Studies for Adolescents

Studies for Adolescents

Polycystic Ovary Syndrome

Studies for Adolescents

Study #1:
ABNORMAL OVARIAN FEEDBACK IN HYPERANDROGENEMIA/OBESITY
(IRB-HSR# 8588)

  • The goal of this study is to determine how testosterone modifies control of GnRH pulse secretion by ovarian steroids.
  • We are recruiting girls at all Tanner Stages (breast) 1-5 who are hyperandrogenemic
  • This study requires 3 brief outpatient visits and two 14-hour overnight admissions (5pm-7am).
  • Participants will take physiologic oral doses of estrogen and progesterone for 7 days.
  • Compensation is a $200 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information.


Study #2:
EVOLUTION OF HYPOTHALAMIC SENSITIVITY TO OVARIAN STEROID FEEDBACK IN EARLY PUBERTY
(IRB-HSR# 14100)

  • The goal of this study is to determine how the natural rise in testosterone during normal female puberty modifies control of GnRH pulse secretion by ovarian steroids.
  • We are recruiting normal premenarcheal (Tanner 1-3) girls, 8 to 14 years of age.
  • This study requires three outpatient visits and two 14-hour overnight admissions (5pm-7am).
  • Participants will take physiologic oral doses of estrogen and progesterone for 7 days.
  • Compensation is a $200 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information.

 

Study #3:
SLEEP RELATED HORMONE SECRETION THROUGH PUBERTY AND IN HYPERANDROGENEMIA
(IRB-HSR# 13502)

  • The goal of this study is to assess day-night patterns of hormone secretion (testosterone, estradiol, progesterone, LH, and FSH), during puberty in normal weight and obese girls.
  • We are recruiting girls 7 to 18 years of age.
  • This study involves one brief outpatient visit and one overnight admission (15 or 20 hours).
  • No study medications.
  • Compensation is a $100 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information.

 

Study #4:
OVARIAN CONTROL OF LH PULSES DURING MID TO LATE PUBERTY
(IRB-HSR# 13717)

  • The goal is to assess whether elevated levels of testosterone influences suppression of LH pulses by progesterone.
  • We are recruiting girls who are Tanner stage 3-5 (and ≤ 4 years post-menarche).
  • This study requires 3 brief outpatient visits and two 20-hour (overnight) admissions (4pm-noon).
  • Subjects will take four oral doses of placebo and four oral doses of physiologic progesterone.
  • Sleep is formally monitored during admissions.
  • Compensation is a $250 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information.

Study #5:
ADRENAL and OVARIAN CONTRIBUTION TO HYPERANDROGENEMIA IN NORMAL AND OBESE GIRLS
(IRB-HSR# 12702 and #15298)

  • The goal of this study is to determine the role of the adrenal glands and the ovaries in hormone production during puberty.
  • We are recruiting normal and obese girls, 7 to 18 years of age.
  • This study requires 3 brief outpatient visits and one 15-hour admission (5pm-8am).
  • Subjects will take one oral dose of dexamethasone, one IV administered dose of ACTH, and one IV administered dose of rHCG.
  • Compensation is a $200 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information.

 

Study #6:
NEUROENDOCRINE EFFECTS OF METFORMIN TREATMENT IN ADOLESCENT HYPERANDROGENEMIA
(IRB-HSR# 13789)

  • The goal of this study is to assess if metformin induced reduction in insulin normalizes the hypothalamic effects of elevated androgens in adolescent girls.
  • We are recruiting hyperandrogenemic girls, 10 to 17 years of age.
  • This study requires 6 brief outpatient visits and four 16-hour (overnight) admissions (5pm-9am).
  • Subjects will have 2 OGTTs (oral glucose tolerance tests), take metformin for approximately 3 months, and take physiologic oral doses of estrogen and progesterone for a total of 14 days.
  • Compensation is a $400 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information


Study #7:

HYPERANDROGENEMIA IN OBESE PERIPUBERTAL GIRLS: ROLE OF INSULIN AND LH
(IRB-HSR# 13552)

  • The goal is to evaluate the role of insulin resistance and high LH in causing elevated testosterone in obese girls.
  • We are recruiting obese (BMI-for-age percentile ≥ 95), 8 to 16 years of age, ≤ 2 years postmenarcheal girls.
  • This study requires 2 brief outpatient visits and one 20-hour (overnight) admission (4pm-noon).
  • Subjects will receive human insulin and glucose infusion (i.e., "insulin clamp" procedure), and will have insulin and glucose testing after ingesting a mixed meal.
  • Compensation is a $150 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information

Study #8:
SUPPRESSION OF DAYTIME AND NIGHTTIME LH FREQUENCY BY PROGESTERONE IN EARLY PUBERTY

(IRB-HSR# 13660)

  • In this study, we want to learn more about the hormone changes that occur during puberty.  In particular we are interested in the role of the hormone progesterone.
  • We are recruiting girls, 7 to 14 years of age.
  • This study requires 2 brief outpatient visits and one 22-hour (overnight) admission (9am-7am).
  • Subjects will take 3 small doses of progesterone or placebo during the admission.
  • Compensation is a $125 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information

Study #9:
GO GIRLS! FITNESS SUPPORT GROUP INTERVENTION EFFECTIVENESS STUDY                                

(IRB-HSR# 16132)

  • In this study, we want to know if participation in a fitness support group increases enjoyment of exercise, improves average amounts of daily exercise, and improves anthropometric and biochemical indices of metabolism and PCOS among girls.
  • We are recruiting girls, 7 to 21 years of age.
  • This study requires participation in the Go Girls! program as well as completion of a questionnaire at baseline, 3 months, and 6 months; optional blood work and/or anthropometrics at those three time points, as well.
  • Compensation is a $50 gift card.

Contact Anne Gabel at pcos@virginia.edu or (434) 243-6911 for more information