Thomas J. Braciale, M.D., Ph.D.

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Thomas J. Braciale, M.D., Ph.D.

Thomas J. Braciale, M.D., Ph.D. Faculty Profile

 
 
 
Braciale

Thomas J. Braciale, M.D., Ph.D.

Director, Beirne Carter Center for Immunology Research

Professor of Pathology and Microbiology


EDUCATION:

Graduate School: University of Pennsylvania, Philadelphia, PA, PhD, Microbiology, 1974  

Medical School: University of Pennsylvania School of Medicine, Philadelphia, PA, MD, 1975

Graduate Medical Education: Intern/Resident in Pathology, Washington University School of Medicine, St. Louis, MO, 1975-76

Postdoctoral: Visiting Fellow, Australian National University, John Curtin School of Medical Research, Canberra, Australia, 1976-78

 

 RESEARCH:

Our research on Influenza focuses on the response of CD8+ T lymphocytes -- Cytolytic T Lymphocytes (CTL) or killer T cells -- to Influenza infection. We want to understand three main things: 1) how CTL are generated during infection; 2) how CD8+ T cells interact with the principal antigen presenting cells of the body (i.e. dendritic cells) to produce those CTL; and 3) how the interplay between Influenza virus and the CTL response contributes to lung injury during infection. We use modern techniques of cell and molecular biology -- including T cell receptor transgenic murine models and virus reverse genetics (to alter the structure of the Influenza genome) in order to understand how specific virus genes (and their products), as well as CTL products (e.g. cytokines) operate to clear infection and/or produce disease. Recently, we have extended this work to include avian influenza virus ("Bird Flu") infection in order to define the mechanisms of lethal infection produced by this virus.
 

REFERENCES:

Kim T.S., Gorski, S.A., Hahn, S., Murphy, K., and Braciale, TJ, Distinct Dendritic Cell Subsets dictate the Fate Decision Between Effector and
 Memory CD8+ T Cell Differentiation: A Contribution of CD24. 2014, Immunity (In press)
· Gorski SA, Hahn, YS, Braciale TJ. Group 2 innate lymphoid cell production of IL5 is regulated by NKT cells during influenza virus infection. PLoS
 Pathogen 2013 Sep; 9(9):e1003615. doi: 10.1371/journal.ppat.1003615. Epub 2013 Sep 19. PMID: 24068930 PMCID: PMC3777868
· Yoo J, Fish E, Braciale TJ. LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection. J
 Exp Med. 2012 Sep 24; 209(10):1853-67. PMID: 22987801 PMCID: PMC3457726
· Sun J, Dodd H, Moser EK, Sharma R and Braciale TJ: CD4+ T cell help and innate-derived IL-27 induce Blimp-1 dependent IL-10 production by
 anti-viral CTL. Nature Immun. 2011 Feb 6 PMID: 21297642 PMCID: PMC3079402

A more complete list of Dr. Braciale's publications can be obtained from PubMed