The Ubiquitin System and Human Cancer
Research in my laboratory is focused on understanding the role of
the ubiquitin system in the development and progression of human cancer
and its role in promoting cellular responses to current therapeutic
agents, such as ionizing radiation, and the development of resistance
to anti-cancer agents. We are particularly interested in investigating
the regulated process of protein ubiquitination and proteolysis of DNA
sensing and repair molecules. Currently, there are a handful of
examples where DNA repair proteins are regulated at the level of
ubiquitin-dependent proteolysis and current evidence suggest that many
others are yet to be identified specifically in post-repair recovery.
Thus, we hope this line of investigation will lead to the genetic and
biochemical characterization of novel pathways that can be potentially
exploited for therapeutic intervention.
Tarek Abbas, Ph.D.
Assistant Professor of Radiation Oncology
University of Virginia School of Medicine