Doris M. (Dede) Haverstick, Ph.D.

Associate Professor of Pathology

Director of Toxicology, Point of Care Testing

and Specimen Collection and  Management

Associate Director of Clinical Chemistry

Quality and Advisor for the Department of Pathology

EDUCATION:

Graduate Education: St. Louis University  School of Medicine, 1982, Ph.D. in Pharmacology

1983 - 1985: Fellow in Lab Medicine, Washington University

1985 - 1987: Post Doctoral Fellow, Dept. of Biochemistry, University of Illinois

1987 - 1989: Research Associate, Mount Sinai Hospital of Detroit (Center for Cell Biology)

CLINICAL:

• Toxicology: the identification of the agent inducing acute illness and the consequences of environmental pathogens.

• Molecular Diagnostics: use of new techniques in molecular diagnostics, with emphasis on real-time PCR for rapid, definitive diagnosis.

• Management of both financial and personnel resources in the face of changes in health care delivery, including the growth of point of care testing. Specific emphasis on decreasing personnel resources with increasing automation and complexity of tests performed and the impact on quality assurance activities and the need to meet regulatory requirements of multiple agencies (TJC, CAP, CMS, etc.).

RESEARCH:

The cell biology of signal transduction pathways involving changes in intracellular free Ca leading to proliferation (growth). Our model systems include the study of lymphocytes, breast and prostate cancer. Our goal is to understand calcium signaling pathways and use this information to develop new antiproliferative compounds for use in the control of human cancers in a cytostatic manner.

REFERENCES:  

Manuscripts - 

• D.M. Haverstick, L.B. Brill, M.G. Scott, and D.E. Bruns.  Preanalytical variables in measurement of free (Ionized) Calcium in Lithium Heparin-Containing Blood Collection Tubes.  Clin Chim Acta 403:102-104, 2009.
• L.K. Bechtel, D.M. Haverstick, and C.P. Holstege.  Verapamil Toxicity Dysregulates the Phosphatidylinositol 3-Kinase Pathway.  Acad. Emerg. Med. 15:368-374, 2008.
• L.M. Henrich, D.E. Bruns, D.M. Haverstick, V.G. Reynolds, and J.C. Boyd.  Indican interference in Bilirubin assays: A classical solution still applies.  Clin. Chem. 53:359-360, 2007.
• W. F. McCalmont, J. R. Patterson, M. A. Lindenmuth, T. N. Heady, D. M. Haverstick, L. S. Gray, and T. L. Macdonald.  Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists.  Bioorg. Med. Chemistry 13:6821-3839, 2005.
• D. M. Haverstick, G. C. Bullock, and D. E. Bruns.  Genotyping of Hepatitis C virus (HCV) by melting curve analysis: analytical characteristics and performance.  Clin. Chem. 50:2405-2407, 2005.
• P. T. Taylor and D. M. Haverstick.  Re: New Guidelines to Evaluate the Response to Treatment in Solid Tumors (Ovarian Cancer).  (Correspondence) J. Nat. Cancer Inst. 97:151-152, 2005.
• R.F. Louie, M.J. Lau, J. H. Lee, et al.  Multicenter Study on the Prevalence of Blood Contamination on Point-of-Care Glucose Meters and recommendations for controlling contamination. Point of Care 4:158-163, 2005.
• A.H.B. Wu, M. Packer, A. Smith, R. Bijou, D. Fink, J. Mair, L. Wallentin, N. Johnston, C. S. Feldcamp, D. M. Haverstick, C. Ahnardi, A. Grant, N. Despres, B. Bluestein, and F. Ghani.  Analytical and clinical evaluation of the Bayer ADVIA Centaur® automated B-Type Naturiuretic Peptide assay in patients with heart failure: A multisite study.  Clin. Chem. 50:867-873, 2004.
• L.S. Gray, E. Perez-Reyes, J.C. Gamorra, D. M. Haverstick, M. Shattock, L. McLatchie, J. Harper, G. Brooks, T. N. Heady, and T. L. Macdonald.  The role of voltage gated T type Ca2+ channel isoforms in mediating "capacitative" Ca2+ entry in cancer cells. Cell Calcium 36:489-497, 2004.
• D. M. Haverstick.  Critical Value Called - Read Back Obtained. (invited editorial)  Am J. Clin. Path. 121:790-791, 2004.

Book Chapters -

• D.M Haverstick and A. R. Groszbach. Specimen Collection and Processing.  In Fundamentals of Molecular Diagnostics, DE Bruns, ER Ashwood, and CA Burtis, eds.  Elsevier, 2007.
• D.S. Young, E.W. Bermes, and D.M. Haverstick.  Specimen Collection and Other Preanalytical Variables.  In Fundamentals of Clinical Chemistry, CA Burtis, ER Ashwood, and DE Bruns, eds.  Elsevier, 2008.

A more complete list of Dr. Haverstick's publications can be obtained from PubMed.