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Medical Imaging Trials

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PI: Abdullah Al-Osaimi, M.D.

MR Spectroscopy of the Liver in Correlation with Histology in NASH patients

PI: Talissa Altes, M.D.

A Comparison of Helium versus Xenon in Hyperpolarized Noble Gas Magnetic Resonance Imaging of Cystic Fibrosis Lung Pathology

A Phase 2, Single-Blind, Placebo-Controlled Study to Evaluate the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects with Cystic Fibrosis, the G551D Mutation, and FEV1 >=40% Predicted

Hyperpolarized noble-gas enhanced imaging of b2-agonist pharmacodynamics and pharmacokinetics in mild to moderate asthma

UVa Health System, Radiology Research seeks adults ages 18 and older with asthma for a research study

Hyperpolarized Xenon-129 MR imaging of the Lung

MRI as a Means to Measure Lung Function in Cystic Fibrosis: Non-Invasive Imaging in Neonates and Young Children

Healthy Children and children with cystic fibrosis ages 10 months and older needed for research study

MR Perfusion imaging in Healthy Normal Subjects and in Subjects with Lung Disease

Women and Men ages 18 and older needed for MRI study

Regulatory Advancement of HXe as a Diagnostic MRI Contrast Agent: A Phase 2 Clinical Trial

Adults with healthy lungs and those with lung disease OR smokers needed for a research study

Analysis of Body Fat using MRI/MRS in Healthy Children and in Cystic Fibrosis

CNS Effects of Inhaled gas

PI: John Angle, M.D.

Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis (The ATTRACT Trial)

Department Of Radiology Seeks Volunteers Ages 16-70 With Acute Venous Thrombosis For Research Study

Clinical Study to Evaluate the Safety and Effectiveness of the Zenith Branch Endovascular Graft-Iliac Bifurcation with the Zenith Connection Endovascular Covered Stent

CORAL Clinical Study

Evaluation of the Zilver PTX Vascular Stent in the Above-the-Knee Femoropopliteal Artery (Protocol 04-518)

OSPREY: Occlusive/Stenotic Peripheral artery Revascularization study: A Multi-center clinical trial of the Misago Self-Expanding Stent System for Superficial Femoral Artery

Renal Denervation in Patients with Uncontrolled Hypertension: SYMPLICITY HTN-3

PI: Jessica Connelly

Epigenetic modulation of social brain function (JJC001)

Seeking healthy volunteers ages 18-30 with no history of brain injury or disease

PI: Thomas Jason Druzgal

Temporal Stability of MRI Neuroimaging

Healthy adults needed for a brain MRI study

Postseason Timeline of Physiologic Changes from High Impact Sports

Research study for healthy high school or college football players

PI: Eduard de Lange M.D.

Hyperpolarized Helium-3 MR Lung Imaging Findings in Asthmatics

PI: Avery Evans, M.D.

Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) - Protocol 99-705

Hydrocoil Cerebral Aneurysm Treatment Trial (H-CAT)

MR and Recanalization of Stroke Clots Using Embolectomy (MR-RESCUE)

The MR RESCUE trial is a multicenter, randomized, controlled, blinded outcome evaluator, phase IIB trial employing a clot retrieval device in patients experiencing acute ischemic stroke due to a proximal large vessel anterior circulation occlusion 0-8 hours from symptom onset. Successful conduct of the trial will evaluate whether use of multimodal imaging is a rational and appropriate selection criterion for mechanical recanalization therapy for acute ischemic stroke.

PAC Large & Giant Aneurysms Registry: Presidio and Cerecyte Coils Evaluation in Large and Giant Aneurysms

The objective of this registry is to assess the angiographic outcomes and morbidity-mortality of endovascular treatment of large and giant aneurysms using Cerecyte coils including a minimum of one Presidio coil, as a framing coil.

Patients Prone to Recurrence after Endovascular Treatment: a randomized trial comparing platinum and hydrogel-coated coils (PRET)

The PRET trial is a large multicentre prospective randomized trial of endovascular management of aneurysms prone to recurrence after endovascular treatment comparing hydrogel-coated and platinum standard coil. It aims to recruit 250 patients with large aneurysms (≥ 10mm) and 250 patients with recurrent aneurysms in 23-40 centres in two years. The clinical impact will be of major significance if substantial differences are found in the outcome according to a randomized procedure.

PSAS - Packing Density in Smaller Aneurysms: How Significant? (PM2009-01)

Stenting and angioplasty with protection in patients at high-risk for endarterectomy (protocol no. P06-3603) (SAPPHIRE)

This study is a multicenter, prospective, observational study to assess the outcomes of stenting with emboli protection in the treatment of obstructive carotid artery disease.

PI: Spencer Gay, M.D.

A Phase 4 randomized, double blind study comparing patient comfort and safety between Iodixanol 320 mg I/ml and Iopamidol 370 mg I/ml in patients undergoing contrast enhanced tomographic (CECT) imaging of the abdomen/pelvis (GE-012-097)

PI: Jennifer Harvey, M.D.

A Multicenter, Controlled Clinical Trial to Evaluate the Hologic Tomosynthesis Mammography System (Protocol 09-03)

Building a better model: a comprehensive breast cancer risk model incorporating breast density to stratify risk and apply resources

UVA Mammography Project: Shaping the Future of Breast Cancer Screening

Genes that Account for Variation in Mammographic Breast Density

PI: Mary Jensen, M.D.

Gaining Efficacy Long-Term Hydrosoft and Emerging New Embolic Coil (Gel-the-nec)

PI: Christopher M. Kramer, M.D.

2R01 HL075792-08A1 (NHLBI) Comprehensive magnetic resonance in PAD

Aim 1 is to optimize contrast enhanced and non-contrast MRI techniques to fully quantify blood flow in the calf muscle in patients with PAD. The second aim is to compare stressors (exercise vs. cuff occlusion) in the measurement of peak blood flow. Aim 3 is to use the optimized techniques in Aims 1 and 2 to test the benefit of home exercise therapy on peak calf muscle blood flow and energetics in patients with PAD.

11-GRANT-7370022 (AHA) Contrast-enhanced MRI with T1 mapping to identify early chemotherapeutic cardiotoxicity

The goal is to examine whether post-gadolinium T1 mapping can be a marker of myocardial injury prior to decline in left ventricular function in the setting of anthracycline chemotherapy.

UVA Health System Clinical Research Support Grant    Identification of Microvascular Disease in Patients with Angina

The aim is to demonstrate the presence and prognostic value of abnormal coronary flow reserve in women, diabetics, and patients with the metabolic syndrome who have chest pain but no obstructive coronary artery disease.


ACZ885M2201  Novartis Pharmaceuticals Corp. A multicenter, randomized, double-blind, placebo-controlled study of the safety, tolerability, and effects on arterial structure and function of ACZ885 in patients with intermittent claudication.

The goals are to develop the imaging guidance for the overall study, provide an MRI quality review and image analysis of all MR scans performed under this study at all sites, and to perform the MR scans for patients recruited at a local clinical trial site.



1UH3 TR000959-01 (NHLBI)  Reuse of ZD4054 (zibotentan):patients with symptomatic PAD

The study will seek to confirm the safety and tolerability of 10mg of zibotentan (ZD4054), an orally active, endothelin receptor A (ETA) antagonist  in patients with intermittent claudication (Rutherford II or III) and, in parallel, establish the capacity of ZD4054 to change calf muscle perfusion, as assessed by contrast-enhanced magnetic resonance imaging, functional treadmill performance, and quality of life indicators.

PI: Kenneth Liu, M.D.

ACE: Aneurysm Coiling Efficiency Study of the Penumbra Coil 400 System

PI: Alan Matsumoto, M.D.

A Phase IV Clinical Study to Evaluate the Safety of MR-Guided Focused Ultrasound Treatment of Uterine Fibroids With Enhanced Sonication Techniques


Evaluation of the Clinical Performance of the Valiant Thoracic Stent Graft with the Captivia Delivery System for the Endovascular Treatment of Blunt Thoracic Aortic Injuries (RESCUE)

Evaluation of the GORE Conformable TAG® Thoracic Endoprosthesis for Treatment of Acute Complicated Type B Aortic Dissection: TAG 08-01

Evaluation of the GORE TAG® Thoracic Endoprosthesis 45 mm for the Primary Treatment of Aneurysms of the Descending Thoracic Aorta (Protocol Number: TAG 06-02)

Evaluation of the GORE TAG® Thoracic Endoprosthesis for the Treatment of Complex Pathology of the Descending Thoracic Aorta (TAG 04-01)

Patient Long-term Follow-Up to Collect Data Following MR-Guided Focused Ultrasound Treatment of Uterine Fibroids with Enhanced Sonication Techniques

Prospective, Multicenter, Randomized Controlled Trial of Endovascular Aneurysm Repair Using a Bilateral Percutaneous Approach (PEVAR) vs. Standard Approach (SEVAR) Using the IntuiTrak Endovascular AAA Delivery System and the Prostar XL or Perclose ProGlide Suture-Mediated Closure System

Zenith® TX2™ THORACIC TAA Endovascular Graft Clinical Trial (Protocol No. 03-536)

Zenith® TX2™ THORACIC TAA Endovascular Graft Post-Approval Study

Adults with thoracic aneurysms wanted for stent study

A Clinical Study to Evaluate Safety of the ExAblate Model 2100 Type 1.1 System (ExAblate 2100/2200 UF V2 System) in the Treatment of Symptomatic Uterine Fibroids

Women with Symptomatic Uterine Fibroids are Needed for a Research Study

PI: Patrick Norton, M.D.

Assessment of Left Atrial Function by MRI Following Atrial Fibrillation Ablation

PI: Michael Salerno, M.D.

Improved cardiac risk stratification for liver transplantation using cardiac CT

Improved cardiac risk stratification for liver transplantation using cardiac CT


PI: James Stone, M.D.


VenaTech™ Convertible™ Vena Cava Filter U.S. Multi-Center Clinical Trial

Research study for those scheduled for vena cava filter placement

PI: Elias William (Jeff), M.D.

Database of patients interested in clinical trials involving Focused Ultrasound Surgery for Movement Disorders

Database of patients interested in clinical trials involving Focused Ultrasound Surgery for Movement Disorders

PI: Mark Williams, Ph.D.

Novel Systems for Molecular Breast Imaging

Pilot Study of Dual Modality Surgical Guidance for Non-Palpable Breast Lesions

Go to full list of clinical trials at UVA Health System >>