micro.Im.259:77-93

  • Lévesque,L. Guzik, G, Guan, T., Coyle,J. Black, B.E.,  Rekosh,D. Hammarskjöld, M.-L. and Paschal, B.M. (2001) RNA export mediated by tap Involves NXT1-dependent interactions with the nuclear pore complex J. Biol. Chem. 276 44953-44962.

  • Chien ML, Hammarskjöld ML. (2000) Epstein-barr virus latent membrane protein (LMP1) induces specific NFkappaB complexes in human T-lymphoid cells. Virus Res. 67 17-30.

  • Bishop GG, Wiegman P, McNamara C, Din S, Sanders J, Hesselbacher S, Feldman M, McPherson JA, Humphries JE, Hammarskjöld ML, Gimple LW, Ragosta M, Powers ER, Dickek D, Owens GK, Sarembock IJ. (1999) Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model. J Vasc Res. 1999 Sep-Oct;36(5):343-52

  • Helga-Maria, C., Hammarskjöld, M-L. and  Rekosh, D. (1999) An Intact TAR Element and Cytoplasmic Localization Are Necessary for Efficient Packaging of HIV Type 1 Genomic  RNA. J. Virol. 73:4127-4135. PMCID: PMC104192

  • Hamm, T. E., Rekosh, D. and Hammarskjöld, M-L. (1999) Selection and Characterization of HIV-1 Mutants that are Resistant to Inhibition by the Transdominant Negative RevM10 Protein. J. Virol., 73:5741-5747. PMCID: PMC112634

  • Ernst, R.K., Bray, M., Rekosh, D. and Hammarskjöld, M.-L. (1997) A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA Mol. Cell Biol 17: 135-144. PMCID: PMC231737

  • Ernst, R.K., Bray, M., Rekosh, D. and Hammarskjöld, M.-L. (1997), Secondary structure and mutational analysis of the Mason-Pfizer monkey virus RNA constitutive transport element.  RNA, 3: 210-222 . PMCID: PMC1369474

  • Pasquinelli, A. E., Ernst, R. K., Lund,E., Grimm, C., Zapp, M. L., Rekosh,D., Hammarskjöld, M.-L. and Dahlberg, J.E. (1997) The Constitutive Transport Element (CTE) of Mason-Pfizer Monkey Virus (MPMV) Accesses a Cellular mRNA Export Pathway, EMBO J. 16: 7500-7510Hammarskjöld, M-L (1997) Regulation of retroviral RNA transport ,Sem. Cell. Develop. Biol., 8:83-90. PMCID: PMC1170349

  • Srinivasakumar, N., Chazal, N., Helga-Maria, C., Prasad, S., Hammmarskjöld, M.-L., and Rekosh, D (1997). The effect of viral regulatory protein expression on gene delivery using human immunodeficiency virus type 1 vectors produced in stable packaging cell lines J. Virol 71:5841-5848. PMCID: PMC191839

  • Hammarskjöld ML. (1997) Regulation of retroviral RNA export. Semin Cell Dev Biol. Feb;8(1):83-90.

  • Dundr, M. Leno, M., Lewis, N., Rekosh, D., Hammarskjöld, M.L. and Olson, M. O.J. (1996) Location of the HIV-1 rev protein during mitosis: Inactivation of the nuclear export signal alters the pathway for postmitotic reentry, J. of Cell Sci.,109:2239-2251.

  • Orsini, M.J., Thakur, A.N., Andrews, W.W., Hammarskjöld, M.-L. and Rekosh, D.M. (1995) Expression and purification of the HIV-1 Rev protein and its use in the generation of monoclonal antibodies. AIDS Research and Human Retroviruses, 11: 945-953.

  • Srinivasakumar, N., Hammarskjöld, M.-L., and Rekosh, D.M. (1995) Characterization of Deletion Mutations in the Capsid Region of Human Immunodeficiency Virus Type 1 That Affect Particle Formation and Gag-Pol Precursor Incorporation. J. Virol. 69: 6106-6114. PMCID: PMC189507

  • Berkowitz, R. D., Hammarskjöld, M.-L., Helga-Maria, C., Rekosh, D. and Goff, S. P. (1995) 5' Regions of HIV-1 RNAs Are Not Sufficient for Encapsidation: Implications for the HIV-1 Packaging Signal. Virology 212: 718- 723.

  • Dundr, M., Leno, G. H., Hammarskjöld, M.-L., Rekosh, D., Helga-Maria, C. and Olson, M. O. J. (1995) The roles of nucleolar structure and function in the sub cellular location of the HIV-1 Rev protein. J. of Cell Sci.

  • Mak, J., Jiang, M., Wainberg M.A.,Hammarskjöld, M.-L., Rekosh, D. and Kleiman, L.(1994) Role of Pr160 in mediating the selective incorporation of tRNAlys into HIV-1  particles J. Virol. 68: 2065-2072. PMCID: PMC236680

  • Ciccarelli, R.B., Winter, L.A., Lorenz, R., Harris, A.L., Crawford, A.C., Bailey, T.R., Singh, B., Hammarskjöld, M. L., Rekosh, D. and Hughes, J.V. (1994) Inhibition of the cellular rev response and HIV-1 replication by 8-alkyl-2-(4-pyridyl)pyrido[2,3-d]pyrimidin-5(8H)-ones. Antiviral Chem and Chemo, 5,169-175.

  • Hammarskjöld ML, Li H, Rekosh D, Prasad S. (1994) Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron. J Virol. 1994 68 951-958. PMCID: PMC236533

  • Bray, M., Prasad, S.  Dubay, J.W., Hunter, E. Jeang,K.T., Rekosh, D. and Hammarskjöld-M-L. (1994) A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad.Sci.(USA)  91: 1256-1260. PMCID: PMC43136