2011 - 2012 Fellows in Pathology

Fellows in Clinical Chemistry

Brian N. Kelly, Ph.D. (2009-2012)   PIC# 6140

Birthplace: Bethesda, MD

College: University of Colorado, Boulder, CO

Graduate School: University of Utah, Salt Lake City, UT

Interests in Pathology: Clinical Chemistry

Peer Reviewed Publications -

• X-ray structures of the hexameric building block of the HIV capsid. Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M. Cell. 2009 Jun 26;137(7):1282-92.
• Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. Kelly BN, Kyere S, Kinde I, Tang C, Howard BR, Robinson H, Sundquist WI, Summers MF, Hill CP. J Mol Biol. 2007 Oct 19;373(2):355-66.
• Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278). Kelly BN, Howard BR, Wang H, Robinson H, Sundquist WI, Hill CP. Biochemistry. 2006 Sep 26;45(38):11257-66.
• Ubiquitin recognition by the human TSG101 protein. Sundquist WI, Schubert HL, Kelly BN, Hill GC, Holton JM, Hill CP. Mol Cell. 2004 Mar 26;13(6):783-9.

Oral Presentations -

• Structure of HIV-1 CAN in Complex with CAP-1, an Assembly Inhibitor. Invited oral presentation at the 15th Conference on Retroviruses and Opportunistic Infections, 2008.

Poster Presentations -

• Structure of HIV-1 CA(NTD) in Complex with CAP-1 Poster presentation at the West Coast Protein Crystallography Workshop, Asilomar, California, 2007.
• Structural Studies on HIV-1 Gag Proteins Poster presentation at the Northwest Protein Crystallography Workshop, Seattle, Washington, 2006.
• Structural Studies on HIV-1 Gag Proteins Poster presentation at the 19th Meeting of Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design, National Institutes of Health, Bethesda, Maryland, 2005.

Marisa Meyers-Needham, Ph.D.  PIC# 2695

Birthplace: San Antonio, TX

College: University of Texas at Austin

Medical and Graduate School: Medical University of South Carolina, Charleston, SC

Interests in Pathology: Clinical Chemistry and Molecular Diagnostics, Cancer Biology

Peer Reviewed Publications -

• Marisa Meyers-Needham, Suriyan Ponnusamy, Salih Gencer, Wenhui Jiang, Raqulea Thomas, and Besim Ogretmen.  "Concerted functions of HDAC1 and miRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells"  Accepted for publication to EMBOJ Mol Med, Fall 2011.
• Marisa Meyers-Needham, Jocelyn A. Lewis, Salih Gencer, R. David Sentelle, Christopher J. Clarke, Yusuf A. Hannun, Haakan Norell, Telma Martins da Palma, Michael Nishimura, Jackie Kraveka, Zohreh Khavandgar, Monzur Murshed, and Besim Ogretmen.  "Off-Target Function of the Sonic-Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Neutral Sphingomyelinase 2/Ceramide Induction by Nitric Oxide Generation"  Submitted for publication to JBC, August 2011.
• Can E. Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers-Needham, Sahar A. Saddoughi, Paul Dent, Jacek Bielawski, and Besim Ogretmen.  "Deregulation of de novo ceramide generation controls activating transcription factor 6-mediated apoptosis via perturbation of cellular Ca+2 and ER/Golgi membrane network"  Submitted to JBC for publication, July 2011.
• Can E Senkal, Suriyan Ponnusamy, Yefim Manevich, Marisa Meyers-Needham, Sahar A Saddoughi, Paul Dent, Jacek Bielawski, and Besim Ogretmen.  "Selective activation of ATF-6 via alterations of cellular Ca+2 and ER/Golgi membrane network by deregulation of de novo ceramide"  Submitted to PNAS, June 2011.
• Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, Baran Y, Mahajan S, Fernandes D, Stuart R, Perrotti D, Ogretmen B.  "Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A." Blood 117(22):5941-52, 2011.
• Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B.  “Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance” Future Oncol 6(10):1603-24, 2010.

Abstract Presentations -

• “Characterization of Functional Promoter Regions of Human dihydroCeramide Synthase 1 (CerS1/LASS1) Gene in HNSCC”
• Charleston Ceramide Conference, Villars, Switzerland, Presentation, Spring 2011
• MUSC Dental Research Day – Charleston, SC, Poster, Winter 2011
• Hollings Cancer Center Retreat, Charleston, SC, Poster, Fall 2010
• Southeastern Regional Lipid Conference, Cashiers, NC, Presentation, Fall 2010
• Perry V. Halushka Student Research Day, Charleston, SC, Presentation, Fall 2010
• Hollings Cancer Center Retreat, Charleston, SC, Poster, Fall 2009
• Southeastern Regional Lipid Conference, Cashiers, NC, Poster, Fall 2009
• Perry V. Halushka Student Research Day, Charleston, SC,  Poster, Fall 2009
• Southeastern Regional Lipid Conference, Presentation, Cashiers, NC, Fall 2008
• Hollings Cancer Center Retreat, Charleston, SC, Poster, Fall 2008
• Southeastern Regional Lipid Conference, Cashiers, NC, Presentation, Fall 2007

Fellows in Cytopathology

Tanisha Hayes, D.O., M.B.S. PIC# 3946

Birthplace: Philadelphia

College: Temple University, PA

Medical School: University of Medicine and Dentistry of New Jersey - School of Osteopathic Medicine

Residency: Temple University Hospital AP/CP Pathology Residency

Interest in Pathology: Cytology

Peer Reviewed Publications -

• Bhavsar T, Hayes T, Wurzel J.  Coronary artery intimal fibrosis with fatal myocardial infarctions in a 22-year-old male user of cocaine and multiple other drugs.  CAP Annual Meeting, Sept 2010, Chicago, Illinois
• Bhavsar T, Hayes T, Wurzel J.  Intimal smooth muscle proliferation of mesenteric arterial branches complicated by fatal ischemic enterocolitis in a cocaine user.  CAP Annual Meeting, Sept 2010, Chicago, Illinois
• Gupta S, Hayes T, Liu Y, Hurford MT, Solomides C, Bromberg M.  Tissue Factor is Frequently Expressed in Multiple Myeloma Cells.  ASH Annual Meeting, Dec 2009, New Orleans, Louisiana
• Hayes, Tanisha. Why Medicine? Journal of Minority Medical Students. Fall 2004. 17 (1):68.
• Hayes, Tanisha. How is Medical School Different?  Journal of Minority Medical Students. Spring 2004. 16 (3).
• Society of Teachers of Family Medicine Northeast Regional Conference, Pittsburg, PA. Presenter- “How to Write a Cultural Medicine Paper”, October 2003

Fellows in Dermatopathology

Louis B. Brill, M.D., Ph.D.  PIC# 3111

Birthplace: Manassas, VA.

College: Johns Hopkins University, Baltimore, MD

Medical and Graduate School: University of Virginia School of Medicine, Charlottesville, VA

Residency: University of Virginia School of Medicine, Charlottesville, VA (AP/CP)

Interests in Pathology: Surgical Pathology, Molecular Pathology, Translational Research

Peer Reviewed Publications -

• Brill LB,II, Bennett JP Jr. Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP(+). Exp Neurol. 2003 May;181(1):25-38.
• Trotter SA, Brill LB, II, Bennett JP Jr. Stability of gene expression in postmortem brain revealed by cDNA gene array analysis. Brain Res. 2002 Jun 28;942(1-2):120-3.
• Brill LB,II, Pfister KK. Biochemical and molecular analysis of the mammalian cytoplasmic dynein intermediate chain. Methods. 2000 Dec;22(4):307-16.

Abstract Presentations -

• Louis Brill II, Scott T Eblen, Ammasi Periasamy3 Michael J Weber, James W Mandell. Protein-protein interactions in fixed cells and glial tumors revealed by antibody-based fluorescence resonance energy transfer. American Society for Investigative Pathology, San Francisco 2006.

William A. Kanner, M.D. PIC# 4140

Birthplace: Frankfurt, Germany.

College: Washington & Lee University, Lexington, VA

Medical School: University of Maryland School of Medicine, Baltimore, MD

Residency: University of Virginia, School of Medicine, Charlottesville, VA (AP/CP)

Interests in Pathology: Dermatopathology, Transfusion Medicine.

Peer Reviewed Publications -

• Brill LBII, Kanner WA, Moskaluk CA, Andren Y, Fehr A, Stenman G and Frierson HF. Examination of MYB in Adenoid Cystic Carcinoma and Other Neoplasms of the Head & Neck. Accepted to Modern Pathology.
• Deng M, Nair LS, Nukavarapu SP, Jiang T, Kanner WA, Li X, Kumbar SG, Weikel AL, Krogman NR, Allcock HR, Laurencin CT. Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering. Biomaterials. 2010 Jun;31(18):4898-908. Epub 2010 Mar 23.
• Kanner WA, Brill LB 2nd, Patterson JW, Wick MR. CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan Pathol. 2010 Jul;37(7):744-50. Epub 2010 Feb 24.
• Kanner WA, Galgano MT, Atkins KA. Podoplanin expression in basal and myoepithelial cells: utility and potential pitfalls. Appl Immunohistochem Mol Morphol. 2010 May;18(3):226-30.
• Kanner WA, White KP, Barry CI, Lee AJ, Cousar JB, Wick MR, Patterson JW.  Cutaneous T-cell Lymphoma Occurring with a Melanocytic Proliferation, Masquerading as a Non-Healing Ulcer with Reactive Changes. J Cutan Pathol. 2011 Jan;38(1):67-72.
• Kanner WA, Jeffus S, Wehrli G. An Academic-Based Hospital Donor Site: Do Physicians Donate Blood? Annals of Clinical & Laboratory Science, vol. 39, no. 4, 2009.
• Kanner WA, Saleh, KJ, Frierson HF. Reassessment of the Utility of Frozen Section Analysis for Hip and Knee Joint Revisions. Am J Clin Pathol. 2008 Sep;130(3):363-8.
• Kanner WA, Galagano MT, Stoler, MH, Mills, SE, Atkins, KA. Distinguishing Breast Carcinoma from Müllerian Serous Carcinoma with Mammaglobin and Mesothelin. Int J Gynecol Pathol. 2008 Oct;27(4):491-5.
• Kanner WA,  Wang S, Meltzer SJ, Sklar GN, Drachenberg, CB, Papadimitriou JC. Penile Urethral Stromal Tumor with Pacemaker Cell Phenotype. Ultrastructural Pathology, 2007 Jan-Feb;31(1):63-71.
• Lynn M, Kleinhenz D, Thorson H, Kanner W, Dudley S, Hart CM. Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway. Journal of Investigative Medicine. 2004 Vol. 52, 129-136.
• Cai H, Li Z, Davis ME, Kanner W, Harrison DG, Dudley SC Jr. Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol Pharmacol. 2003 Feb;63(2):325-31.
• Chattopadhyay S, Kanner WA, Chakrabarti J. DNA Nucleotides : A case study of evolution. Eur. Phys. J. B. 2002 26, 393-398.

Abstract Presentations -

• Brill LBII, Kanner WA, Moskaluk CA, Andren Y, Fehr A, Stenman G and Frierson HF. Examination of MYB in Adenoid Cystic Carcinoma and Other Neoplasms of the Head & Neck United States and Canadian Academy of Pathology. Poster Presentation 2011.
• WA Kanner, S Jeffus, J Moore, G Wehrli. RBC Unit ABO Discrepancies from the Blood Bank to the Transfusion Service.  American Association for Blood Bank. Poster Presentation 2010.
• WA Kanner, MB Lopes, RD LeGallo. Sudden Demise in a 37-Week-Old Male Infant due to D-Transposition of Great Vessels with a Closed Foramen Ovale. United States and Canadian Academy of Pathology. Poster Presentation 2010.
• WA Kanner, CI Barry, CN Smart, DP Frishberg, SW Binder and MR Wick. Reticulin and NM23 Staining in the Interpretation of Lymph Nodal Nevus Rests. United States and Canadian Academy of Pathology. Poster Presentation 2010.
• Kanner WA, White KP, Barry CI, Lee AJ, Cousar JB, Wick MR, Patterson JW.  Cutaneous T-cell Lymphoma Occurring with a Melanocytic Proliferation, Masquerading as a Non-Healing Ulcer with Reactive Changes. American Society for Dermatopathology. Poster Presentation 2008.
• Kanner WA, Wehrli, G. An Academic-Based Hospital Donor Site: Who is in the Donor Chair?  American Association for Blood Bank. Poster Presentation 2008.
• Park J, Padia SH, Kanner WA, Carey RM. Vasoactive Intestinal Peptide-Secreting Adrenal Pheochromocytoma. Endocrine Society. Poster Presentation 2008.
• Kanner WA, Saleh KJ, Frierson HF. Reassessment of the Utility of Frozen Section Analysis for Hip and Knee Joint Revisions. United States and Canadian Academy of Pathology. Poster Presentation 2008.
• Kanner WA, Atkins KA. Podoplanin Expression in Myoepithelial Cells and Basal Cells in Breast and Prostate Tissue; Utility and Potential Pitfalls. United States and Canadian Academy of Pathology. Poster Presentation 2008.
• Kanner WA, Galagano MT, Stoler, MH, Mills, SE, Atkins, KA. Distinguishing Breast Carcinoma From Mullerian Serous Carcioma with Mammaglobin and Mesothelin.United States and Canadian Academy of Pathology. Poster Presentation 2008.
• Javorsky BR, Thorner MO, Carey RM, Kanner WA, Orth DN, Stratakis CA, Malchoff CD, Malchoff DM, Aloi JA. Two "Hits" to Cushing's Syndrome:  Carney Complex and ACTH Receptor Mutations in the same individual. American College of Physicians Poster Presentation 2008.
• Kanner WA, Drachenberg, CB, Papadimitriou JC. Interstitial cell penile urethral stromal tumor: A pacemaker cell phenotype. International Academy of Pathology. Poster Presentation 2006.
• Kanner WA, Dudley S. ω-3 Fatty Acids Modulate Insulin-Stimulated Endothelial Cell Nitric Oxide Production. American College of Physicians. Poster Presentation 2003.

Grant/Contract -

Co-investigator, Salivary Gland Tumor Biorepository.  NIH contract with MD Anderson.

Jennifer Reese, M.D., PIC #4483

Birthplace:  Baltimore, MD

College:  Towson University, Towson, MD

Medical School:  University of Maryland School of Medicine, Baltimore, MD

Residency:  Hospital of the University of Pennsylvania, Philadelphia, PA

Interests in Pathology:  Dermatopathology, Melanocytic lesions

Peer Reviewed Publications -

• Reese JM, Phillips D, Brown JA, Papadimitriou JC. Metastatic carcinoma within a foreign-body reaction to vegetable matter: a pseudo-pseudomalignancy. International Journal of Surgical Pathology 2008; 16: 59-61.

Abstract Presentations -

• Nakashima MO, Reese JM.  Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma. To be presented on the workshop case server at the Society for Hematopathology and European Association for Hematopathology Workshop, 2011, Los Angeles, California.
• Reese JM, Rosenbach M, Miller C, Rubin AI. Amyloidosis: an unrecognized cause of basement membrane alteration. Presented at the 47th Annual Meeting of The American Society of Dermatopathology, 2010, Atlanta, Georgia.

• Reese JM, Rubin AI. Onychotillomania: Clinicopathologic Correlations. Presented at the 47th Annual Meeting of The American Society of Dermatopathology, 2010, Atlanta, Georgia.

• Reese JM, Reilly G, Elenitsas R. Merkel Cell Carcinoma In-Situ. Presented at the 46th Annual Meeting of The American Society of Dermatopathology, 2009, Chicago, Illinois.

• Reese JM, Elenitsas R, Rubin AI. Hidden Melanomas: A dermatopathology danger zone. Presented at the 46th Annual Meeting of The American Society of Dermatopathology, 2009, Chicago, Illinois.

• Reese JM, Elenitsas R, Rubin AI. Hidden Melanomas: A dermatopathology danger zone. Presented at the 46th Annual Meeting of The American Society of Dermatopathology, 2009, Chicago, Illinois.

Fellow in Gynecological Pathology

Sarah R. Nassau, M.D. PIC# 3012

Birthplace: Portsmouth, VA.

College: College of William and Mary, Williamsburg, VA.

Medical School: University of Virginia, School of Medicine, Charlottesville, VA.

Interests in Pathology: Cytopathology

Fellow in Hematopathology

Michael W. Cruise, M.D., Ph.D.  PIC# 3465

Birthplace: Mount Airy, NC

College: George Mason University, Fairfax, VA

Medical and Graduate School: University of Virginia, School of Medicine, Charlottesvile, VA.

Peer Reviewed Publications -

• Lukens JR, Cruise MW, Lassen MG, Hahn YS. Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. J Immunol. 2008 Apr 1;180(7):4875-84.
• Cruise, MW. Lukens, J. Nguyen, AP. Lassen, MG. Landes, S. Hahn, YS. Fas ligand of CD4+ T cells induced by HCV core is responsible for chemokine production and hepatic damage. J of Immunology. May 2006; 176: 6235-44.
• Cruise, MW. Lukens, J. Hahn, YS. Hepatitis C Virus's Immune Evasion Strategies. Current Immunology Review. Vol 1 issue 3 Nov 2005; 1(3): 223-235.
• Waggoner, SN, Cruise, MW. Kassel, R. Hahn, YS. gC1qR ligation selectively downregulates human interleukin-12 production through activation of the phosphoinositide-3 kinase pathway. J of Immunology. Oct 2005; 175(7): 4706-14.
• Cruise, MW. Melief, H. Soguero, C. Lukens, J. Hahn, YS. Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation and damage. J of Leukocyte Biology. Aug 2005; 78: 412-425. Cover Art same issue.
• Hahn, YS. Soquero, C. Cruise, MW. Towards a reliable parameter of liver damage in hepatitis C: TUNEL versus caspase activation. Hepatology. Vol 34(4). Oct 2001 840-841. Editorial Review.

Fellows in Neuropathology

Heather M. Sumner, M.D.  PIC# 2176

Birthplace: Tifton, GA.

College: Valdosta State University, Valdosta, GA.

Medical School: Mercer University School of Medicine, Macon, GA.

Interests in Pathology: Cytopathology

Fellows in Transfusion Medicine

Susanne K. Jeffus, M.D. PIC# 4879

Birthplace: Rudolstadt, Germany

College: Ouachita Baptist University, Arkadelphia, AR

Graduate School: University of Arkansas, Fayetteville, AR

Medical School: University of Arkansas for Medical Sciences, Little Rock, AR

Interests in Pathology: Cytopathology, Transfusion Medicine

Peer Reviewed Publications -

• Jeffus, S, Iezzoni, J. “15-year-old male with a right palmar epithelioid sarcoma.” Accepted for publication to USCAP as Anatomic Pathology Electronic Case Series (APECS), 2010.

• Jeffus, S, Bourne, TD, Lopes, MB. "A 58-year-old woman with a corpus callosum nodule at autopsy" Brain Pathol. 2009 Oct;19(4):743-4.
• Kanner, WA, Jeffus, S, Wehrli G. An Academic-Based Hospital Donor Site: Do Physicians Donate Blood? Annals of Clinical & Laboratory Science, vol. 39, no. 4, 2009.

Abstract Presentations-

• Kanner WA, Jeffus S, Moore J, Wehrli G. “RBC Unit ABO Discrepancies from the Blood Bank to the Transfusion Service.” Abstract Presentation at 2010 AABB Meeting
• Jeffus S, Nagji A, Kozower B, Jones D, Stelow E. “Assessing the Pleura and Other Objective and Routine Findings Predicting Outcome with Stage 1 Non-Small Cell Lung Carcinoma.” Abstract Presentation at USCAP 2011

Book Chapters -

• Lung, Pancreas, and Mediastinum Chapter in: Cruise, M., Brix, W., Jeffus, S., Sutton, J., Lutterbie, Y., Nassau, S., and Stanley, D. “Compendium to Surgical Pathology.” Submitted for publication by the ASCP Press.

Kimberly W. Sanford, M.D.   PIC#

College: Virginia Commonwealth University, Medical College of Virginia, Richmond, VA

Medical School: Virginia Commonwealth University, Medical College of Virginia, Richmond, VA

Residency: Virginia Commonwealth University, Medical College of Virginia, Richmond, VA (AP/CP)

Interests in Pathology: Transfusion medicine, therapeutic apheresis, serology, immunohematology, hematopathology.