Kai Ruppert, Ph.D.
Assistant Professor of Radiology and Medical Imaging
M.S., Physics, Technische Universität Braunschweig,
Braunschweig, Germany, 1994
Ph.D., Bio-Physics, University of Virginia, 1999
University of Virginia
Department of Radiology and Medical Imaging Research
Fontaine Research Park
480 Ray C. Hunt Dr.
Charlottesville, VA 22903
Office Phone: 1 434-243-1770
My research interests are the development of hyperpolarized media
MRI techniques. I have focused in particular on hyperpolarized helium-3
MR imaging as well as the development of new MR spectroscopy and
imaging pulse sequences for hyperpolarized xenon-129 MRI. I investigate
the use of these tools to measure or detect changes in various
physiological lung parameters such as the surface-to-volume ratio, the
effective xenon diffusion constant in lung tissue as well as the
alveolar wall thickness and alveolar diameter in healthy and diseased
lungs. Current research projects include:
- Multiple exchange time Xenon-polarization Transfer Contrast (MXTC)
- Hyperpolarized helium-3 ventilation imaging in asthmatic
- Quantification of pulmonary xenon uptake and exchange
xenon polarization transfer contrast (MXTC) MRI: initial results in
animals and healthy volunteers. Dregely I, Ruset IC, Mata JF, Ketel
J, Ketel S, Distelbrink J, Altes TA, Mugler JP 3rd, Wilson Miller G,
William Hersman F, Ruppert K. Magn Reson Med. 2012
Xenon-129 gas-exchange imaging of lung microstructure: first case
studies in subjects with obstructive lung disease. Dregely I,
Mugler JP 3rd, Ruset IC, Altes TA, Mata JF, Miller GW, Ketel J, Ketel
S, Distelbrink J, Hersman FW, Ruppert K. J Magn Reson Imaging.
Assessment of in vitro vs. in vivo lung structure using hyperpolarized
helium-3 diffusion magnetic resonance imaging. Mata JF, Altes TA,
Ruppert K, Hagspiel KD, Miller GW, Brookeman JR, Mugler JP.
Magn Reson Imaging. 2009; 27:845-851.
Assessment of the lung microstructure in patients with asthma using
hyperpolarized (3)He diffusion MRI at two time scales: Comparison with
healthy subjects and patients with COPD. J Wang C, Altes TA, Mugler
III JP, Miller GW, Ruppert K, Mata JF, Cates Jr GD, Borish L, de
Lange EE. Magn Reson Imaging 2008 Jun 25; 28(1):80-88.
and diffusion tensor imaging for pediatric musculoskeletal
disorders. MacKenzie JD, Gonzalez L, Hernandez A, Ruppert K,
Jaramillo D. Pediatric Radiology 2007; 37(8):781-788.
Sensitivity Improvements through Parameter Optimizations.
Ruppert K, Mata JF, Wang H-TJ, Tobias WA, Cates GD, Brookeman
JR, Hagspiel KD, Mugler III JP. XTC MRI:
Magnetic Resonance in Medicine 2007; 57(6):1099-1109.
Evaluation of Emphysema Severity and Progression in a Rabbit Model: A
Comparison of Diffusion Hyperpolarized He-3 and Xe-129 MRI with Lung
Morphometry. Mata JF, Altes TA, Cai J, Ruppert K, Mitzner W,
Hagspiel KD, Salerno M, Brookeman JR, de Lange EE, Mugler JP. Journal
of Applied Physiology 2007; 102(3):1273-1280.