Tung Lab Research Opportunities

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Tung Lab Research Opportunities

 

TungTitle: Professor of Pathology, Professor of Microbiology
Contact: Kenneth Tung, M.D. kst7k@Virginia.EDU

Laboratory interests:
Factors responsible for immunological self tolerance and autoimmune disease development. Focus is on 1) regulatory T cell response to endogenous self antigens, and 2) mechanism of autoimmune inflammation.

 



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Research projects:

  1. Ontogeny and accessibility of self Ag in tolerance induction.
  2. Mechanism of immune privilege.
  3. Antigen specific natural regulatory T cells as mechanism of tolerance.
  4. Epitope spreading in autoimmune disease.

What you will learn from this rotation:

  1. Adult and neonatal experimental autoimmune diseases.
  2. Mouse immunogenetics
  3. Autoantibody detection.
  4. Antigen specific T cell detection and functional analysis.
  5. Isolation of leukocyte subsets.
  6. Flow cytometric analysis of leukocytes.
  7. picture2.jpgImmunohistology.
  8. Mouse surgery.
  9. Transgenic models of autoimmunity.

Principles:

  • Imbalance of regulatory and effector T cell function determines autoimmune disease pathogenesis.
  • Endogenous antigens are critical in regulating tolerance and autoimmunity.
  • Propensity of neonatal mice to autoimmune response and disease.
  • Early immunological events prime individuals for late onset autoimmunity.
  • Factors that obscure the detection of target autoantigen and disease mechanism.