Dennis J. Templeton, M.D., Ph.D.

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Dennis J. Templeton, M.D., Ph.D.

 

 

Templeton

Dennis J. Templeton, M.D., Ph.D.

Professor and Chair



CLINICAL:

Application of stress inhibitory compounds as adjuvant cancer therapeutic agents. I am also developing means by which tumors of individual patients can be categorized as responsive or resistant to growth inhibition by stress-inducing therapies.

 RESEARCH:

My work focuses on the intracellular mechanisms of signal transduction, particularly those that transmit signals originating with physical stress and inflammatory cytokines.

REFERENCES:

  • Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR and Templeton DJ. (1994) Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372: 798-800. (482) 
  • Mahalingam M, Templeton DJ. Constitutive activation of S6 kinase 1 by deletion of amino-terminal autoinhibitory and rapamycin sensitivity domains. Mol Cell Biol, 1996. 16(1):405-13.
  • Deak JC, Templeton DJ. Regulation of the activity of MEK kinase 1(MEKK1) by autophosphorylation within the kinase activation domain. Biochem J, 1997. 322(Pt1):185-92.
  • Natoli G, Costanzo A, Ianni A, Templeton DJ, Woodgett J, Balsano C, and Levrero M. (1997) Activation of SAPK/JNK by TNF Receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 275: 200-203. (172)
  • Deak JC, Cross JV, Lewis M, Qian Y, Parrott LA, Distelhorst CW, and Templeton DJ. (1998) Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc Natl Acad Sci USA 99: 5595-5600. (35)
  • Parrott LA and Templeton DJ. (1999) Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase. J Biol Chem 274: 24731-6. (4)
  • Cross JV, Deak JC, Rich EA, Qian Y, Lewis M, Parrott LA, Mochida K, Gustafson D, Vande Pol S, and Templeton DJ. (1999) Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis. J Biol Chem 274: 31150-4. (1)
  • Goss VL, et al. SAPK/JNK regulates cdc2/cyclin B kinase through phosphorylation and inhibition of cdc25c. Cell Signal , 2003. 15(7): p. 709-18.
  • Seanor KL, et al. Reactive Quinones Differentially Regulate SAPK/JNK and p38/mHOG Stress Kinases. Antioxid Redox Signal , 2003. 5(1): p. 103-13.
  • Cross JV, Templeton DJ. Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP binding domain. Biochem J , 2004. PMID: 15139 (in press).
  • Cross JV, Templeton DJ. Thiol Oxidation of Cell Signaling Proteins: Controlling an Apoptotic Equilibrium. J Cell Bochem, 2004 (in press).

A more complete list of Dr. Templeton's publications can be obtained from Pubmed.