Laboratory Publications

Laboratory Publications

Trainees (residents, postdocs or students) are underlined.

Sharma AK, Mulloy DP, Le LT, Laubach VE. NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol 306:L69-79, 2013. [Link]

Sharma AK, LaPar DJ, Stone ML, Zhao Y, Kron IL, Laubach VE. Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury. Amer J Transplant 13:2255-67, 2013.  [ Link]

Gillen JR, Zhao Y, Harris DA, Lapar DJ, Stone ML, Fernandez LG, Kron IL, Lau CL. Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model. Ann Thorac Surg 95(5):1768-75, 2013. [Link]

Fernandez LG, Sharma AK, LaPar DJ, Kron IL, Laubach VE. Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 145:1654-9, 2013. [Link]

Mulloy DP, Stone ML, Crosby IK, LaPar DJ, Sharma AK, Webb DV, Lau CL, Laubach VE, Kron IL. Ex vivo rehabilitation of non-heart-beating donor lungs in a preclinical porcine model: delayed perfusion results in superior lung function. J Thorac Cardiovasc Surg 144:1208-16, 2012. [Link]

Bhamidipati CM, Mehta GS, Lu G, Moehle CW, Barbery C, DiMusto PD, Laser A, Kron IL, Upchurch GR Jr, Ailawadi G. Development of a novel murine model of aortic aneurysms using peri-adventitial elastase. Surgery 152(2):238-46, 2012. [Link]

Lapar DJ, Sharma AK, Hajzus VA, Zhao Y, Lau CL, French BA, Kron IL, Laubach VE. Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling. Am J Respir Cell Mol Biol 46(3):299-305, 2011. [Link]

Emaminia A, LaPar DJ, Zhao Y, Steidle JF, Harris DA, Laubach VE, Linden J, Kron IL, Lau CL. Adenosine A(2A) agonist improves lung function during ex-vivo lung perfusion. Ann Thorac Surg 92:1840-6, 2011. [Link]

LaPar DJ, Laubach VE, Emaminia A, Crosby IK, Sharma AK, Sumner HM, Webb DV, Lau CL, and Kron IL. Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model. J Thorac Cardiovasc Surg 142(4):887-94, 2011. [Link]

Sharma AK, LaPar DJ, Zhao Y, Li L, Lau CL, Kron IL, Iwakura Y, Okusa MD, and Laubach VE. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Am J Respir Crit Care Med 183(11):1539-49, 2011. [Link]

Zhao Y, Sharma AK, LaPar DJ, Kron IL, Liu Y, Jones D, Laubach VE, and Lau CL.  Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation.  Am J Physiol Lung Cell Mol Physiol 300(5):L718-29, 2011. [Link]

Laubach VE, French BA, Okusa MD. Targeting of adenosine receptors in ischemia-reperfusion injury. Expert Opin Ther Targets. 15(1):103-18, 2011.  [Link]

Anvari F, Sharma AK, Fernandez LG, Hranjec T, Ravid K, Kron IL and Laubach VE. Tissue-derived pro-inflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140:871-7, 2010.  [Link]

Gazoni LM, Walters DM, Unger EB, Linden J, Kron IL, and Laubach VE. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 140(2):440-446, 2010. [Link]

Sharma AK, Laubach VE, Ramos SI, Zhao Y, Linden J, Kron IL, and Yang Z. Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 139(2):474-482, 2010. [Link]

Laubach VE and Kron IL. Pulmonary inflammation after lung transplantation. [Review] Surgery 146(1):1-4, 2009. [Link]

Lau CL, Zhao Y, Kron IL, Stoler MH, Laubach VE, Ailawadi G, and Linden J. The Role of Adenosine A2A Receptor Signaling in Bronchiolitis Obliterans. Ann Thorac Surg 88(4):1071-8, 2009. [Link]

Sharma AK, Linden J, Kron IL, and Laubach VE. Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. Respiratory Research 10:58, 2009. [Open Access]

Lau CL, Zhao Y, Kim J, Kron IL, Sharma A, Yang Z, Laubach VE, Linden J, Ailawadi G, and Pinsky DJ. Enhanced fibrinolysis protects against lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg 137(5):1241-1248, 2009.  [Link]

Yang Z, Sharma AK, Linden J, Kron IL, and Laubach VE. CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 137(3):695-702, 2009. [Link]

Yang Z, Laubach VE, French BA, and Kron IL. Acute hyperglycemia enhances oxidative stress and exacerbates myocardial infarction by activating NADPH oxidase during reperfusion. J Thorac Cardiovasc Surg 137(3):723-9, 2009. [Link]

Yang Z, Sharma AK, Marshall M, Kron IL, and Laubach VE. NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury. Am J Resp Cell Mol Biol 40(3):375-381, 2009.  [Link]

Lisle TC, Fernandez LG, Sharma AK, Bellizzi AM, Gazoni LM, Linden J, Laubach VE, and Kron IL. Inflammatory lung injury after cardiopulmonary bypass is ameliorated by adenosine A2A receptor activation. J Thorac Cardiovasc Surg 136(5):1280-7, 2008. [Link]

Ellman PI, Reece TB, Law MG, Gazoni LM, Singh R, Laubach VE, Tribble CG, and Kron IL. Adenosine A2A activation attenuates non-tranplantation lung reperfusion injury.  J Surg Res 149:3-8, 2008. [Link]

Gazoni LM, Laubach VE, Mulloy DP, Bellizzi A, Unger EB, Ellman PI, Lisle TC, Linden J, and Kron IL. Timing is everything. Additive protection against lung ischemia reperfusion injury by adenosine A2A receptor activation prior to procurement and during reperfusion. J Thorac Cardiovasc Surg 135:156-165, 2008. [Link]

Gazoni LM, Laubach VE, Mulloy DP, Bellizzi A, Unger EB, Linden J, Ellman PI, Lisle TC, Kron IL. Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion. J Thorac Cardiovasc Surg. 135(1):156-65, 2008.  [Link]

Fernandez LG, Mehta CK, Kron IL, and Laubach VE. Re-initiation of compensatory lung growth after subsequent lung resection. J Thorac Cardiovasc Surg 134:1300-1305, 2007.  [Link]

Sharma AK, Fernandez LG, Awad AS, Kron IL, and Laubach VE. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 293:105-113, 2007.  [Link]

Gazoni LM, Tribble CG, Zhao MQ, Unger EB, Farrar RA, Ellman PI, Fernandez LG, Laubach VE, and Kron IL. Pulmonary macrophage inhibition and inhaled nitric oxide attenuate lung ischemia reperfusion injury. Ann Thorac Surg 84:247-253, 2007. [Link]

Fernandez LG, Le Cras TD, Ruiz M, Glover DK, Kron IL, and Laubach VE. Differential vascular growth in postpneumonectomy compensatory lung growth. J Thorac Cardiovasc Surg 133:309-316, 2007. [Link]

Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, Kron IL, and Laubach VE. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 291:L1018-1026, 2006. [Link]

Singh RR, Laubach VE, Ellman PI, Reece TB, Unger E, Kron IL, and Tribble CG. Attenuation of lung reperfusion injury by modified ventilation and reperfusion techniques. J Heart Lung Transplant 25:1467-1473, 2006. [Link]

Reece TB, Okonkwo DO, Ellman PI, Maxey TS, Tache-Leon C, Warren PS, Laurent JJ, Linden J, Kron IL, Tribble CG, and Kern JA. Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping. Ann Thorac Surg 81:902-909, 2006. [Link]

Reece TB, Kron IL, Okonkwo DO, Laurent JJ, Tache-Leon C, Maxey TS, Ellman PI, Linden J, Tribble CG, and Kern JA. Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism. J Vasc Surg 44:392-397, 2006. [Link]

Maxey TS, Fernandez LG, Reece TB, Keeling WB, Kron IL, and Laubach VE. Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation. Ann Thorac Surg 81:1234-1238, 2006. [Link]

Reece TB, Laubach VE, Tribble CG, Maxey TS, Ellman PI, Warren PS, Schulman AM, Linden J, Kern JA, and Kron IL. Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury. Ann Thorac Surg 79:1189-1195, 2005. [Link]

Reece TB, Ellman PI, Maxey TS, Crosby IK, Warren PS, Chong TW, LeGallo RD, Linden J, Kern JA, Tribble CG, and Kron IL. Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation. J Thorac Cardiovasc Surg 129:1137-1143, 2005. [Link]

Patel MR, Laubach VE, Tribble CG, and Kron IL. Hyperinflation during lung preservation and increased reperfusion injury. J Surg Res 123:134-138, 2005. [Link]

Li D, Fernandez LG, Dodd-o J, Langer J, Wang D, and Laubach VE. Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy. Am J Respir Cell Mol Biol 32:185-191, 2005. [Link]

Le Cras TD, Fernandez LG, Pastura PA, and Laubach VE. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 98:1140-1148, 2005. [Link]

Ellman PI, Alvis JS, Tache-Leon C, Singh R, Reece TB, Kern JA, Tribble CG, and Kron IL. Hyperoxic ventilation exacerbates lung reperfusion injury. J Thorac Cardiovasc Surg 130:1440, 2005. [Link]

Reece TB, Okonkwo DO, Ellman PI, Warren PS, Smith RL, Hawkins AS, Linden J, Kron IL, Tribble CG, and Kern JA. The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation. J Thorac Cardiovasc Surg 128:925-932, 2004. [Link]

Reece TB, Davis JD, Okonkwo DO, Maxey TS, Ellman PI, Li X, Linden J, Tribble CG, Kron IL, and Kern JA. Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma. J Surg Res 121:130-134, 2004. [Link]

Maxey TS, Enelow RI, Gaston B, Kron IL, Laubach VE, and Doctor A. Tumor necrosis factor-alpha from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 127:541-547, 2004. [Link]

Long SM, Laubach VE, Tribble CG, Kaza AK, Fiser SM, Cassada DC, Kern JA, and Kron IL. Pyrrolidine dithiocarbamate reduces lung reperfusion injury. J Surg Res 112:12-18, 2003. [Link]