Medical Imaging Trials
PI: Abdullah Al-Osaimi, M.D.
MR Spectroscopy of the Liver in Correlation with Histology in NASH patients
PI: Talissa Altes, M.D.
A Comparison of Helium versus Xenon in Hyperpolarized Noble Gas Magnetic Resonance Imaging of Cystic Fibrosis Lung Pathology
A Phase 2, Single-Blind, Placebo-Controlled Study to Evaluate the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects with Cystic Fibrosis, the G551D Mutation, and FEV1 >=40% Predicted
Hyperpolarized noble-gas enhanced imaging of b2-agonist pharmacodynamics and pharmacokinetics in mild to moderate asthma
Hyperpolarized Xenon-129 MR imaging of the Lung
MRI as a Means to Measure Lung Function in Cystic Fibrosis: Non-Invasive Imaging in Neonates and Young Children
MR Perfusion imaging in Healthy Normal Subjects and in Subjects with Lung Disease
Regulatory Advancement of HXe as a Diagnostic MRI Contrast Agent: A Phase 2 Clinical Trial
Analysis of Body Fat using MRI/MRS in Healthy Children and in Cystic Fibrosis
CNS Effects of Inhaled gas
PI: John Angle, M.D.
Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis (The ATTRACT Trial)
Clinical Study to Evaluate the Safety and Effectiveness of the Zenith Branch Endovascular Graft-Iliac Bifurcation with the Zenith Connection Endovascular Covered Stent
CORAL Clinical Study
Evaluation of the Zilver PTX Vascular Stent in the Above-the-Knee Femoropopliteal Artery (Protocol 04-518)
OSPREY: Occlusive/Stenotic Peripheral artery Revascularization study: A Multi-center clinical trial of the Misago Self-Expanding Stent System for Superficial Femoral Artery
Renal Denervation in Patients with Uncontrolled Hypertension: SYMPLICITY HTN-3
PI: Eduard de Lange M.D.
Hyperpolarized Helium-3 MR Lung Imaging Findings in Asthmatics
PI: Avery Evans, M.D.
Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) - Protocol 99-705
The primary goal of CREST is to assess if the efficacy of CAS differs from that of CEA over a multi-year time horizon.
Hydrocoil Cerebral Aneurysm Treatment Trial (H-CAT)
Purpose: To compare clinical and angiographic outcomes in patients receiving Hydrocoil aneurysm treatment versus patients receiving Cerecyte aneurysm treatment.
MR and Recanalization of Stroke Clots Using Embolectomy (MR-RESCUE)
The MR RESCUE trial is a multicenter, randomized, controlled, blinded outcome evaluator, phase IIB trial employing a clot retrieval device in patients experiencing acute ischemic stroke due to a proximal large vessel anterior circulation occlusion 0-8 hours from symptom onset. Successful conduct of the trial will evaluate whether use of multimodal imaging is a rational and appropriate selection criterion for mechanical recanalization therapy for acute ischemic stroke.
PAC Large & Giant Aneurysms Registry: Presidio and Cerecyte Coils Evaluation in Large and Giant Aneurysms
The objective of this registry is to assess the angiographic outcomes and morbidity-mortality of endovascular treatment of large and giant aneurysms using Cerecyte coils including a minimum of one Presidio coil, as a framing coil.
Patients Prone to Recurrence after Endovascular Treatment: a randomized trial comparing platinum and hydrogel-coated coils (PRET)
The PRET trial is a large multicentre prospective randomized trial of endovascular management of aneurysms prone to recurrence after endovascular treatment comparing hydrogel-coated and platinum standard coil. It aims to recruit 250 patients with large aneurysms (≥ 10mm) and 250 patients with recurrent aneurysms in 23-40 centres in two years. The clinical impact will be of major significance if substantial differences are found in the outcome according to a randomized procedure.
PSAS - Packing Density in Smaller Aneurysms: How Significant? (PM2009-01)
Stenting and angioplasty with protection in patients at high-risk for endarterectomy (protocol no. P06-3603) (SAPPHIRE)
This study is a multicenter, prospective, observational study to assess the outcomes of stenting with emboli protection in the treatment of obstructive carotid artery disease.
PI: Spencer Gay, M.D.
A Phase 4 randomized, double blind study comparing patient comfort and safety between Iodixanol 320 mg I/ml and Iopamidol 370 mg I/ml in patients undergoing contrast enhanced tomographic (CECT) imaging of the abdomen/pelvis (GE-012-097)
PI: Jennifer Harvey, M.D.
A Multicenter, Controlled Clinical Trial to Evaluate the Hologic Tomosynthesis Mammography System (Protocol 09-03)
Building a better model: a comprehensive breast cancer risk model incorporating breast density to stratify risk and apply resources
Genes that Account for Variation in Mammographic Breast Density
PI: Mary Jensen, M.D.
Gaining Efficacy Long-Term Hydrosoft and Emerging New Embolic Coil (Gel-the-nec)
PI: Christopher M. Kramer, M.D.
2R01 HL075792-08A1 (NHLBI) Comprehensive magnetic resonance in PAD
Aim 1 is to optimize contrast enhanced and non-contrast MRI techniques to fully quantify blood flow in the calf muscle in patients with PAD. The second aim is to compare stressors (exercise vs. cuff occlusion) in the measurement of peak blood flow. Aim 3 is to use the optimized techniques in Aims 1 and 2 to test the benefit of home exercise therapy on peak calf muscle blood flow and energetics in patients with PAD.
11-GRANT-7370022 (AHA) Contrast-enhanced MRI with T1 mapping to identify early chemotherapeutic cardiotoxicity
The goal is to examine whether post-gadolinium T1 mapping can be a marker of myocardial injury prior to decline in left ventricular function in the setting of anthracycline chemotherapy.
UVA Health System Clinical Research Support Grant Identification of Microvascular Disease in Patients with Angina
The aim is to demonstrate the presence and prognostic value of abnormal coronary flow reserve in women, diabetics, and patients with the metabolic syndrome who have chest pain but no obstructive coronary artery disease.
ACZ885M2201 Novartis Pharmaceuticals Corp. A multicenter, randomized, double-blind, placebo-controlled study of the safety, tolerability, and effects on arterial structure and function of ACZ885 in patients with intermittent claudication.
The goals are to develop the imaging guidance for the overall study, provide an MRI quality review and image analysis of all MR scans performed under this study at all sites, and to perform the MR scans for patients recruited at a local clinical trial site.
1UH3 TR000959-01 (NHLBI) Reuse of ZD4054 (zibotentan):patients with symptomatic PAD
The study will seek to confirm the safety and tolerability of 10mg of zibotentan (ZD4054), an orally active, endothelin receptor A (ETA) antagonist in patients with intermittent claudication (Rutherford II or III) and, in parallel, establish the capacity of ZD4054 to change calf muscle perfusion, as assessed by contrast-enhanced magnetic resonance imaging, functional treadmill performance, and quality of life indicators.
PI: Kenneth Liu, M.D.
ACE: Aneurysm Coiling Efficiency Study of the Penumbra Coil 400 System
PI: Alan Matsumoto, M.D.
A Phase IV Clinical Study to Evaluate the Safety of MR-Guided Focused Ultrasound Treatment of Uterine Fibroids With Enhanced Sonication Techniques
Evaluation of the Clinical Performance of the Valiant Thoracic Stent Graft with the Captivia Delivery System for the Endovascular Treatment of Blunt Thoracic Aortic Injuries (RESCUE)
Evaluation of the GORE Conformable TAG® Thoracic Endoprosthesis for Treatment of Acute Complicated Type B Aortic Dissection: TAG 08-01
Evaluation of the GORE TAG® Thoracic Endoprosthesis 45 mm for the Primary Treatment of Aneurysms of the Descending Thoracic Aorta (Protocol Number: TAG 06-02)
Evaluation of the GORE TAG® Thoracic Endoprosthesis for the Treatment of Complex Pathology of the Descending Thoracic Aorta (TAG 04-01)
Patient Long-term Follow-Up to Collect Data Following MR-Guided Focused Ultrasound Treatment of Uterine Fibroids with Enhanced Sonication Techniques
Prospective, Multicenter, Randomized Controlled Trial of Endovascular Aneurysm Repair Using a Bilateral Percutaneous Approach (PEVAR) vs. Standard Approach (SEVAR) Using the IntuiTrak Endovascular AAA Delivery System and the Prostar XL or Perclose ProGlide Suture-Mediated Closure System
Zenith® TX2™ THORACIC TAA Endovascular Graft Clinical Trial (Protocol No. 03-536)
Zenith® TX2™ THORACIC TAA Endovascular Graft Post-Approval Study
PI: Patrick Norton, M.D.
Assessment of Left Atrial Function by MRI Following Atrial Fibrillation Ablation
PI: James Stone, M.D.
VenaTech™ Convertible™ Vena Cava Filter U.S. Multi-Center Clinical Trial
PI: Elias William (Jeff), M.D.
Database of patients interested in clinical trials involving Focused Ultrasound Surgery for Movement Disorders
PI: Mark Williams, Ph.D.
Novel Systems for Molecular Breast Imaging
Pilot Study of Dual Modality Surgical Guidance for Non-Palpable Breast Lesions
PI: Max Wintermark, M.D.
Systemic Assessment of ASIR Algorithm for Optimal Neuroimaging in terms of Image Quality and Radiation Dose
The goal of this project is to test systematically the use of the ASIR algorithm for all neuroradiology CT protocols, including perfusion-CT, and determine whether, using ASIR, the radiation dose associated with these protocols can be reduced while the image quality is maintained.