James R. Stone, M.D., Ph.D.
Assistant Professor of Radiology and Medical Imaging
M.D., Medicine, University of Virginia School of Medicine,
Charlottesville, VA, 2004
Ph.D., Anatomy and Neurobiology, Medical College of Virginia,
Richmond, Virginia, 2000
B.S., Biology, Virginia Commonwealth University, Richmond,
Clinical Fellow, Division of Interventional Radiology, Department of
Radiology, University of Virginia, Charlottesville, VA., 2010
Resident Physician, Interventional Radiology Clinical Pathway,
Department of Radiology, University of Virginia, Charlottesville, VA.,
Intern, Department of General Surgery, University of Virginia School
of Medicine, 2005
Research Fellow, Department of Anatomy and Neurobiology, Virginia
Commonwealth University School of Medicine, Richmond, VA., 2000
University of Virginia
Department of Radiology and Medical Imaging
480 Ray C Hunt Drive, Room 280
Charlottesville, VA 22903
Traumatic brain injury (TBI) sustained in modern military
TBI in the combat environment is a major cause of morbidity and
mortality in recent armed conflicts. Dr. Stone’s laboratory currently
explores questions related to improving the clinical diagnosis of this
disease process. Ongoing work includes the design and application of
novel molecular imaging probes for the detection of acute and chronic
effects of TBI. He is also involved with exploring novel ultrasound
based approaches for the detection of TBI in a far forward
In addition to exploring novel diagnostic for TBI, Dr. Stone is also
involved with ongoing work exploring the affect of repetitive low-level
blast exposure as an occupational hazard for humans who routinely work
in this type of environment. The goals of this work include determining
whether military service members in this environment are at risk for
development of mild TBI and helping to establish safe stand off limits
for low-level blast exposure.
Ahlers ST, Vasserman-Stokes E, Shaughness MC, Hall AA, Shear DA,
Chavko M, McCarron MR, Stone JR.
Assessment of the Effects of Acute and Repeated Exposure to Blast
Overpressure in Rodents: Toward a Greater Understanding of Blast and
the Potential Ramifications for Injury in Humans Exposed to Blast.
Frontiers in Neurotrauma. (2012) In Press.
Tustison NJ, Cook PA, Avants BB, Stone JR. Simulated
Diffusion-Weighted Imaging for the ITK Masses, Insight
Shafieian M, Darvish KK, Stone JR.
Changes to the Viscoelastic Properties of Brain Tissue after Traumatic
Axonal Injury. J. Biomechanics. 2009 18;42(13):2136-42.
Stone JR, Evans AJ, Angle JF, Arslan B, Turba UC, Matsumoto AH.
In vitro assessment of aortic stent-graft integrity following exposure
to Onyx liquid embolic agent. J Vasc Interv Radiol. 2009
Hagspiel KD, Stone JR, Leung DA.
Renal angioplasty and stent placement with distal protection:
preliminary experience with the FilterWire EX. J Vasc Interv
Radiol. (2005) 16(1);125-31.
Stone JR, Okonkwo DO, Dialo AO, Rubin DG, Mutlu LK, Povlishock
JT, Helm GA.
Impaired axonal transport and altered axolemmal permeability occur in
distinct populations of damaged axons following traumatic brain
injury. Exp Neuro (2004) 190: 59-69.
Mills, J.D., Stone, J.R., Rubin, D.G., Melon, D.E., Okonkwo,
D.O., Periasamy, A.P., Helm, G.A.
A confocal laser scanner and multi-photon fluorescent resonance energy
transfer (FRET) methodology for illuminating protein interactions in
tissue sections. J. Biomedical Optics (2003) July;8(3).
Stone, J.R., Okonkwo, D.O., Singleton, R.H., Mutlu, L., Helm,
G.A., and Povlishock, J.T.
Caspase-3 mediated cleavage of the amyloid precursor protein and
formation of the amyloid beta peptide in traumatic axonal injury.
J. Neurotrauma (2002) May;19(5):601-14