7 Tesla Bruker/Siemens ClinScan small animal MRI

8 receiver channels for phased array imaging maximum strength 600 mT m-1 maximum rise rate 6000 T m-1 s-1 software from human MRI ports to this instrument detailed description from Bruker This instrument was the first installation of it type in the US In MR4, room 1184

4.7 Tesla Varian 200/400 MRI small animal imager with Varian Direct Drive imaging console

full microimaging capabilities accessible bore of magnet is 16 cm 400 mT.m-1 maximum strength 3200 mT.m-1.s-1 rise rate mainly used for cardiovascular and cancer research. upgraded since installation In Snyder Building, Fontaine Research Park.

Caliper IVIS Spectrum bioluminescence and fluorescence scanner

Common uses:

firefly and bacterial luciferase Green Fluorescent Protein red and near-infrared fluorescent proteins other luminescent and fluorescent labels It has 10 excitation filters (top or bottom illumination) and 18 emission filters. More details from Caliper Life Sciences. Tomographic fluorescent and luminescence images from the Spectrum scanner can be merged with MRI or CT scans. IVIS Spectrum in MR4 Vivarium.

Siemens Medical Solutions Focus 120  Micro Positron Emission Tomography scanner

optimized for imaging rodents 1.25mm spatial resolution ability to cardiac and respiratory gate full software analysis package detailed description from Siemens In Snyder Building, Fontaine Research Park.

SA Instruments model 1025 and 1025L physiological monitoring

Animals’ heart rate and breathing are monitored using SA Instruments model 1025 for MRI and a model 1025L for PET and SPECT hardware/software systems for monitoring and gating system.

Chemistry laboratory

The  radiochemistry lab adjacent to the cyclotron has underground conduits to deliver radioisotopes to the lab. There are six Von Gahlen minicells that are populated with the following:

1. Eckert & Ziegler (E&Z) Modular Lab [¹¹C] for the production of methyl iodide or methyl triflate
2. E&Z Modular-Lab PharmTracer system for the production of a variety of radiolabeled biomarkers using ¹¹C methyl iodide/triflate or ¹⁸F^-;
3. Siemens Explora GN for general Nucleophilic ¹⁸F^- reactions;
4. Siemens Explora CN which can be used for making ¹¹C-HCN;
5. Siemens Explora LC for preparative liquid chromatography for purification of products
6. a dose calibrator for measurement of radioactivity of starting material and final products.

Chemistry facilities for production of radiolabeled imaging compounds, MRI contrast agents, and fluorescently  labeled antibodies and peptides.

Cyclotron laboratory

A Siemens Eclipse™ HP 11 MeV Cyclotron is in the Life Sciences Annex at Fontaine Research Park. This laboratory produces  curies of short lived PET isotopes, ¹⁸F ¹¹C, ¹³N, and ¹⁵O, longer lived PET isotopes ⁶⁴Cu, ⁷⁶Br, ¹²⁴I, gamma isotopes ⁶⁷Ga, ¹²³I, and ¹¹¹In and ¹⁶⁵Er. It is operated in partnership with Siemens/PETNET.

Vivarium facilities

Both Snyder Building and MR4 have vivarium facilities.