Reduction of Femoral Artery Bleeding Post Cath. Using Percutaneous Application of Fibrin Sealant

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Reduction of Femoral Artery Bleeding Post Cath. Using Percutaneous Application of Fibrin Sealant

Reduction of Femoral Artery Bleeding Post
Catheterization Using Percutaneous Application of Fibrin Sealant

Suad Ismail, MD, Matthew J. Combs, PhD, Norman C. Goodman, BS, Sumeet S. Teotia, BA, Charles D. Teates, MD, Robert D. Abbott, PhD, Robert E. Fechner, MD, Stanton P. Nolan, MD, Eric R. Powers, MD, and William D. Spotnitz, MD

For complete paper:
Catheterization and Cardiovascular Diagnosis 1995;34:88-95

The number of cardiac catheterizations performed yearly is growing with correspondingly increasing amounts of morbidity, complications, and hospital costs. This study suggests that fibrin sealant instillation via an arterial sheath at the completion of femoral catheterization may improve hemostasis. Results using fibrin sealant in 12 unheparinized dogs documented significant reductions (McNemar's exact test) versus control for groin ecchymoses (1 versus 8, P = .008) and radiolabeled hematoma formation (0 versus 7, P = .016). Also swelling was less in the fibrin sealant treated groins when compared to control groins (1 versus 6, P = .125), but failed to reach statistical significance. Results in eight heparinized dogs (activated clotting time 374 +/- 22, mean +/- SEM) revealed a statistically significant reduction in signs of gross bleeding in the fibrin sealant-treated groins (1 versus 8, P = .016). This method may contribute to reduced morbidity, complications, and length of hospitalization. It may also allow for earlier patient mobilization after cardiac catheterization.

Key words: tissue adhesive; hemostasis; groin; percutaneous
Copyright © 1995 Wiley-Liss, Inc.