Jiang He, PhD
Associate Professor of Radiology and Medical Imaging
BS, Chemistry, Sichuan University, China, 1991
MS, Chemistry, Chinese Academy of Sciences, China, 1994
PhD, Chemistry, Peking University, China, 1997
Post-Doctorate, Catholic University of Louvain, Belgium, 2001
Post-Doctorate, University of Massachusetts Medical School, 2003
University of Virginia
Department of Radiology and Medical Imaging
Fontaine Research Park
480 Ray C. Hunt Dr., Rm 216
Charlottesville, VA 22903
Office Phone: 434-243-1011
Molecular imaging is an emerging research area aimed at imaging
specific molecular signatures - particularly those that are key targets
in disease processes. Unlike anatomical imaging, molecular imaging
displays the biochemical or physiological abnormalities underlying
disease, rather than the structural consequences of these
abnormalities. Potential clinical applications of molecular imaging in
diagnosis, patient stratification, and therapy response monitoring have
been widely recognized in recent years particularly with the explosive
advances of highly sensitive and quantitative PET imaging, which uses
imaging probes based on positron emitting isotopes.
The research themes in my lab are to develop novel radiotracers for
molecular imaging, and to design new biological nanoparticles for
combined imaging and therapy applications, in cancer, cardiovascular
and neurological disorders from animal studies to clinical use.
single chain antibody fragments that are rapidly internalizing
effectively target epithelioid and sarcomatoid mesotheliomas. Iyer
AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF,
Broaddus VC, Liu B, He J. Cancer Res. 2011 Apr
oligonucleotides for antisense imaging. Iyer AK, He J. Curr
Org Synth. 2011 Aug 1;8(4):604-614.
enhancement pretargeting: synthesis and testing of a 99mTc-labeled
bivalent MORF. He J, Wang Y, Dou S, Liu X, Zhang S, Liu G,
Hnatowich D. Mol Pharm. 2010 Aug 2;7(4):1118-24.
prostate cancer cells in vivo using a rapidly internalizing novel human
single-chain antibody fragment. He J, Wang Y, Feng J, Zhu X,
Lan X, Iyer AK, Zhang N. Seo Y, VanBrocklin HF, Liu B. J Nucl Med.
Identification of MCAM/CD146 as the target antigen of a human
monoclonal antibody that recognizes both epithelioid and sarcomatoid
types of mesothelioma. Bidlingmaier S, He J, Wang Y, An F,
Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Cancer Res. 2009
Development of an optimized activatable MMP-14 targeted SPECT imaging
probe. Watkins GA, Jones EF, Scott Shell M, VanBrocklin HF, Pan MH,
Hanrahan SM, Feng JJ, He J, Sounni NE, Dill KA, Contag CH,
Coussens LM, Franc BL. Bioorg Med Chem. 2009 Jan 15;17(2):653-9.