Mark H. Stoler, M.D.

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Mark H. Stoler, M.D.

Mark H. Stoler, M.D. Faculty Profile


Mark H. Stoler, M.D. 

Professor of Pathology, Cytology and Gynecology 

Associate Director of Surgical Pathology and Cytopathology

Director of Gynecological Pathology Fellowship Program



Medical School: University of Rochester, MD, 1980
Residency: University of Rochester Medical Center, 1980 - 1984
Fellowship: Fellow in Surgical and Cytopathology, University of Rochester Medical Center, 1984 - 1985


Cytopathology, Gynecologic Pathology, Hematopathology, Pulmonary and General Surgical Pathology and Diagnostic Molecular Pathology


Our research is directed at the application of molecular biologic methods, primarily in situ hybridization, to the study of gene expression in human disease. Areas of interest include viral carcinogenesis and the modulation of cellular gene expression in a variety of inflammatory and neoplastic states. Refinement of the role of molecular methods as diagnostic adjuncts to anatomic pathology practice is also under active investigation, as is the provision of reference level pathology for the support of clinical trials involving both diagnostics and therapy.


  • Lachance JA, Shutter J, Atkins KA, Stoler MH, Rice LW, Jazaeri AA. Utilization of a uniform grading system for interpreting serous ovarian cancer. Am J Obstet Gynecol 2008.
  • Galgano MT, Castle PE, Stoler MH, Solomon D, Schiffman M. Can HPV-16 Genotyping Provide a Benchmark for Cervical Biopsy Specimen Interpretation? Am J Clin Pathol 2008;130(1):65-70.
  • Chute DJ, Cousar JB, Mahadevan MS, Siegrist KA, Silverman LM, Stoler MH. Detection of immunoglobulin heavy chain gene rearrangements in classic hodgkin lymphoma using commercially available BIOMED-2 primers. Diagn Mol Pathol 2008;17(2):65-72.
  • Young JL, Jazaeri AA, Lachance JA, Stoler MH, et al. Cervical adenocarcinoma in situ: the predictive value of conization margin status. Am J Obstet Gynecol 2007;197(2):195 e1-7; discussion  e7-8.
  • Solomon D, Stoler M, Jeronimo J, Khan M, Castle P, Schiffman M. Diagnostic utility of endocervical curettage in women undergoing colposcopy for equivocal or low-grade cytologic abnormalities. Obstet Gynecol 2007;110(2 Pt 1):288-95.
  • Covell JL, Stoler MH. Human papillomavirus testing, vaccination, and gynecologic screening: fight or flight? Am J Clin Pathol 2007;128(5):726-8. 
  • Castle PE, Stoler MH, Solomon D, Schiffman M. The Relationship of Community Biopsy-Diagnosed Cervical Intraepithelial Neoplasia Grade 2 to the Quality Control Pathology-Reviewed Diagnoses:An ALTS Report. Am J Clin Pathol. May 2007;127(5):805-815.  
  • Stoler MH. ASC, TBS, and the Power of ALTS. Am J Clin Pathol. Apr 2007;127(4):489-491  
  • Stoler MH, Castle PE, Solomon D, Schiffman M. The expanded use of HPV testing in gynecologic practice per ASCCP-guided management requires the use of well-validated assays. Am J Clin Pathol. Mar 2007;127(3):335-337.
  • Kibiki GS, Myers LC, Kalambo CF, Hoang SB, Stoler MH, Stroup SE, Houpt ER. Bronchoalveolar neutrophils, interferon gamma-inducible protein 10 and interleukin-7 in AIDS-associated tuberculosis. Clin Exp Immunol. Feb 6 2007. 
  • Walker JL, Wang SS, Schiffman M, Solomon D. Predicting absolute risk of CIN3 during post-colposcopic follow-up: results from the ASCUS-LSIL Triage Study (ALTS). Am J Obstet Gynecol. Aug 2006;195(2):341-348. 
  • Villa LL, Ault KA, Giuliano AR, Costa RL, Petta CA, Andrade RP, Brown DR, Ferenczy A, Harper DM, Koutsky LA, Kurman RJ, Lehtinen M, Malm C, Olsson SE, Ronnett BM, Skjeldestad FE, Steinwall M, Stoler MH, Wheeler CM, Taddeo FJ, Yu J, Lupinacci L, Railkar R, Marchese R, Esser MT, Bryan J, Jansen KU, Sings HL, Tamms GM, Saah AJ, Barr E. Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18. Vaccine. Jul 7 2006;24(27-28):5571-5583. 
  • Stoler M. HPV Testing, If it's not clinically valid, it's dangerous HPV Today. Vol 9; 2006:4-5.
  • Srodon M, Stoler MH, Baber GB, Kurman RJ. The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN). Am J Surg Pathol. Dec 2006;30(12):1513-1518.
  • Gage JC, Hanson VW, Abbey K, Dippery S, Gardner S, Kubota J, Schiffman M, Solomon D, Jeronimo J. Number of cervical biopsies and sensitivity of colposcopy. Obstet Gynecol. Aug 2006;108(2):264-272.
  • Cooper B, Brimer N, Stoler M, Vande Pol SB. Suprabasal overexpression of Beta-1 integrin is induced by bovine papillomavirus type 1. Virology. Aug 7 2006.
  • Sherman ME, Carreon JD, Schiffman M. Performance of cytology and human papillomavirus testing in relation to the menstrual cycle. Br J Cancer. Jun 5 2006;94(11):1690-1696.
  • Atkins KA, Jeronimo J, Stoler MH. Description of patients with squamous cell carcinoma in the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion triage study. Cancer. May 5 2006.
  • Acharya KK, Govind CK, Shore AN, Stoler MH, Reddi PP. cis-Requirement for the maintenance of round spermatid-specific transcription. Dev Biol. May 3 2006.
  • Rice LW, Stone RL, Xu M, Galgano M, Stoler MH, Everett EN, Jazaeri AA. Biologic targets for therapeutic intervention in endometrioid endometrial adenocarcinoma and malignant mixed mullerian tumors. Am J Obstet Gynecol. Apr 2006;194(4):1119-1126; discussion 1126-1118. 
  • Sherman ME, Castle PE, Solomon D. Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes. Cancer. Mar 16 2006.
  • Ferris DG, Litaker MS. Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS. Am J Obstet Gynecol. Mar 2006;194(3):704-710.
  • Kulasingam SL, Kim JJ, Lawrence WF, Mandelblatt JS, Myers ER, Schiffman M, Solomon D, Goldie SJ. Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS). J Natl Cancer Inst. Jan 18 2006;98(2):92-100.
  • Cathro H, Stoler MH. The Role of Cytokeratin Immunohistochemistry in the Differential Diagnosis  of Ovarian Tumors. In: Hayat MA, ed. Immunohistochemistry and in situ hybridization of human carcinomas: Elsevier Science/Academic Press; 2006.
  • Zuna RE, Wang SS, Rosenthal DL, Jeronimo J, Schiffman M, Solomon D. Determinants of human papillomavirus-negative, low-grade squamous intraepithelial lesions in the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesions triage study (ALTS). Cancer. Oct 25 2005;105(5):253-262.
  • Villa LL, Costa RL, Petta CA , et al. Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol. May 2005;6(5):271-278.
  • Stoler MH. HPV testing in cervical cytology practice: it's all about choice. Acta Cytol. Mar-Apr 2005;49(2):117-119.
  • Stoler M. Cervical Cancer Screening in the HPV Era: What Is the Standard of Care? Medscape Pathology and Laboratory Medicine; 2005.
  • Stoler M. The Impact of Human Papillomavirus Biology on the Clinical Practice of Cervical Pathology. Pathology Case Reviews. May/June 2005 2005;10(3):119-127.
  • Stoler M. Cervical cancer screening in the molecular era: Change is in the air. Medscape Conference Coverage of the American Society for Clinical Pathology 2004 Annual Meeting. Medscape Pathology & Lab Medicine. 2005.
  • Downs-Kelly E, Yoder BJ, Stoler M, et al. The influence of polysomy 17 on HER2 gene and protein expression in adenocarcinoma of the breast: a fluorescent in situ hybridization, immunohistochemical, and isotopic mRNA in situ hybridization study. Am J Surg Pathol. Sep 2005;29(9):1221-1227.
  • Irvin W, Evans SR, Andersen W, et al. The utility of HPV DNA triage in the management of cytological AGC. Am J Obstet Gynecol. Aug 2005;193(2):559-565; discussion 565-557. 
  • Knoell KA, Hendrix JD, Jr., Stoler MH, Patterson JW, Montes CM. Absence of human herpesvirus 8 in sarcoidosis and crohn disease granulomas. Arch Dermatol. Jul 2005;141(7):909-910.
  • Cathro HP, Stoler MH. The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors. Hum Pathol. Feb 2005;36(2):195-201.
  • Stoler MH, Mills SE, Frierson HF. The Vulva and Vagina. In: Mills SE, ed. Diagnostic Surgical Pathology, Fourth Edition. Philadelphia : Lippincott, Williams & Wilkins; 2004.
  • Stoler MH. The Pathology of Cervical Neoplasia. In: Rohan T, Shah K, eds. Cervical Cancer: From Etiology to Prevention: Springer; 2004.
  • Seidman JD, Soslow RA, Vang R, et al. Borderline ovarian tumors: diverse contemporary viewpoints on terminology and diagnostic criteria with illustrative images. Hum Pathol. Aug 2004;35(8):918-933.
  • Bell DA, Longacre TA, Prat J, et al. Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: workshop perspectives. Hum Pathol. Aug 2004;35(8):934-948. 
  • Stoler MH. Introduction to symposium: "Tales From the Duct". Diagn Cytopathol. Mar 2004;30(3):139.
  • Mills SE, Carter D, Greenson J, Oberman H, Reuter V, Stoler MH, eds. Diagnostic Surgical Pathology, Fourth Edition. Philadelphia : Lippincott, Williams & Wilkins; 2004.
  • Lyons LL, North PE , Mac-Moune Lai F, Stoler MH, Folpe AL, Weiss SW. Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma. Am J Surg Pathol. May 2004;28(5):559-568.
  • Irvin W, Flora S, Andersen W, Stoler M, Taylor P, Rice L. Endocervical curettage. Does it contribute to the management of patients with abnormal cervical cytology? J Reprod Med. Jan 2004;49(1):1-7.
  • Cerilli LA, Wick MR, Stoler MH. Sarcomatoid Neoplasms of the Lungs and Pleural Surfaces. In: Leslie KO, Ritter JH, Wick MR, eds. Diagnostic Pulmonary Pathology: Churchill Livingstone; 2004.
  • Cathro H, Stoler MH. The Role of Cytokeratin Immunohistochemistry in the Differential Diagnosis  of Ovarian Tumors. In: Hayat MA, ed. Immunohistochemistry and in situ hybridization of human carcinomas: Elsevier Science/Academic Press; 2004.
  • Stoler MH. Two roads for HPV testing, but only one is heavily traveled(interview). CAP Today. Vol 17; 2003.
  • Reddi PP, Shore AN, Shapiro JA, Anderson A, Stoler MH, Acharya KK. Spermatid-specific promoter of the SP-10 gene functions as an insulator in somatic cells. Dev Biol. Oct 1 2003 ;262(1):173-182. 
  • Stoler MH. The virology of cervical neoplasia: an HPV-associated malignancy.Cancer J. Sep-Oct 2003;9(5):360-367.
  • Stoler MH. Testing for human papillomavirus: data driven implications for cervical neoplasia management. Clin Lab Med. Sep 2003;23(3):569-583, v.
  • Stoler MH. Human papillomavirus biology and cervical neoplasia: implications for diagnostic criteria and testing. Arch Pathol Lab Med. Aug 2003;127(8):935-939.

A current list of Dr. Stoler's journal publications can be obtained from PubMed.