James W. Mandell, M.D.

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James W. Mandell, M.D.

James W. Mandell, M.D. Faculty Profile

 

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James W. Mandell, M.D., Ph.D.

Professor, Division of Neuropathology
Member, Neuroscience Graduate Program
Associate Director for Curriculum, Medical Scientist Training Program



EDUCATION:

Medical School: M.D./Ph.D. Cornell University Medical College, New York, NY.  MD, 1992
 
Graduate School: Postdoctoral Fellow,  Department of Neuroscience, Laboratory of Dr. Gary Banker, University of Virginia, 1992 - 1994 

Residency: Anatomic Pathology, University of Virginia, 1994 - 1996

Fellowship: Fellow, Neuropathology, University of Virginia, 1996 - 1998  

CLINICAL:

Clinical Interests:
Surgical and Autopsy Diagnostic Neuropathology
Neuromuscular Pathology
Ophthalmic Pathology
In addition to shared coverage of the Diagnostic Surgical and Autopsy Neuropathology service, I am the sole faculty member responsible for all neuromuscular biopsy diagnosis as well as for all ophthalmic pathology  diagnosis. 


RESEARCH:

Currently my research program has two funded projects.  The first is focused on discovering and validating biomarkers of synaptic degeneration, using a global proteomics screening platform.  The second seeks to identify novel biomarkers of inflammatory myopathies, especially inclusion body myositis, focusing on noncoding RNAs that can be detected both in muscle biopsies as well as in the circulation.  We have developed a novel multiplex immunhistochemistry platform (patent application pending) that should have broad utility in anatomic pathology and seek new collaborative projects.

  

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REFERENCES:

  • McFarland KL, Wilkes, SR, Koss, SF, Ravichandran K, and Mandell JW*. Neural-specific inactivation of ShcA in the nervous system causes neural progenitor apoptosis and microcephaly. J Neurosci. 2006 26:7885-97.   
  • Hamilton DK, Bourne TD, Ahmed H, Cousar JB, Mandell JW, Sheehan JP*.Follicular lymphoma of the dura: case report.  Neurosurgery. 2006 Sep;59(3):E703. 
  • Bourne TD, Mandell JW,  Matsumoto JA., Jane JA, Lopes MB*. Primary disseminated leptomeningeal oligodendroglioma with chromosome 1p deletion. J Neurosurg. 2006.  105:465-9. 
  • Correa-Cerro LS, Mandell JW. Molecular mechanisms of astrogliosis: new approaches with mouse genetics.  J Neuropathol Exp Neurol. 2007 66(3):169-76. Review.
  • Favero CB and Mandell JW*.  A pharmacological activator of
  • AMP-activated kinase induces astrocyte stellation”. Brain Research 2007  1168:1-10 
  • Park, D., A.C. Tosello-Trampont, M.R. Elliott, Z. Ma, M. Lu, L. Haney, J.W. Mandell, A. Klibanov, K.S. Ravichandran*. 2007. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007 450:430-4. 
  • Policarpio-Nicolas ML, Le BH, Mandell JW, Lopes MB*. Granular cell tumor of the neurohypophysis: Report of a case with intraoperative cytologic diagnosis. Diagn Cytopathol. 2008 36:58-63.  
  • Mandell JW*. Immunohistochemical assessment of protein phosphorylation state: the dream and the reality. Histochem Cell Biol. 2008 Sep;130(3):465-71. 
  • Swerdlow RH*, Miller BB, Lopes MB, Mandell JW, Wooten GF, Damgaard P, Manning C, Fowler M, Brashear HR. Autosomal dominant subcortical gliosis presenting as frontotemporal dementia. Neurology. 2009 72:260-7. 
  • Mandell JW*, Locke CN; George Glass G,Gianchandani EP, Bourne TD, Schiff D, Amos S, Papin JA Dephosphorylation of beta-arrestin 1 in glioblastomas. J. Neuropath. Exp. Neurol.  2009 68:535-41. 
  • Glass G, Papin JA, Mandell JW*.  SIMPLE:  A Sequential Immunoperoxidase Labeling and Erasing Method.  J. Histochem. Cytochem. 2009  Volume: 57   Issue: 10   Pages: 899-905.  
  • Heffron DS, Landreth GE, Samuels IS, Mandell JW*. Brain-Specific Deletion Of ERK2 MAP Kinase Leads to Aberrant Cortical Collagen Deposition.  Am. J. Pathol. 2009 Dec;175(6):2586-2599.  
  • Crowley RW, Sansur CA, Sheehan JP, Mandell JW, Kassell NF, Dumont AS*.  Intracranial plasmacytoma with apoplectic presentation and spontaneous intracerebral hemorrhage: Case report and review of the literature. Clin Neurol Neurosurg. 2010 Feb;112(2):172-5.  
  • Daubert EA, Heffron DS, Mandell JW, Condron BG*.  Serotonergic dystrophy induced by excess serotonin. Mol Cell Neurosci. 2010 Jul;44(3):297-306.  
  • Bourne TD, Elias WJ, Lopes MB, Mandell JW*.  WT1 Is Not a Reliable Marker to Distinguish Reactive from Neoplastic Astrocyte Populations in the Central Nervous System. Brain Pathol. 2010 May 30. 
  • Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS, Mandell JW* Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor Brain Behav Immun. 2011 Jul;25(5):915-21.  
  • Sokolowski JD, Mandell JW*.  Phagocytic clearance in neurodegeneration. Am J Pathol. 2011   Apr;178(4):1416-28.  
  •  Louis RG, Yen CP, Mohila CA, Mandell JW, Sheehan J*. A rare intraosseous arteriovenous malformation of the spine. J Neurosurg Spine. 2011 Jun 10. PMID:21663404  
  •  Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS*  ,Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion, Nature, 2013 Apr 24. doi: 10.1038/   
  • Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D, Mandell J, Abounader R.  A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy  Neoplasia. 2013 Aug;15(8):952-65.  
  • Anderson MA, Almira-Suarez MI, Mandell JW, Gaskin CM.  Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings.   American Journal of Skeletal Radiology, Sept. 24, 2013.  Epub ahead of print.  IF=1.54
  • Louis RG, Yen CP, Mohila CA, Mandell JW, Sheehan J*. A rare intraosseous arteriovenous malformation of the spine. J Neurosurg Spine. 2011 Jun 10. PMID:21663404 
  • Hochreiter-Hufford AE, Lee CS, Kinchen JM, Sokolowski JD, Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell JW, Ravichandran KS* ,Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion, Nature, 2013 Apr 24. doi: 10.1038
  • Anderson MA, Almira-Suarez MI, Mandell JW, Gaskin CM. Intraneural perineurioma of the sciatic nerve: an under-recognized nerve neoplasm with characteristic MRI findings.   American Journal of Skeletal Radiology, Sept. 24, 2013. 
  • Williams EA, Chen CJ, Williams B, Shaffrey M, Mandell JW*. Chen CJ, Williams EA, McAneney TE, Williams BJ, Mandell JW, Shaffrey ME. Histiocytic sarcoma of the cavernous sinus: case report and literature review. Brain Tumor Pathol. 2014 May 8. 
  • Sokolowski JD, Heffron DS, LeBlanc A, Deppman C, Mandell JW*. Caspase-mediated cleavage of actin and tubulin is a common feature and sensitive marker of axonal degeneration in neural development and injury. Acta Neuropathol Commun. 2014 Feb 7;2(1):16. doi: 10.1186/2051-5960-2-16.
  • Sokolowski JD, Chabanon-Hicks CN, Han CZ, Heffron DS, Mandell JW.  Fractalkine is a "find-me" signal released by neurons undergoing ethanol-induced apoptosis.
  • Front Cell Neurosci. 2014 Nov 7;8:360. doi: 10.3389/fncel.2014.00360.


A more complete list of Dr. Mandell's publications can be obtained from PubMed