M. Beatriz S. Lopes, M.D.

Director of Neuropathology and

Neuropathology Fellowship Program

Professor of Pathology

Acting Director of Autopsy

EDUCATION:

MEDICAL SCHOOL: University of Sao Paulo School of Medicine , December 1992, MD

RESIDENCY: Anatomic Pathology, University of Sao Paulo School of Medicine, January 1983 - January 1986

FELLOWSHIP: Neuropathology, University of Sao Paulo School of Medicine, February 1986 - December 1988
Fellowship in Neuropathology, University of Virginia  Health Sciences Center , January 1989 - December 1992

CLINICAL:

Neuropathology, Pituitary Pathology, Autopsy Pathology.

RESEARCH INTERESTS:

My research interests focus on two major areas: 1- Hypothalamic, pituitary and peripheral interactions in the pathogenesis of pituitary adenomas; 2 – Molecular mechanisms of pathogenesis and invasion of brain tumors. My current projects are: 1. Mechanisms of invasion and progression of pituitary adenomas; 2 -Refinement of the morphologic, immunohistochemical and molecular techniques for pathological classification of brain tumors; 3 – The mechanisms of glioma invasion and migration; 4 – The effects of malnutrition and specific micronutrients on intestinal, brain, and cognitive development in a murine model. Experimental techniques in our laboratory include cell culture, immunohistochemistry, immunofluorescence, and in situ hybridization.

REFERENCES:

• Gong J, Zhao Y, Abdel-Fattah R, Amos S, Xiao A, Lopes MBS, Hussaini IM, Laws ERJr. (2008) Matrix metallo¬proteinase-9, a potential biological marker in invasive pituitary adenomas. Pituitary 11: 37-48.
• Policarpio-Nicolas MLC, Le BH, Mandell JW, Lopes MBS (2008) Granular cell tumor of the neurohypophysis:  report of a case with intraoperative cytologic diagnosis. Diagn. Cytopathol. 36: 58-63.
• Mut M, Turba UC, Botella AC, Baskurt E, Lopes MBS, Shaffrey ME (2007) Neuroimaging characteristics in subgroup of GBMs with p53 overexpression. J. Neuroimag. 17: 168-174.
• Pouratian N, Prevedello DM, Jagannathan J, Lopes MBS, Vance ML, Laws ERJr (2007) Outcomes and management of patients with Cushing’s disease without pathological confirmation of tumor resection after transsphenoidal surgery. J. Clin. Endocrinol. Metab. 92: 3383-3388.
• Hussaini IM, Trotter C, Zhao Y, Abdel-Fattah R, Amos S, Xiao A, Agi CU, Redpath GT, Fang Z, Leung GKK, Lopes MBS, Laws ERJr (2007) Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. Am. J. Pathol. 170: 356-365. 
• Bourne TD, Mandell JW, Matsumoto JA, Jane Jr JA, Lopes MBS (2007) Primary disseminated leptomeningeal oligodendroglioma with chromosome 1p deletion. J. Neurosurg (Pediatrics). 105: 465-469. 
• Semple PL, de Villiers JC, Bowen RM, Lopes MBS, Laws ERJr (2006) Pituitary apoplexy: does histology influences the clinical presentation and outcome. J. Neurosurg. 104: 931-937.
• Abdel-Fattah R, Xiao A, Bomgardner D, Pease CS, Lopes MBS, Hussaini I (2006) Differential expression of HOX genes in neoplastic and non-neoplastic human astrocytes. J. Pathol. 209: 15-29. 
• Lopes MBS, Scheithauer BW, Schiff D (2005) Pituitary carcinoma: Diagnosis and Treatment. Endocrine 28: 115-121. 

BOOK CHAPTERS: 

• Lopes MBS, Pernicone PJ, Scheithauer BW, Horvath E, Kovacs K (2007) Pituitary and Sellar Region. In: Histology for Pathologists, 3rd Edition (Mills SE, Ed.), Lippincott Williams & Wilkins, Baltimore, pp. 321-345.
  
• Lopes MBS, VandenBerg SR (2007) Tumors of the Central Nervous System. In: Diagnostic Histopathology of Tumors, 3rd Edition (Fletcher CDM, Ed.). Churchill Livingstone, London, pp. 1653-1732. 
• Lopes MBS (2007) Tumors of the Pituitary Gland. In: Diagnostic Histopathology of Tumors, 3rd Ed (Fletcher CDM, Ed.). Churchill Livingstone, London, pp. 971-996.
• Lopes MBS, Thapar K, Horvath E, Kovacs K. (2006) Neoplasms of the Sellar Region. In: Russell and Rubinstein's Pathology of Tumors of the Nervous System (McLendon RE, Rosenblum MK & Bigner DD, Eds). Hodder Arnold, London, pp. 663-764. 
• Lopes MBS (2005) Neuropathology. In: Principles of Neuro-Oncology (Schiff D, O'Neill B, Eds). McGraw Hill, New York, pp. 81-119. 
• Lopes MBS, Scheithauer BW, Saeger W (2004) Granular Cell Tumor. In: WHO Classification of Tumours, Pathology and Genetic of Tumours of Endocrine Organs.(DeLellis RA, Lloyd RV, Heitz PU, Eng C, Eds.). IARC Press, Lyon, France, pp.44-45. 
• Lopes MBS, Scheithauer BW, Saeger W (2004) Mesenchymal tumours of the pituitary region. In: WHO Classification of Tumours, Pathology and Genetic of Tumours of Endocrine Organs.  (DeLellis RA, Lloyd RV, Heitz PU, Eng C, Eds.). IARC Press, Lyon, France, pp.41-43.

A more complete list of Dr. Lopes' publications can be obtained from PubMed