Tissue microarray technology places up to a thousand discs of tissue on a single glass slide, which can then be assayed by histologic staining, immunohistochemistry and/or in situ hybridization.
For further description of TMA technology, please go here.
The BTRF can create custom TMAs for investigators, using formalin-fixed paraffin-embedded tissue either provided by the investigator, or obtained from the archives of the UVA Pathology Department.
The BTRF has also created a TMA set that surveys 159 common carcinomas. For a description, please go here.
The BTRF collaborates with NCI-sponsored consortia groups to create other TMAs that may be obtained by UVA investigators. For a description of of TMAs, fees and application forms, please follow the links below.
Cooperative Human Tissue Network (TMAs of normal tissues, brain tissues, colon cancer, ovarian cancer, breast cancer)
Cooperative Breast Cancer Tissue Resource (designed to test biomarkers for prognostic ability)
NCI Cancer Diagnosis Program Colon Cancer TMA (designed to test biomarkers for prognostic significance)
NCI Cancer Diagnosis Program Melanoma Progression TMA (designed to test different biological stages of melanoma progression)
Other TMA sites of interest:
Prostate Cancer Biorepository Network (several different TMAs with prostate cancer specimens available)
Children's Oncology Group and Gynecologic Oncology Group (several different TMAs of pediatric and gynecologic cancers available by inquiry at this contact site)