Equipment for Molecular Imaging

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Equipment for Molecular Imaging


7 Tesla Bruker/Siemens ClinScan small animal MRI

  • 8 receiver channels for phased array imaging
  • maximum strength 600 mT m-1
  • maximum rise rate 6000 T m-1 s-1
  • software from human MRI ports to this instrument
  • detailed description from Bruker

This instrument was the first installation of it type in the US
In MR4, room 1184
picture of ClinScanMRI

 

4.7 Tesla Varian 200/400 MRI small animal imager with Varian Direct Drive imaging console

  • full microimaging capabilities
  • accessible bore of magnet is 16 cm
  • 400 mT.m-1 maximum strength
  • 3200 mT.m-1.s-1 rise rate
  • mainly used for cardiovascular and cancer research.
  • upgraded since installation
In Snyder Building, Fontaine Research Park.
picture of Varian 4.7 Tesla MRI

Caliper IVIS Spectrum bioluminescence and fluorescence scanner

Common uses:

  • firefly and bacterial luciferase
  • Green Fluorescent Protein
  • red and near-infrared fluorescent proteins
  • other luminescent and fluorescent labels


It has 10 excitation filters (top or bottom illumination) and 18 emission filters.
More details from Caliper Life Sciences.

Tomographic fluorescent and luminescence images from the Spectrum scanner can be merged with MRI or CT scans. IVIS Spectrum in MR4 Vivarium.

picture of Xenogen fluorescence and bioluminescence imager

Siemens Medical Solutions Focus 120  Micro Positron Emission Tomography scanner

  • optimized for imaging rodents
  • 1.25mm spatial resolution
  • ability to cardiac and respiratory gate
  • full software analysis package
  • detailed description from Siemens
In Snyder Building, Fontaine Research Park.
picture of MicroPET scanner

SA Instruments model 1025 and 1025L physiological monitoring

Animals’ heart rate and breathing are monitored using SA Instruments model 1025 for MRI and a model 1025L for PET and SPECT hardware/software systems for monitoring and gating system.

Chemistry laboratory

The  radiochemistry lab adjacent to the cyclotron has underground conduits to deliver radioisotopes to the lab. There are six Von Gahlen minicells that are populated with the following:

  1. Eckert & Ziegler (E&Z) Modular Lab [11C] for the production of methyl iodide or methyl triflate
  2. E&Z Modular-Lab PharmTracer system for the production of a variety of radiolabeled biomarkers using 11C methyl iodide/triflate or 18F-;
  3. Siemens Explora GN for general Nucleophilic 18F- reactions;
  4. Siemens Explora CN which can be used for making 11C-HCN;
  5. Siemens Explora LC for preparative liquid chromatography for purification of products
  6. a dose calibrator for measurement of radioactivity of starting material and final products.
Radiochemistry

Cyclotron laboratory

A Siemens Eclipse™ HP 11 MeV Cyclotron is in the Life Sciences Annex at Fontaine Research Park. This laboratory produces  curies of short lived PET isotopes, 18F 11C, 13N, and 15O, longer lived PET isotopes 64Cu, 76Br, 124I, gamma isotopes 67Ga, 123I, and 111In and 165Er. It is operated in partnership with Siemens/PETNET. Cyclotron

 

Vivarium facilities

Both Snyder Building and MR4 have vivarium facilities.