Animal Models
In our lab, Residents, Postdocs and students
utilize relevant animal models of lung injury, lung preservation,
transplantation, growth and injury. These models include:
- Lung transplant in pigs
- Ex
Vivo Lung Perfusion (EVLP)
- Mouse in vivo hilar clamp model of lung ischemia-reperfusion
- Isolated, buffer-perfused mouse lung system
-
Pneumonectomy (mice & rats) and lobectomy (rats and swine)
-
Cardiopulmonary bypass in rats
-
Trachea transplant in mice
|
Isolated mouse lungs. We use an isolated mouse lung system to
measure pulmonary function in mouse lungs. This is a buffer-perfused
system which is why the lungs are white in the movie below. |
Mouse left hilar clamp. We
utilize an in vivo mouse model of lung ischemia-reperfusion
injury via left hilar ligation.
|
|
Mouse pneumonectomy. Compensatory growth of the right lung after left pneumonectomy (right) in mice compared to normal left+right lungs (left). The time point shown is two weeks after pneumonectomy.
|
Mouse left hilar clamp. Shown here is a clamp placed around
the left hilum, which is comprised of the left pulmonary artery and
left bronchus. When clamped (or lilgated), the left lung is rendered
ischemic until the clamp (or ligation) is released. |
