James Brookeman

James Brookeman

  • Brookeman

James Brookeman, PhD

Professor of Radiology and Medical Imaging; Biomedical Engineering

BSc, (Honors), Physics, St. Andrews University, Scotland, 1964
PhD, Physics, St. Andrews University, Scotland, 1968

University of Virginia
Department of Radiology and Medical Imaging Research
Fontaine Research Park
480 Ray C. Hunt Dr.
Charlottesville, VA  22903


Research Interests

Our research seeks to improve methods of both two-dimensional and three-dimensional magnetic resonance image acquisition for diagnosis and for the planning and development of specialized radiofrequency coils for improved imaging used in surgery.

Since 1996 we have pursued research in Hyperpolarized Noble Gas MR as well, employing laser-polarized Helium-3 and Xenon-129 to study lung ventilation, virtual colonoscopy, and tissue perfusion. We are currently investigating a series of asthma and COPD subjects to evaluate the clinical potential of this new lung imaging technique.


A short-breath-hold technique for lung pO2 mapping with 3He MRI. Miller GW, Mugler JP 3rd, Altes TA, Cai J, Mata JF, de Lange EE, Tobias WA, Cates GD, Brookeman JR. Magn Reson Med. 2010 Jan;63(1):127-36.

Assessment of in vitro vs. in vivo lung structure using hyperpolarized helium-3 diffusion magnetic resonance imaging. Mata JF, Altes TA, Ruppert K, Hagspiel KD, Miller GW, Brookeman JR, Mugler JP 3rd. Magn Reson Imaging. 2009 Jul;27(6):845-51. Epub 2009 Mar 9.

Helium-3 diffusion MR imaging of the human lung over multiple time scales. Mugler JP 3rd, Wang C, Miller GW, Cates GD Jr, Mata JF, Brookeman JR, de Lange EE, Altes TA. Acad Radiol. 2008 Jun;15(6):693-701.

Extending the range of diffusion times for regional measurement of the 3He ADC in human lungs. Wang C, Miller GW, Altes TA, de Lange EE, Cates GD Jr, Mata JF, Brookeman JR, Mugler JP 3rd. Magn Reson Med. 2008 Mar;59(3):673-8.

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