James W. Mandell, M.D., Ph.D.
Professor, Division of
Member, Neuroscience Graduate Program
Associate Director for Curriculum, Medical Scientist Training
Medical School: M.D./Ph.D. Cornell University
Medical College, New York, NY. MD, 1992
Graduate School: Postdoctoral Fellow, Department
of Neuroscience, Laboratory of Dr. Gary Banker, University of Virginia,
1992 - 1994
Residency: Anatomic Pathology, University of Virginia,
1994 - 1996
Fellowship: Fellow, Neuropathology, University of
Virginia, 1996 - 1998
Surgical and Autopsy Diagnostic Neuropathology
In addition to shared coverage of the Diagnostic Surgical and
Autopsy Neuropathology service, I am the sole faculty member
responsible for all neuromuscular biopsy diagnosis as well as for all
ophthalmic pathology diagnosis.
Currently my research program has two funded projects. The
first is focused on discovering and validating biomarkers of synaptic
degeneration, using a global proteomics screening platform. The
second seeks to identify novel biomarkers of inflammatory myopathies,
especially inclusion body myositis, focusing on noncoding RNAs that can
be detected both in muscle biopsies as well as in the circulation.
We have developed a novel multiplex immunhistochemistry platform
(patent application pending) that should have broad utility in anatomic
pathology and seek new collaborative projects.
- Chen CJ, Williams EA, McAneney TE, Williams BJ,
Mandell JW, Shaffrey ME: Histiocytic sarcoma of the
cavernous sinus: case report and literature review. Brain Tumor Pathol
2015, 32:66-71. http://www.ncbi.nlm.nih.gov/pubmed/24807104.
- Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske
JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris
TH, Kipnis J: Structural and functional features of central nervous
system lymphatic vessels. Nature 2015, http://www.ncbi.nlm.nih.gov/pubmed/26030524.
- Sokolowski JD, Gamage KK, Heffron DS, Leblanc AC, Deppmann CD,
Mandell JW: Caspase-mediated cleavage of actin and
tubulin is a common feature and sensitive marker of axonal degeneration
in neural development and injury. Acta Neuropathol Commun 2014, 2:16.
- Nacey NC, Almira Suarez MI, Mandell JW, Anderson
MW, Gaskin CM: Intraneural perineurioma of the sciatic nerve: an
under-recognized nerve neoplasm with characteristic MRI findings.
Skeletal Radiol 2014, 43:375-379. http://www.ncbi.nlm.nih.gov/pubmed/24061494.
- Sokolowski JD, Chabanon-Hicks C, Han CZ, Heffron DS,
Mandell JW: Fractalkine is a "find-me" signal released
by neurons undergoing ethanol-induced apoptosis. Front Cell Neurosci
2014, 8:360. http://www.ncbi.nlm.nih.gov/pubmed/25426022.
- Hochreiter-Hufford A, Lee CS, Kinchen JM, Sokolowski JD,
Arandjelovic S, Call JA, Klibanov AL, Yan Z, Mandell
JW, Ravichandran KS: Phosphatidylserine receptor BAI1 and
apoptotic cells as new promoters of myoblast fusion. Nature 2013,
- Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, Schiff D,
Mandell J, Abounader R: A novel PTEN/mutant
p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of
PTEN with implications for cancer prognosis and therapy. Neoplasia
2013, 15:952-965. http://www.ncbi.nlm.nih.gov/pubmed/23908595.
- Mandell J, Heffron D, Sokolowski J: Persistence Of
Apoptotic Debris In Brain-Specific Rac1-Conditional Knockouts: Evidence
For A Macroglial Clearance Function. JOURNAL OF NEUROPATHOLOGY AND
EXPERIMENTAL NEUROLOGY 2011, 70:528-529. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290751700124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=cfc784e19a5045db07524a7304ce6a05.
- Sokolowski JD, Nobles SL, Heffron DS, Park D, Ravichandran KS,
Mandell JW: Brain-specific angiogenesis inhibitor-1
expression in astrocytes and neurons: implications for its dual
function as an apoptotic engulfment receptor. Brain Behav Immun 2011,
- Louis RG, Yen CP, Mohila CA, Mandell JW,
Sheehan J: A rare intraosseous arteriovenous malformation of the spine.
J Neurosurg Spine 2011, 15:336-339. http://www.ncbi.nlm.nih.gov/pubmed/21663404.
A more complete list of Dr. Mandell's publications
can be obtained from