David E. Bruns, M.D.

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David E. Bruns, M.D.

David E. Bruns, M.D. Faculty Profile


David E. Bruns, M.D.

Professor of Pathology

Director of Clinical Chemistry

Associate Director of Molecular Diagnostics

Co-Director, Fellowship in Clinical Chemistry and Laboratory Medicine


Medical School: St. Louis University, MD, 1973

Residency and Fellowship: Departments of Pathology and Internal Medicine, Washington University, 1973-1977


Clinical chemistry and molecular diagnostics.


  • Quality requirements for medical tests

  • Harmonization of laboratory tests



  • Bruns DE, Ashwood ER, Burtis CA, eds. Fundamentals of Molecular Diagnostics. St. Louis: Saunders/Elsevier, 2007.

  • Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th ed., St. Louis: Saunders/Elsevier, 2012.

  • Burtis CA, Bruns DE, eds. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. 7th ed. St. Louis: Saunders/Elsevier, 2015



  • Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG,      Moher D, Rennie D, DeVet HC. Towards complete and accurate reporting of studies of      diagnostic accuracy: The STARD Initiative. Ann Intern Med 2003; 138:40-44 (and 14 other journals).
  • Sacks, DB, Arnold A, Bakris GL, Bruns DE, Horvath AR, Kirkman SK ,  Lernmark A, Metzger BE , Nathan DM. Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2011;57:793-8 and Diabetes Care 2011;34:1419-23.
  • Sacks DB, Bruns DE, Horton J, Lindberg S, Mahoney JJ, Manzella S, Reilly ET, Scott MG. Point-of-care blood glucose testing in acute and chronic care facilities: approved guideline. Clinical Laboratory Standards Institute 2013;33:1-48.
  • Algeciras-Schimnich A, Bruns DE, Boyd JC, Bryant S, La Fortune KA, Grebe SKG. Failure of current laboratory protocols to detect lot-to-lot reagent differences: Findings and possible solutions. Clin Chem 2013;59:1187-94. (Related Editorial: Bennett ST. Clin Chem 2013;59:1145-7).
  • Kelly BN, Haverstick DM, Lee JK, Thorner MO, Vance ML, Xin W, Bruns DE. Circulating microRNA as a biomarker of human growth hormone administration to patients. Drug Test Anal 2014;6:234-8. 
  • Mitsios JV, Ashby LA, Haverstick DM, Bruns DE, Scott MG. Analytic evaluation of a new glucose meter system in 15 different critical care settings. Diabetes Sci Technol 2013;7:1282-7.
  • Bachmann LM, Nilsson G, Bruns DE, McQueen MJ, Lieske JC, Zakowski JJ, Miller WG. State of the art for measurement of urine albumin: comparison of routine measurement procedures to isotope dilution tandem mass spectrometry. Clin Chem 2014;60:471-80. (Related Editorial: Scott MG, Coyne DW. Clin Chem 2014;60:435-7.)
  • Boyd JC, Bruns DE. Effects of measurement frequency on analytical quality required for glucose measurements in ICUs: assessments by simulation models. Clin Chem 2014;60:644-50. (Related Editorial: Van den Berghe G. Clin Chem 2014;60:577-9).



  • Bruns DE. Optimal Glucose Monitoring. 31st International Symposium on Intensive Care and Emergency Medicine. Brussels, March 22-25, 2011.Bruns DE. Are glucose meters up to the task of TGC? 2011 Arnold O. Beckman Conference. San Diego, April 12-13, 2011.

  • Bruns DE, Boyd JC. POCT Glucose measurement and its limitations. 21st International Congress of Clinical Chemistry and Laboratory Medicine. Berlin, May 15-20, 2011.

  •  Bruns DE. Accuracy requirements for glucose assays used to support intensive insulin therapy. Diabetes Diagnostics. Zwolle, The Netherlands, September 20, 2011.

  • Bruns DE. Glucose Measurements in Critical Care. 32nd International Symposium on Intensive Care and Emergency Medicine. Brussels, March 22-23, 2012.

  • Bruns DE. Labomas. Endocrine Grand Rounds, University of Virginia School of Medicine. October 16, 2012.

  • Bruns DE. Directions in Clinical Chemistry and Laboratory Medicine. Opening Plenary Lecture. IFCC General Conference. Kuala Lumpur, Malaysia. November 17-20, 2012.

  • Bruns DE. Desirable performance for point-of-care glucose measurements in hospital settings. EUROMEDLAB Milano. 20th IFCC-EFCC European Congress of Laboratory Medicine. 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology. Milan, Italy. May 19-23, 2013.

  • Bruns DE.  Hemoglobin A1c as a Diagnostic Tool - Requirements. Latin-American Congress of Clinical Biochemistry. Lima, Peru.  October 29-31, 2013.

  • Bruns DE. Desirable analytical performance of continuous glucose monitors. IFCC WORLDLAB Congress, International Federation of Clinical Chemistry. Istanbul, June 22-26, 2014.


    A current list of Dr. Bruns' peer-reviewed publications is available from PubMed.