Center for Cell Clearance: Leitinger Lab Publications

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Center for Cell Clearance: Leitinger Lab Publications

Leitinger Laboratory Selected Publications



· Cherepanova, OA et al.  Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration.  Circ Res.  104(5), 609-18  (2009)   PubMed Link



· Berliner, JA et al.  The role of oxidized phospholipids in atherosclerosis.  J Lipid Res.  ePub ahead of print.  (2008)   PubMed Link  

· Leitinger, N.  The role of phospholipid oxidation products in inflammatory and autoimmune diseases: evidence from animal models and in humans.  Subcell Biochem.  49,  325-50  (2008)   PubMed Link


· Kadl, A et al.  Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia.  Shock.  28(5),  582-8  (2007)   PubMed Link   

· Pidkovka, NA et al.  Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro.  Circ Res.  101(8),  792-801  (2007)   PubMed Link  

· Gleissner, CA et al.  Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis.  Hypertension.  50(2),  276-83  (2007)   PubMed Link

· Gruber, F et al.  Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells.  J Biol Chem.  282(23),  16934-41  (2007)   PubMed Link

 · Kronke, G et al.  Expression of heme oxygenase-1 in human vascular cells is regularly regulated by peroxisome proliferator-activated receptors.  Arterioscler Thromb Vasc Biol.  27(6),  1276-82  (2007)   PubMed Link  

· Huber, J et al.  Prevention of high-fat diet-induced adipose tissue remodelling in obese diabetic mice by n-3 polyunsaturated fatty acids.  Int J Obes (Lond).  31(6),  1004-13  (2007)   PubMed Link

· Knapp, S et al.  Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negaative sepsis in vivo.  J Immunol.  178(2),  993-1001  (2007)   PubMed Link  

· Holzer, G et al.  The dietary soy flavonoid genistein abrogates tissue factor induction in endothelial cells induced by the atherogenic oxidized phospholipid oxPAPC.  Thromb Res.  120(1),  71-9  (2007)   PubMed Link



· Bochkov, VN et al.  Oxidized phopholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions.  Circ Res.  99(8),  900-8  (2006)   PubMed Link

· Isakson, BE et al.  Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication.  Arterioscler Thromb Vasc Biol.  26(10),  2216-21  (2006)   PubMed Link

· Nonas, S et al.  Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury.  Am J Respir Crit Care Med.  173(10),  1130-8  (2006)   PubMed Link  

· Huber, J et al.  Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase.  J Lipid Res.  47(5),  1054-62  (2006)   PubMed Link

· Leitinger, N.  A rancid culprit in vascular inflammation acts on the prostaglandin receptor EP2.  Circ Res.  98(5),  587-9  (2006)   PubMed Link



· Kadl, A and Leitinger, N.  The role of endothelial cells in the resolution of acute inflammation.  Antioxid Redox Signal.  7(11-12),  1744-54  (2005)   PubMed Link

· Leonarduzzi, G et al.  Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells.  Free Radic Biol Med.  39(9),  1152-61  (2005)   PubMed Link

· Leitinger, N.  Oxidized phospholipids as triggers of inflammation in atherosclerosis.  Mol Nutr Food Res.  49(11),  1063-71  (2005)   PubMed Link

· Bluml, S et al.  Oxidized phospholipids negatively regulate dendritic cell maturation induced by TLRs and CD40.  J  Immunol.  175(1),  501-8  (2005)   PubMed Link

· Furnkranz, A et al.  Oxidized phospholipids trigger atherogenic inflammation in murine arteries.  Arterioscler Thromb Vasc Biol.  25(3),  633-8  (2005)   PubMed Link


· Birukov, KG et al.  Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.  Circ Res.  95(9),  892-901  (2004)   PubMed Link

· Kadl, A et al.  Apoptotic cells as sources for biologically active oxidized phospholipids.  Antioxid Redox Signal.  6(2),  311-20  (2004)   PubMed Link

· Furnkranz, A and Leitinger, N.  Regulation of inflammatory responses by oxidized phospholipids: structure-function relationships.  Curr Pharm Des.  10(8),  915-21  (2004)   PubMed Link

· Birukov, KG et al.  Signal transduction pathways activated in human pulmonary endothelial cells by OxPAPC, a bioactive component of oxidized lipoproteins.  Microvasc Res.  67(1),  18-28  (2004)   PubMed Link



· Kronke, G et al.  Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein.   J Biol Chem.  278(51),  51006-14  (2003)   PubMed Link

· Leitinger, N.  Oxidized phospholipids as modulators of inflammation in atherosclerosis.  Curr Opin Lipidol.  14(5),  421-30  (2003)   PubMed Link

· Bochkov, VN and Leitinger, N.  Anti-inflammatory properties of lipid oxidation products.  J Mol Med.  81(10),  613-26  (2003)   PubMed Link

· Leitinger, N.  Cholesteryl ester oxidation products in atherosclerosis.  Mol Aspects Med.  24(4-5),  239-50  (2003)   PubMed Link

· Huber, J et al.  The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.  Antioxid Redox Signal.  5(2),  163-9  (2003)   PubMed Link

· Srinivasan, S et al.  Glucose regulates monocyte adhesion through endothelial production of interleukin-8.  Circ Res.  92(4),  371-7  (2003)   PubMed Link


· Bochkov, VN et al.  Protective role of phospholipid oxidation products in endotoxin-induced tissue damage.  Nature.  419(6902),  77-81  (2002)   PubMed Link

· Hartwich, J et al.  Regulation of platelet adhesion by oxidized lipoproteins and oxidized phospholipids.  Platelets.  13(3),  141-51  (2002)   PubMed Link

· Huber, J et al.  Oxidized cholesteryl linoleates stimulate endothelial cells to bind monocytes via the extracellular signal-regulated kinase 1/2 pathway.  Arterioscler Thromb Vasc Biol.  22(4),  581-6  (2002)   PubMed Link

· Kadl, A et al.  Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS.  Vascul Pharmacol.  38(4),  219-27  (2002)   PubMed Link

· Huber, J et al.  Oxidized membrane vesicles and blebs from apoptotic cells containing biologically active oxidized phospholipids that induce monocye-endothelial interactions.  Arterioscler Thromb Vasc Biol.  22(1),  101-7  (2002)   PubMed Link

· Bochkov, VN et al.  Oxidized phospholipids stimulates tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT.  Blood.  99(1),  199-206  (2002)   PubMed Link


· Stulnig, TM et al.  Polyunsaturated eicosapentaenoic acid displaces proteins from membrane rafts by altering raft lipid composition.  J Biol Chem.  276(40),  37335-40  (2001)   PubMed Link

·Yeh, M et al.  Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids.  Arterioscler Thromb Vasc Biol.  21(10),  1585-91  (2001)   PubMed Link

· Leitinger, N et al. The isoprostane 8-iso-PGF(2alpha) stimulates endothelial cells to bind monocytes: differences from thromboxane-mediated endothelial activation.  FASEB J.  15(7),  1254-6  (2001)   PubMed Link

· Berliner, JA et al.  Evidence for a role of phospholipid oxidation products in atherogenesis.  Trends Cardiovasc Med.  11(3-4),  142-7  (2001)   PubMed Link



· Subbanagounder, G et al.  Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position.  Arterioscler Thrombin Vasc Biol.  20(10),  2248-54  (2000)   PubMed Link


PubMed complete list of publications