Robin A. Felder, Ph.D.

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Robin A. Felder, Ph.D.

Robin A. Felder, Ph.D. Faculty Profile

RobinFeldermicroscope.jpg

Robin A. Felder, Ph.D.

Professor and Associate Director of

Clinical Chemistry and Toxicology

 

EDUCATION:

Graduate School: Georgetown University, Washington, D.C., PhD, Biochemistry

Post Doctoral Training: The National Institutes of Health (NIH), Bethesda, Maryland


CLINICAL: 

Clinical chemistry; application of automation, robotics, and process improvement to clinical laboratory testing.

BASIC RESEARCH:

Pathogenesis of essential hypertension and salt sensitivity - We employ a multidimensional approach to the study of high blood pressure including the  molecular genetics,  biochemical techniques, in-vitro, and in-vivo studies in humans.    Through the use of in vivo pharmacologic experiments we have demonstrated that a defect in an intracellular enzyme results in the inability to normally excrete sodium, thus leading to elevated blood pressure. Our studies extend to  the use of human subjects in the Clinical Research Center to determine the effect of pharmacologic intervention in normal and pathologic states.

APPLIED RESEARCH:

Medical automation, robotics and process improvement to assist in efficient management of the clinical laboratory.  For a complete list of automation articles visit http://marc.med.virginia.edu.  Dr. Felder has developed a number of medical process improvement technologies and commercialized them through the UVA Patent Foundation process at UVA.   

See also:    

http://medicalautomation.org



  REFERENCES:

  • Jones JE, Armando I, Palmes-Saloma CP, Yu P, Pascua AM, Keever L, ;Francis B,  Arnaldom FB, Wang A, Luo Y, Felder RA, Jose PA. GRK4 regulates the phosphorylation and function of the dopamine D3 receptor in human proximal tubule cells.  JBC, in press 2009.

  • Gildea J, Wang Xiaoli, Jose PA, Felder RA. Differential D1 and D5 receptor regulation and degradation of the angiotensin type 1 receptor. Hypertension. 2008 Feb;51(2):360-6. PMID: 8172057

  • Wang Z, Armando I, Asico L, Escano C, Wang X, Lu Q, Felder RA, Schnackenberg C, Sibley DR, Eisner Gilbert, Jose PA. The elevated blood pressure of human GRK4γ A142V transgenic mice is not associated with increased ROS production. AJP: Heart and Circulatory Physiology: Manuscript Number: H-00944-2006.R1 (in press)

  • Salomone LJ, Howell NL, McGrath HE, Kemp BA, Keller SR, Gildea JJ, Felder RA, Carey RM. Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism. Hypertension. 2007 Jan;49(1):155-61.

  • Sanada H, Yatabe J, Midorikawa S, Katoh T, Shigeatsu H, Watanabe T, Xu J, Felder RA, Jose PA. Amelioration of genetic hypertension by post-translational suppression of GRK4 in the kidney. Hypertension. 2006 Jun;47(6):1131-9.

  • Yu P-Y, Asico LD, Eisner GM, Hopfer U, Felder RA, Jose PA. Increased serine-phosphorylation of the D1 receptor in renal proximal tubule cells in spontaneous hypertension. Kidney Int. 2006 Sep;70(6):1072-9. Epub 2006 Jul 19.

  • Zeng CY, Wang Z, Yang ZW, He DF, Yang CM, Asico LD, Felder RA, Jose PA. [G protein kinase 4gammaA142V overexpression induced hypertension by downregulating D1 receptors in transgenic mice] Zhonghua Xin Xue Guan Bing Za Zhi. 2006 May;34(5):411-4. Chinese.

  • Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH, Ritchie MD, Williams SM, Pezzullo JC, Sasaki M, Eisner GM, Jose PA, Felder RA. Diagnosis of Salt Sensitive Hypertension Using Single Nucleotide Polymorphisms. Clin Chem. 52(3):352-60, March 2006.

  • Zeng CY, Yang ZW, Wu LJ, Asico LD, Felder RA, Jose PA. [Hypertension in D3 dopamine receptor deficient mice] Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1132-6. Chinese.

  • Zeng C, Wang Z, Hopfer U, Asico LD, Eisner GM, Felder RA, Jose PA. Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalized renal proximal tubule cells. Hypertens 46(4):799-805, October 2005.

  • Zeng C, Hopfer U, Asico LD, Eisner GM, Felder RA, Jose PA. Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats. Hypertens. 46(4):926-931, October 2005.

  • Zeng C, Wang Z, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Kidney Int 68(2):623-631, August 2005.

  • Yoneda M, Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Sasaki M, Katoh T, Watanabe T, Andrews PM, Jose PA, Felder RA. Differential effects of angiotensin II type-1 receptor antisense oligonucleotides on renal function in spontaneously hypertensive rats. Hypertens 46(1):58-65, July 2005.

  • Jose PA, Eisner GM, Felder RA. Regulation of blood pressure by dopamine receptors. Nephron Physiol 95(2):19-27, 2003.

  • Bengra C, Mifflin TE, Khripin Y, Manunta P, Williams SM, Jose PA, Felder RA. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. Clin Chem 48(12):2131-2140, December 2002.

  • Watanabe H, Xu J, Bengra C, Jose PA, Felder RA. Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4. Kidney Int 62(3):790-798, September 2002.

  • Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown NJ, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 99(6):3872-3877, March 2002.


PATENTS:

  • System and Process for Non-Invasive Collection and Analysis of Physiologic Signals, #7,396,331, Issued 07-08-08

  • System and Method for Passive Monitoring of Blood Pressure and Pulse Rate, #0173363-A1, Issued 08-03-2006

  • Automated Storage and Retrieval Apparatus for Freezers #6,941,762, Issued 09-13- 2005

  • G Protein-Related Kinase #6,660,474, Issued 12-09-2003

  • Automated Storage/Retrieval Apparatus for Freezers #6,581,395, Issued 09-24-2003

  • Automated Storage/Retrieval Apparatus for Freezers #6,688,123, Issued 05-05-2003.

  • Automated Robotic Pickup and Delivery System #6,543,983, Issued 04-08-2003

  • Automated Storage/Retrieval Apparatus for Freezers #6,467,285, Issued 10-22-2002

  • Interactive Remote Sample Analysis System #6192320, Issued 02-20-2001

  • Interactive Remote Sample Analysis System #6055487, Issued 04-25-1999

  • Interactive Remote Sample Analysis System #5631844, Issued 05-20-1997

  • Robotically Operated Laboratory System #5366896, Issued 11-22-1994


BOOKS:

  • Zhang M, Nelson B, Felder RA. (Eds.). Life Science Automation: Fundamentals and Applications, Artech House, Inc., Norwood, MA, USA, 2007. ISBN-13; 978-1-59693-105-3

  • Alwan M, Felder RA (Eds.).  Eldercare Technology for Clinical Practitioners, Humana Press, Totowa, NJ, USA,, 2008. ISBN 978-1-58829-898-0

  • Felder RA,  Alwan MA, Zhang M, (Eds.). Systems Engineering Approach to Medical Automation, Artech House, Inc., Norwood, MA, USA, 2008. ISBN-13; 978-1-59693-164-0

A more complete list of Dr. Felder's publications can be obtained from Pubmed.