Uganda Collaboration

Uganda Collaboration

University of Virginia collaboration: Mbarara University of Science and Technology

Mbarara is located about 290 kilometers (180 mi), by road, southwest of Kampala, Uganda's capital and largest city.  Mbarara is an important transport hub, lying west of Masaka on the road to Kabale, near Lake Mburo National Park.  Mbarara Regional Referral Hospital (MRRH) is the referral hospital for southwestern Uganda and serves as the teaching hospital for Mbarara University of Science and Technology (MUST) Faculty of Medicine. 

Dr. Christopher C. Moore has worked in Uganda since 2006 and is currently collaborating with the Department of Medicine at MRRH.  His research interests include sepsis pathophysiology with particular interest in the role of the innate immune system and sepsis pathophysiology, management, and outcomes of HIV infected patients in sub-Saharan Africa.  Recent collaborative projects between UVa and MUST led by Dr. Moore at MRRH have included outcomes studies of sepsis related to malaria, hypoglycemia, and malnutrition as well as diagnostic studies of bacterial and tuberculous meningitis.  There are opportunities for medical students and residents to participate in ongoing studies at MRRH.

Recent publications from Uganda:

   1.   Moore CC, Jacob ST, Pinkerton R, Meya DB, Mayanja-Kizza H, Reynolds SJ, Scheld WM. Point-of-care lactate testing predicts mortality of severe sepsis in a predominantly HIV type 1-infected patient population in Uganda. Clin.Infect.Dis. 2008 Jan 15;46(2):215-22

   2.   Jacob ST, Moore CC, Banura P, Pinkerton R, Meya D, Opendi P, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Scheld WM. Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population. PLoS.One. 2009;4(11):e7782. PMCID:PMC2771355

   3.   Moore CC, Jacob ST, Pinkerton R, Banura P, Meya DB, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Scheld WM. Treatment of severe sepsis with artemether-lumefantrine is associated with decreased mortality in Ugandan patients without malaria. Am.J.Trop.Med.Hyg. 2009 May;80(5):723-8

   4.   Clinical management of adult patients with complications of pandemic influenza A (H1N1) 2009 influenza: Emergency guidelines for the management of patients with severe respiratory distress and shock in district hospitals in limited-resource settings. Integrated Management of Adolescent and Adult Illness (IMAI), Global Influenza Programme (GIP), Global Alert and Response (GAR), World Health Organization. 2010 May;

   5.   Ssekitoleko R, Pinkerton R, Muhindo R, Bhagani S, Moore CC. Aggregate evaluable organ dysfunction predicts in-hospital mortality from sepsis in Uganda. Am.J.Trop.Med.Hyg. 2011 Oct;85(4):697-702. PMCID:PMC3183780

   6.   Ssekitoleko R, Jacob ST, Banura P, Pinkerton R, Meya DB, Reynolds SJ, Kenya-Mugisha N, Mayanja-Kizza H, Muhindo R, Bhagani S, et al. Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis. Crit Care Med. 2011 Oct;39(10):2271-6

   7.   Jacob ST, Banura P, Baeten JM, Moore CC, Meya D, Nakiyingi L, Burke R, Horton CL, Iga B, Wald A, et al. The impact of early monitored management on survival in hospitalized adult Ugandan patients with severe sepsis: a prospective intervention study*. Crit Care Med. 2012 Jul;40(7):2050-8. PMCID:PMC3378757

   8.   Majwala A, Burke R, Patterson W, Pinkerton R, Muzoora C, Wilson LA, Moore CC. Handheld point-of-care cerebrospinal fluid lactate testing predicts bacterial meningitis in Uganda. Am.J.Trop.Med.Hyg. In press, 2012.