Lawrence M. Silverman, Ph.D.

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Lawrence M. Silverman, Ph.D.

Lawrence M. Silverman, Ph.D. Faculty Profile

Lawrence M. Silverman, Ph.D.

Professor of Pathology

Scientific Director of Molecular Diagnostics Laboratory

Director of Davis Immunology Laboratory 


Molecular diagnostics of inherited and acquired disorders.


Modifier genes in cystic fibrosis; developing technologies in genomics and proteomics; epigenetics.


  • Consensus Characterization of 16 FMR1 Reference Materials: A Consortium  Study by the Fragile Xperts.  J Mol. Diagnostics. In Press.
  • Margaret L. Gulley, MD; Rita M. Braziel, MD; Kevin C. Halling, MD, PhD; Eric D. Hsi, MD; Jeffrey A. Kant, MD, PhD; Marina N. Nikiforova, MD; Jan A. Nowak, MD, PhD; Shuji Ogino, MD, PhD; Andre Oliveira, MD; Herbert F. Polesky, MD; Lawrence Silverman, PhD; Raymond R. Tubbs, DO; Vivianna M. Van Deerlin, MD, PhD; Gail H. Vance, MD; James Versalovic, MD, PhD; for the Molecular Pathology Resource Committee, College of American Pathologists. Clinical Laboratory Reports in Molecular Pathology.  Archives of Pathology and  Laboratory Medicine: Vol. 131, No. 6, pp. 852-863, 2006.
  • Silverman, LM, and Mifflin TE, Genotype-Phenotype Correlations (II): Assessing the Influence of Sequence  Variants on the Clinical Phenotype in Multifactorial Disorders. Clin Chem 51, 929-930, 2005.
  • Silverman, LM and Mahadevan M. Genotype-Phenotype Correlations: Assessing the influence of sequence variants on the clinical phenotype. Clin Chem 51, #1, 8, 2005.
  • Highsmith, WE, Friedman, KF, Silverman, LM, and Knowles, MR. A mutation (D1152H) in CFTR with mild lung disease and normal sweat chloride. Clinical Genetics  Clin Genet, 68: 88-90, 2005
  • Sugarman, EA, Rohlfs, EM, Silverman, LM, and Allitto, BA. CFTR mutation distribution among U.S. Hispanic and African-American individuals: Evaluation in cystic fibrosis patient and carrier screening populations. Genetics in Medicine, 6(#5), 392-399 2004.
  • Shaheen, NJ, Silverman, LM, Keku,T, Lawrence LB, Rohlfs, EM, Martin, CF, Galenko, J, and Sandler, RS. Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. J National Cancer Institute, 95 (#2), 154-159, 2003.
  • Hurford MT, Marshall-Taylor C, Vicki SL, Zhou JZ, Silverman LM, Rezuke WN, Altman A, Tsongalis GJ. A novel mutation in exon 5 of the ALAS2 gene results in X-linked sideroblastic anemia. Clin Chim Acta. 2002 Jul; 321(1-2):49-53.
  • Rohlfs, EM, Zhou, A, Sugarman, EA, Heim, RA, Pace, RG, Knowles, MR, Silverman, LM, and Allitto, BA. The I148T CFTR Mutations Confers a Variable Phenotype and Occurs on Multiple Haplotypes. Genetics in Medicine. 4(5), 2002, 319-323.

    A current list of Dr. Silverman's journal publications can be obtained from PubMed