John P. Mugler, III, PhD
Professor of Radiology and Medical Imaging; Biomedical
BS, University of Virginia, 1980
MS, Stanford University, 1981
PhD, Biomedical Engineering, University of Virginia, 1988
University of Virginia
Department of Radiology and Medical Imaging Research
Snyder Translational Research Building - Room 154
480 Ray C. Hunt Dr.
Charlottesville, VA 22903
My research focuses on the development and optimization of magnetic
resonance imaging (MRI) techniques, and draws on a variety of physics
and engineering principles with a strong emphasis on theoretical
modeling and simulation, and on practical implementation and
Currently, major projects include imaging and spectroscopy of the
human lung using hyperpolarized helium- and xenon-based methods, and
high-resolution 3-D imaging using conventional proton-based
methods. Hyperpolarized helium and xenon are new MR-based gaseous
contrast agents that are particularly well suited for imaging air
spaces such as those of the lung. Hyperpolarized-gas MR provides
high-resolution, detailed images of the lung that are far superior in
quality to those from any existing clinical imaging method, and offers
a variety of approaches for obtaining unique functional information
about the lung. Our research on high-resolution 3-D imaging aims
to increase spatial resolution, decrease acquisition time, and improve
image quality for methods applicable to routine clinical imaging
throughout the human body.
Hyperpolarized xenon-129 gas-exchange imaging of lung microstructure:
First case studies in subjects with obstructive lung disease.
Dregely I, Mugler JP 3rd, Ruset IC, Altes TA, Mata JF, Miller GW,
Ketel J. Ketel S, Distelbrink J, Hersman FW. Ruppert K.
J Magn Reson Imaging 2011; 33(5):1052-62.
magnetic resonance imaging of ventilation distribution and gas uptake
in the human lung using hyperpolarized xenon-129.
Mugler JP 3rd, Altes TA, Ruset IC, Dregely IM, Mata JF, Miller GW,
Ketel S, Ketel J, Hersman FW, Ruppert K.
Proc Natl Acad Sci U S A. 2010 Dec 14;50:21707-12.
resonance imaging of carotid atherosclerotic plaque in clinically
suspected acute transient ischemic attack and acute ischemic
Parmar JP, Rogers WJ, Mugler JP 3rd, Baskurt E, Altes TA, Nandalur KR,
Stukenborg GJ, Phillips CD, Hagspiel KD, Matsumoto AH, Dake MD, Kramer
Circulation. 2010 Nov 16;20:2031-8.
short-breath-hold technique for lung pO2 mapping with 3He
Miller GW, Mugler JP 3rd, Altes TA, Cai J, Mata JF, de Lange EE,
Tobias WA, Cates GD, Brookeman JR.
Magn Reson Med. 2010 Jan;1:127-36.
Reduction of B1 sensitivity in selective single-slab 3D
turbo spin echo imaging with very long echo trains.
Park J, Mugler JP 3rd, Hughes T.
Magn Reson Med 2009; 62:1060-66.