NIH/NHLBI R01 HL119218.
Ex vivo perfusion in a lung box for rehabilitation of donor lungs.
Victor Laubach and Irving Kron (Multiple PI). 08/2013 – 07/2018.
This project studies the application of ex vivo lung perfusion with treatment with adenosine A2A receptor agonist in order to rehabilitate non-heart beating donor lungs for successful transplantation.
NIH/NHLBI R01 HL077301.
T Cell-Mediated Lung Ischemia-Reperfusion Injury.
Victor Laubach (PI). 07/2010 - 06/2014.
This project explores the role of T cells, the IL-17/IL-23 axis, and oxidative stress in lung ischemia-reperfusion injury.
Research Grant, Roche Organ Transplant Research Foundation,
Improving Lung Transplantation with Immediate Ex Vivo Perfusion
Irving Kron (PI). 04/01/2012 – 03/31/2014.
This project studies the appliation of ex vivo lung perfusion (EVLP) to non-heart beating donor lungs for the rehabilitation of these lungs for successful transplantation.
NIH/NHLBI T32 HL007849.
CardioThoracic Surgery Training Grant.
Irving Kron (PI). 07/2000 - 06/2015.
This grant provides training of surgery residents in laboratory research with a goal of developing quality academic surgeons. This program entails close collaboration between basic scientists and surgical faculty. Salary for two surgery residents per year (for two years each resident) are provided, for a total of 10 different trainees over a five year period.
NIH/NHLBI R01 HL092305.
Inflammation and oxidative stress in hyperglycemic exacerbation of infarct size.
Brent French and Irving Kron (MPI). 07/01/2009 - 06/30/2013.
This project studies whether acute hyperglycemia exacerbates myocardial infarct size by enhancing CD4+ T cell activation and RAGE stimulation and whether this will be abolished by adenosine A2A recptor activation.
NIH/NHLBI K08 HL094704. Adenosine 2A receptor signaling in
lung transplant injury and rejection.
Christine L. Lau (PI). 01/2009 - 12/2013.