Research Publication

Research Publication

Bryce M. Paschal, Ph.D.
Associate Professor of Biochemistry and Molecular Genetics
Selected Publications:

Gioeli, D., and Paschal, B.M., (2011) Post-translational modification of the androgen receptor. Mol. Cell Endocrinol [Epub ahead of print].
Abstract

Kelly, J.B., Datta, S., Snow, C.J., Chatterjee, M., Ni, L., Spencer, A., Yang, C.S., Cubenas-Potts, C., Matunis, M.J., and Paschal, B.M., (2011) The defective nuclear lamina in Hitchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. Mol. Cell Biol. 31(16): 3378-95. PMCID: PMC3147792.
Abstract

Kelley, J.D., Talley, A.M., Spencer, A., Gioeli, D., and Paschal, B.M. (2010) Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol. 11: 63. PMCID: PMC2929220.
Abstract

Braddock, S.R., Ardinger, H.H., Yang, C.S., Paschal, B.M.and Hall, B.D. (2010) Petty syndrome and Fontaine-Farriaux syndrome: Delineation of a single syndrome. Am. J. Med. Genet A. 152A(7): 1718-23. PMID: 20583180.
Abstract

Ni, L., Yang, C.S., Gioeli, D., Frierson, H., Toft, D.O., and Paschal, B.M. (2010) FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. Mol. Cell Biol. 30(5): 1243-53. PMCID: PMC2820886.
Abstract

Galgano, M.T., Conaway, M., Spencer, A.M., Paschal, B.M., and Frierson, H.F. Jr. (2009) PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma. Hum Pathol. 40(10): 1434-40. PMCID: PMC2744839.
Abstract

Chen, S., Kesler, C.T., Paschal, B.M., and Balk, S.P (2009) Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. J. Biol Chem. 284(38): 25576-84. PMCID: PMC2757959.
Abstract

Kaikkonen, S., Jääskeläinen, T., Karvonen, U., Rytinki, M.M., Makkonen, H., Gioeli, D., Paschal, B.M., and Palvimo JJ. (2009) SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells. Mol Endocrin. PMID: 191162244. 

Shank, L.C., Kelley, J.B., Gioeli, D., Yang, C.Y., Spencer, A., Allison, L.A, and Paschal, B.M. (2008) Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro. J. Biol. Chem. 283: 10568-10580. PMID: 18270197

Kelley, J.B. and Paschal, B.M. (2007) Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP. Mol Biol. Cell. 18: 4365-4376. PMID: 17761537. 

Kesler, C. T., Gioeli, D., Conaway, MR, Weber, M., Paschal, B.M. (2007) Subcellular Localization Modulates AF-1 Domain Phosphorylation in the Androgen Receptor. Mol Endocrin. 21: 2071-2084. PMID: 17579212.

Sun K, Montana V, Chellappa K, Brelivet Y, Moras D, Maeda Y, Parpura V, Paschal B.M., Sladek FM. (2007) Phosphorylation of a conserved serine in the DNA binding domain of nuclear receptors alters intracellular localization. Mol Endocrinol. 21: 1297-1311. PMID: 17389749.

Yang CS, Xin HW, Kelley JB, Spencer A, Brautigan DL, Paschal B.M. (2007) Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions. Mol Cell Biol. 27(9):3390-404. PMID: 17325038.

Gioeli, D., Black,  B.E., Gordon, V., Spencer,  A., Kesler,  C.T., Eblen,  S.T., Paschal, B.M., Weber, M.J. (2006) Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization. Mol. Endocrinol. 20: 503-515.

Kehlenbach, R.H. and Paschal, B.M. (2006) Analysis of nuclear protein import and export in digitonin-permeabilized cells. In: Cell Biology: A Laboratory Handbook. J. Celis, ed. Academic Press, San Diego, pp. 267-275.

Lévesque, L., Matzat, M.H., Bor, Y., Jin, L., Berberoglu, S., Rekosh, D., Hammarskjöld, M.L., Paschal, B.M. (2006). Mutations in Tap Uncouple RNA Export Activity from Translocation through the Nuclear Pore Complex. Mol. Biol. Cell 17: 931-943.