Henry F. Frierson, Jr., M.D.

Professor of Pathology

EDUCATION:

College: Davidson College , 1977, BS
Medical School: Medical University of South Carolina , 1981, MD
Residency: University of Virginia (AP/CP), 1981-1985

CLINICAL:

General surgical pathology and cytopathology

RESEARCH:

Role of genes and gene products in prostate and salivary cancers; clinical and molecular aspects of adenoid cystic carcinoma; transgenic mouse models of prostate and salivary carcinomas.

REFERENCES:

• Wu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, Theodorescu D: Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. PNAS 106: 5807-5812, 2009.

• Slack-Davis JK, Hershey ED, Theodorescu D, Frierson HF, Parsons JT: Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Can Ther (in press)

• Galgano MT, Conaway M, Spencer AM, Paschal BM, Frierson HF Jr: PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma. Hum Pathol (in press)

• Iizuka M, Takahashi Y, Mizzen CA, Cook RG, Fujita M, Allis CD, Frierson HF Jr, Fukusato T, Smith MM: Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. Gene 436: 108-114, 2009.

• Cathro HP, Loya T, Dominguez F, Howe SL, Howell R, Orndorff K, Moreno J, Mendez E, Fung PC, Beer NL, Allen P, Sosa AM, Gurka KK, Stoler MH, Frierson HF Jr: Human papillomavirus profile of women in Belize City, Belize: correlation with cervical cytopathologic findings. Hum Pathol 40: 942-949, 2009.

• Smith SC, Nicholson B, Nitz M, Frierson HF Jr, Smolkin M, Hampton G, El-Rifai W, Theodorescu D: Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination. Am J Pathol 174:371-379, 2009.

• Schwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson HF Jr, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D: Integrin agonists as adjuvants in chemotherapy for melanoma. Clin Cancer Res 14: 6193-6197, 2008.

• Kanner WA, Saleh KJ, Frierson HF Jr: Reassessment of the usefulness of frozen section analysis for hip and knee joint revisions. Am J Clin Pathol 130: 363-368, 2008.

• Guled M, Myllykangas S, Frierson HF Jr, Mills SE, Knuutila S, Stelow EB: Array comparative genomic hybridization analysis of olfactory neuroblastoma. Mod Pathol 21: 770-778, 2008.

• Marozkina NV, Stiefel SM, Frierson HF Jr, Parsons SJ: MMTV-EGF receptor transgene promotes preneoplastic conversion of multiple steroid hormone-responsive tissues. J Cell Biochem 103: 2010-2018, 2008.

• Wu Y, McRoberts K, Berr SS, Frierson HF Jr, Conaway M, Theodorescu D: Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia. Oncogene 26: 765-773, 2007.

• Frierson HF Jr, Galgano MT: Frozen-section diagnosis by wireless telepathology and ultra portable computer: utility in pathology/resident faculty consultation. Hum Pathol 38: 1330-1334, 2007.Yu Y, Baras AS, Shirasuna K, Frierson HF Jr, Moskaluk CA: Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays. Lab Invest. 2007;87: 430-439.

• Deeble PD, Cox ME, Frierson HF Jr, Sikes RA, Palmer JB, Davidson RJ, Casarez EV, Amorino GP, Parsons SJ: Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. Cancer Res. 2007;67: 3663-3672.

• Meinhold-Heerlein I, Bauerschlag D, Zhou Y, Sapinoso LM, Ching K, Frierson HF Jr, Brautigan K, Sehouli J, Stickeler E, Konsgen D, Hilpert F, von Kaisenberg CS, Pfisterer J, Bauknecht T, Jonat W, Arnold N, Hampton GM: An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma. Clin Cancer Res. 2007;13: 458-466.

• Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF: Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol. 2006;7: 230-240.

• Hong SM, Presley AE, Stelow EB, Frierson HF Jr, Moskaluk CA: Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinoma. Am J Surg Pathol. 2006;30: 744-749.

• Smith SC, Oxford G, Wu Z, Nitz MD, Conaway M, Frierson HF, Hampton G, Theodoresu D: The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer. Cancer Res. 2006;66: 1917-1922.

A current list of Dr. Frierson's journal publications can be obtained from PubMed.