Professor of Pathology

Director of Clinical Chemistry and Toxicology

• Evidence-based laboratory medicine

• Assessment of diagnostic accuracy of clinical tests

• Editor, Clinical Chemistry, 1990 – 2007; Perspectives Editor, 2008 - present: Clinical Chemistry (Online Edition): www.clinchem.org

• President, Association of Clinical Scientists, 1986

• President, Academy of Clinical Laboratory Physicians and Scientists, 2005-2006

• Board of Directors, American Association for Clinical Chemistry, 2009-2011

• Clinical Staff Executive Committee, University of Virginia Health System 2009-2011 

• Burtis CA, Ashwood EA, Bruns DE, eds. Tietz Fundamentals of Clinical Chemistry. 6th ed. St. Louis: Saunders/Elsevier, 2008.    

• Bruns DE, Ashwood ER, Burtis CA, eds. Fundamentals of Molecular Diagnostics. St. Louis: Saunders/Elsevier, 2007.

• Burtis CA, Ashwood ER, Bruns DE, eds., Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 4th ed., St. Louis: Saunders/Elsevier, 2006.

• Bruns DE, Knowler WC. Stabilization of glucose in blood samples: Why it matters. Clin Chem [Editorial] 2009;55 (In press).

• Haverstick DM, Brill LB, Scott MG, Bruns DE. Preanalytical variables in measurement of free (ionized) calcium in lithium heparin-containing blood collection tubes. Clin Chim Acta 2009 (In press).

• Miller WG, Bruns DE. Laboratory issues in measuring and reporting urine albumin. [Editorial] Nephrol Dial Transplant 2009;24:717-8.

• Miller WG, Narva A, Bruns DE, Hortin GL, Sandberg S, Aakre ML, Jones G, McQueen MJ, Seccome DW, Itoh Y, Bunk DM, Lieske JC, Curhan GC. Current issues in measurement and reporting of urinary albumin excretion. Clin Chem 2009;55:24-38.

• Scott MG, Bruns DE, Boyd JC, Sacks DB. Tight glucose control in the intensive care unit: Are glucose meters up to the task? [Perspective] Clin Chem 2009;55:18-20.

• Scott MG, Bruns DE, Sacks DB. Tight glucose control in critically ill adults [Letter]. JAMA 2008; 300(23):2726-7.

• Bruns DE. Improving training in laboratory medicine. Clin Chim Acta 2008;393:3-4.

• Rifai N, Bossuyt PMM, Bruns DE. Identifying Duplicate Publications: Primum non Nocere. Clin Chem 2008;54:777-8.

• Bruns DE. Are meters accurate enough? Diabetes Forecast 2008;61:18

• Mikesh LM, Crowe SE, Bullock GC, Taylor NE, Bruns DE. Celiac disease refractory to a gluten-free diet? Clin Chem 2008;54:441-4.

• Henrich LM, Bruns DE, Haverstick DM, Reynolds V, Boyd JC. Indican interference in bilirubin assays: a classical solution still applies. Clin Chem 2007;53:359-361.

• Henrich LM, Rogol AD, D'Amour P, Levine MA, Hanks JB, Bruns DE. Persistent hypercalcemia after parathyroidectomy in an adolescent and effect of treatment with cinacalcet HCl. Clin Chem 2006;52:2286-93.

• Oosterhuis WP, Bruns DE, Watine J, Sandberg S, Horvath AR. Recommendations for evidence-based guidelines in laboratory medicine. Clin Chem 2004;50:806-18.

• Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis C, Glasziou P, Irwig L, Moher D, et al. Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative. Explanation and elaboration. Ann Intern Med 2003;138:W1-W12. Clin Chem 2003;49:7-18.

• Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis C, Glasziou P, Irwig L, Lijmer JG, et al. The STARD Initiative: Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy. Acad Radiol 2003;10:664-9. AJR Am J Roengenol 2003;181:51-5. Ann Clin Biochem 2003;40(pt 4):357-63. Ann Intern Med 2003;138:40-44. Am J Clin Pathol 2003;119:18-22. BMJ 2003;326:41-44. Clin Biochem 2003;36:1-7. Clin Chem 2003;49:1-6. Clin Chem Lab Med 2003;41:68-73. Ned Tijdschr Geneeskd 2003;147:336-40 (Dutch). Radiology 2003;226:24-8.

• Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002;48:436-72 and Diabetes Care 2002;25:750-86.

• Parrish D, Bruns DE. US legal principles and confidentiality of the peer review process, JAMA 2002;5;287:2839-41

• Bullock, GC, Bruns DE, Haverstick DM. Hepatitis C genotype determination by melting cuve analysis with a single set of fluorescence resonance energy transfer probes. Clin Chem 2002; 48:2147-54

• Price CP, Bossuyt PMM, Bruns DE, Introduction to Clinical Chemistry and Evidence-Based Laboratory Medicine. Chapter 1 In Burtis CA, Ashwood ER, Bruns DE, eds. Fundamentals of Clinical Chemistry. St.Louis: Suanders/Elsevier, 2008.   

• Bruns DE, Price CP, Bossuyt PMM. Introduction to Evidence-Based Molecular Diagnostics. In Bruns DE, Ashwood ER, Burtis C, eds. Fundamentals of Molecular Diagnostics. St. Louis: Saunders/Elsevier, 2007.

• Chute D, Bruns DE.  Metabloic Acidosis of Unknown Origin Among Burn Patients.  In Scott MG, Gronowski AM, Eby CS. Tietz Applied Laboratory Medicine. Philadelphia: Lippincott Williams & Wilkins. 2007.

• Presley AE, Bruns DE. A Happy but Developmentally Delayed 5-Year-Old Boy.  Ibid 2007.

• Henrich LM, Rogol AD, Bruns DE. A 10-Year Old Boy with Pain-Induced Seizures.  Ibid 2007.

• Bruns DE, Bennett.  A 9-Year-Old Boy with Skin Lesions and Headaches. ibid. 2007.     

• Use of Methodological Standards in Studies of Diagnostic Accuracy: Getting Better but Still Not Good 10 Years after Reid, Lachs and Feinstein.  Academy of Clinical Laboratory Physicians and Scientists.  Denver, June 4, 2004.   

• Laboratory-related Outcomes in Healthcare.  Tenth Asian-Pacific Congress of Clinical Biochemistry. Perth, Australia.  September 22, 2004.

• Summarise the Evidence.  Workshop on Evidence-based Medicine. Freematle, Western Australia.  September 24, 2004.

• Methodological Standards in Studies of Diagnostic Accuracy: Getting Better, But Still Not Good.  Greek Society of Clinical Chemistry.  Athens, November 18, 2004.

• Effects of analytical imprecision and bias on patient care.  Mayo Foundation Symposium.  Orlando, Florida.  July 23, 2005.

• Interferences Matter.  Australasian Association of Clinical Biochemists.  Sydney, Australia. October 6, 2005.

• The STARD Initiative.  Department of Pathology, Brigham and Womens Hospital and Harvard University.  April 20, 2006.

• Excellence in Patient-Centered Laboratory Medicine: Challenges for Academia, Industry and Government. University of Cape Town. South Africa. June 26, 2006.

• Views of Clinical Chemistry from the Journal Clinical Chemistry. Universities of Stellenbosch and Pretoria, South Africa. June 29, 2006.

• Excellence in Patient-Centered Laboratory Medicine: Challenges for Academia, Industry and Government. Medical University of South Africa. June 30, 2006.

• Views of Clinical Chemistry from the Journal Clinical Chemistry. South African Association of Clinical Biochemists. Durban, South Africa. July 3, 2006.

• Excellence in Patient-Centered Laboratory Medicine: Challenges for Academia, Industry and Government. 46th Conference of the Federation of South African Societies of Pathology.  Durban, South Africa.  July 4, 2006.

• Do We Need Journals Anymore? Athena Society Triennial Meeting. Mykonos, Greece.  September 6, 2006.

• Assessment of the Accuracy of Diagnostic Tests. Symposium on Scientific Principles and Clinical Practice in Assessment of Diagnostic Tests.  Seoul, South Korea, September 4, 2007.

• Do We Know the Diagnostic Accuracy of the Tests We Perform? Macgregor Lecture, Department of Pathology, University of Alberta, Edmonton, Alberta, Canada, October 4, 2007.

• Improving Training in Laboratory Medicine.  Keynote Lecture. International Conference on Laboratory Medicine. Padua, Italy, October 23, 2007.

• How Accurate are Glucose Meters - How Accurate Do They Need to Be - Are New Meters Substantially Better?  American Diabetes Association.  San Francisco, June 8, 2008.

• Laboratory measurement of urine albumin. American Association for Clinical Chemistry Annual Meeting, Washington, DC, July 31, 2008.

• Adding Value in Laboratory Medicine. Keynote Address. V Argentine Congress of Quality in Clinical Laboratories, CALILAB 2008. Buenos Aires, Argentina, September 10, 2008.

• Diabetes and prediabetes: Laboratory update and new diagnostic perspectives. IFCC International Congress, Fortaleza, Brazil, October 1, 2008.

• How Accurate are Glucose Meters - How Accurate Do They Need to Be - Are New Meters Substantially Better?  Best of ADA – India. Calcutta, November, 2008