Jennie Z. Ma, Ph.D.
Dr. Jennie Ma is a Professor of Biostatistics at the University of Virginia, with a secondary appointment in Nephrology. Her research interests mainly focus on clinical outcomes research, longitudinal data analysis, survival analysis, and clinical trials. As a biostatistician, Jennie has collaborated with many clinical investigators and contributed significantly to a broad range of clinical and biomedical studies for over 20 years, such as research in nephrology, infection disease, cardiology, and drug addictions. In these studies, Jennie has provided pivotal biostatistical supports to every stage of the clinical and translational research, including study conception and design, acquisition of data, decision of appropriate and cutting-edge statistical methods, statistical analysis and interpretation, and scientific reporting. With sustaining efforts, she has authored and co-authored over 150 peer-reviewed publications including many top journals such as NEJM, JAMA, and Lancet. She has served on the Editorial Board for a clinical journal, as well as on the Protocol Review Board and the Data and Safety Monitoring Board for the Clinical Trials Network of NIDA, NIH.
Ph.D., University of Minnesota, Biostatistics
P.O. Box 800717
OMS Room 3871
Biostatistics in Clinical and Genetic Studies
Survival Analysis; longitudinal studies; statistical genetic association and linkage analysis; latent variable analysis and mixture modeling; bioinformatics; clinical trial design; meta-analysis
Wei J, Ma JZ, Payne TJ, Cui W, Ray R, Mitra N, Lerman C, Li MD (2010). Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers. Human Genetics. 127(6):691-8 [PMID: 20383528].
Ma JZ, Payne TJ, Li MD (2010). Significant association of glutamate receptor, ionotropic N-methyl-D: -aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers. Hum Genet. 127(5):503-12. [PMID: 20084518].
Huffmyer JL, Mauermann WJ, Thiele RH, Ma JZ, Nemergut EC (2009). Preoperative Statin Administration Is Associated With Lower Mortality and Decreased Need for Postoperative Hemodialysis in Patients Undergoing Coronary Artery Bypass Graft Surgery. Journal of Cardiothoracic and Vascular Anesthesia 23(4):468-73.
Liu L, Ma JZ, O'Quigley J (2008). Joint analysis of multi-level repeated measures data and survival: an application to the end stage renal disease (ESRD) data. Statistics in Medicine 27(27):5679-91.
Li MD, Lou XY, Chen G, Ma JZ, Elston RC (2008). Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence. Biological Psychiatry 64(11):951-7.
Liu L, Ma JZ, Johnson BA (2008). A multi-level two-part random effects model, with application to an alcohol-dependence study. Statistics in Medicine 27(18):3528-39.
Li MD, Ma JZ, Payne TJ, Lou XY, Zhang D, Dupont RT, Elston RC (2008). Genome-wide linkage scan for nicotine dependence in European Americans and its converging results with African Americans in the Mid-South Tobacco Family sample. Molecular Psychiatry 13(4):407-16.
Lou XY, Chen GB, Yan L, Ma JZ, Zhu J, Elston RC, Li MD (2007). A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. American Journal of Human Genetics 80:1125-1137. This paper has been picked for Faculty of 1000 in 2009.
Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K (2006). A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. New England Journal of Medicine 355(22):2297-307.
Ma JZ, Ait-Daoud N, Johnson BA (2006). Topiramate reduces the harm of excessive drinking: implications for public health and primary care. Addiction 101:1561-8.
Li MD, Payne TJ, Ma JZ, Lou X-Y, Zhang D, Dupont RT, Crews KM, Somes G, Williams NJ, and Elston RC (2006). A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African-Americans. American Journal of Human Genetics 79:745-751.
Ma JZ, Beuten J, Payne TJ, Dupont RT, Elston RC, and Li MD (2005). Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. Human Molecular Genetics 14(12):1691-8.
Ma JZ, Zhang D, Dupont RT, Dockter M, Elston RC, and Li MD (2003). Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure. BMC Genetics 4(suppl):S104.
Johnson BA, Ait-Daoud N, Ma JZ and Wang Y (2003). Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individuals. Alcoholism: Clinical and Experimental Research 27:1773-9.
Cheng R, Ma JZ, Wright FA, Lin S, Gao X, Wang D, Elston RC, and Li MD (2003). Nonparametric Disequilibrium Mapping of Functional Sites Using Haplotypes of Multiple Tightly Linked Single-Nucleotide Polymorphism Markers. Genetics 164: 1175-1187.
Johnson BA, Ait-Daoud N, Bowden CL, DiClemente CC, Roache JD, Lawson K, Javors MA, and Ma JZ (2003). Oral topiramate for treatment of alcohol dependence: a randomised controlled trial. Lancet 361:1677-85. This is one of the most cited papers in clinical trial study for the treatment of alcohol dependence. Based on the search conducted on January 31, 2011 with Google Scholar, this paper has been cited 383 times.
Herzog CA, Ma JZ and Collins AJ (2002). Long-term survival of dialysis patients in the United States with prosthetic heart valves: should ACC/AHA practice guidelines on valve selection be modified? Circulation 105(11): 1336-41.
Xue JL, Ma JZ, Louis TA, Collins AJ (2001). Forecast of the number of patients with end-stage renal disease in the United States to the year 2010. Journal of the American Society of Nephrology 12: 2753-8. (This publication has been listed as 38th of the 50 most-frequently cited articles by the Journal as of Nov 1, 2009, see http://jasn.asnjournals.org/reports/mfc_all_2.dtl). Based on the search conducted on January 31, 2011 with Google Scholar, this paper has been cited 369 times.
Herzog CA, Ma JZ and Collins AJ (1999). Outcomes associated with revascularization procedures. Kidney International 56: 324-32.
Ma JZ, Ebben J, Xia H and Collins AJ (1999). Hematocrit level and associated mortality in hemodialysis patients. Journal of the American Society of Nephrology 10: 610-619. (This publication has been listed as 26th of the 50 most-frequently cited articles by the Journal as of Nov 1, 2009, see http://jasn.asnjournals.org/reports/mfc_all_2.dtl). Based on the search conducted on January 31, 2011 with Google Scholar, this paper has been cited 429 times.
Herzog CA, Ma JZ and Collins AJ (1998). Poor long-term survival after Acute Myocardial Infarction among Patients on Long-Term Dialysis. New England Journal of Medicine 339: 799-805.
Kasiske BL, Guijarro C, Massy ZA, Wiederkehr MR and Ma JZ (1996). Cardiovascular disease after renal transplantation. Journal of the American Society of Nephrology 7: 158-165. (This publication has been listed as 34th of the 50 most-frequently cited articles by the Journal as of Nov 1, 2009, see http://jasn.asnjournals.org/reports/mfc_all_2.dtl). Based on the search conducted on January 31, 2011 with Google Scholar, this paper has been cited 526 times.
Kasiske BL, Ma JZ, Kalil RSN and Louis TA (1995). Effects of antihypertensive therapy on serum lipids. Annals of Internal Medicine 122: 133-141.
Kasiske BL, Heim-Duthoy K, and Ma JZ (1993). Elective cyclosporine withdrawal after renal transplantation: a meta-analysis. Journal of the American Medical Association 269:395-400.
Ma JZ, and Ackerman E (1993). Parameter sensitivity of a model of viral epidemics simulated with Monte Carlo techniques: II. Durations and peaks. International Journal of Bio-Medical Computing 32: 255-268.
Ma JZ, Ackerman E, and Yang JJ (1993). Parameter sensitivity of a model of viral epidemics simulated with Monte Carlo techniques: I. Illness attack rates. International Journal of Bio-Medical Computing 32: 237-253.