Tung Lab Research Opportunities
Title: Professor of Pathology, Professor of
Contact: Kenneth Tung, M.D. kst7k@Virginia.EDU
Factors responsible for immunological self tolerance and autoimmune disease development. Focus is on 1) regulatory T cell response to endogenous self antigens, and 2) mechanism of autoimmune inflammation.
- Ontogeny and accessibility of self Ag in tolerance induction.
- Mechanism of immune privilege.
- Antigen specific natural regulatory T cells as mechanism of tolerance.
- Epitope spreading in autoimmune disease.
What you will learn from this rotation:
- Adult and neonatal experimental autoimmune diseases.
- Mouse immunogenetics
- Autoantibody detection.
- Antigen specific T cell detection and functional analysis.
- Isolation of leukocyte subsets.
- Flow cytometric analysis of leukocytes.
- Mouse surgery.
- Transgenic models of autoimmunity.
- Imbalance of regulatory and effector T cell function determines autoimmune disease pathogenesis.
- Endogenous antigens are critical in regulating tolerance and autoimmunity.
- Propensity of neonatal mice to autoimmune response and disease.
- Early immunological events prime individuals for late onset autoimmunity.
- Factors that obscure the detection of target autoantigen and disease mechanism.