Thomas J. Braciale, M.D., Ph.D.
Thomas J. Braciale, M.D., Ph.D. Faculty Profile
Thomas J. Braciale, M.D., Ph.D.
Director, Beirne Carter Center for
Professor of Pathology and
School: University of Pennsylvania, Philadelphia, PA, PhD,
School: University of Pennsylvania School of Medicine,
Philadelphia, PA, MD, 1975
Medical Education: Intern/Resident in Pathology, Washington
University School of Medicine, St. Louis, MO, 1975-76
Postdoctoral: Visiting Fellow, Australian National
University, John Curtin School of Medical Research, Canberra,
Our research on Influenza focuses on the response of CD8+ T lymphocytes
-- Cytolytic T Lymphocytes (CTL) or killer T cells -- to Influenza
infection. We want to understand three main things: 1) how CTL are
generated during infection; 2) how CD8+ T cells interact with the
principal antigen presenting cells of the body (i.e. dendritic cells)
to produce those CTL; and 3) how the interplay between Influenza virus
and the CTL response contributes to lung injury during infection. We
use modern techniques of cell and molecular biology -- including T cell
receptor transgenic murine models and virus reverse genetics (to alter
the structure of the Influenza genome) in order to understand how
specific virus genes (and their products), as well as CTL products
(e.g. cytokines) operate to clear infection and/or produce disease.
Recently, we have extended this work to include avian influenza virus
("Bird Flu") infection in order to define the mechanisms of lethal
infection produced by this virus.
- Hufford MM, Kim TS, Sun J, Braciale TJ: The
effector T cell response to influenza infection. Curr Top Microbiol
Immunol 2015, 386:423-455. http://www.ncbi.nlm.nih.gov/pubmed/25033753.
- Steinke JW, Liu L, Turner RB, Braciale TJ, Borish
L: Immune surveillance by rhinovirus-specific circulating CD4+ and CD8+
T lymphocytes. PLoS One 2015, 10:e0115271. http://www.ncbi.nlm.nih.gov/pubmed/25584821.
- Krueger PD, Kim TS, Sung SS, Braciale TJ, Hahn YS:
Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in
situ. J Immunol 2015, 194:3213-3222. http://www.ncbi.nlm.nih.gov/pubmed/25712214.
- Yao S, Jiang L, Moser EK, Jewett LB, Wright J, Du J, Zhou B, Davis
SD, Krupp NL, Braciale TJ, Sun J: Control of
pathogenic effector T-cell activities in situ by PD-L1 expression on
respiratory inflammatory dendritic cells during respiratory syncytial
virus infection. Mucosal Immunol 2015, 8:746-759. http://www.ncbi.nlm.nih.gov/pubmed/25465101.
- Braciale T, Kim T: Influenza pathogenesis: club
cells take the "cure". J Exp Med 2014, 211:1705. http://www.ncbi.nlm.nih.gov/pubmed/25155720.
- Buckley MW, Arandjelovic S, Trampont PC, Kim TS, Braciale
TJ, Ravichandran KS: Unexpected phenotype of mice lacking
Shcbp1, a protein induced during T cell proliferation. PLoS One 2014,
- Dolina JS, Braciale TJ, Hahn YS:
Liver-primed CD8+ T cells suppress antiviral adaptive immunity through
galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of
high-mobility group box 1 in mice. Hepatology 2014, 59:1351-1365. http://www.ncbi.nlm.nih.gov/pubmed/24677194.
- Kim TS, Gorski SA, Hahn S, Murphy KM, Braciale TJ:
Distinct dendritic cell subsets dictate the fate decision between
effector and memory CD8(+) T cell differentiation by a CD24-dependent
mechanism. Immunity 2014, 40:400-413. http://www.ncbi.nlm.nih.gov/pubmed/24631155.
- Moser EK, Hufford MM, Braciale TJ: Late engagement
of CD86 after influenza virus clearance promotes recovery in a FoxP3+
regulatory T cell dependent manner. PLoS Pathog 2014, 10:e1004315. http://www.ncbi.nlm.nih.gov/pubmed/25144228.
- Yoo JK, Braciale TJ: IL-21 promotes late activator
APC-mediated T follicular helper cell differentiation in experimental
pulmonary virus infection. PLoS One 2014, 9:e105872. http://www.ncbi.nlm.nih.gov/pubmed/25251568.
- Yoo JK, Kim TS, Hufford MM, Braciale TJ: Viral
infection of the lung: host response and sequelae. J Allergy Clin
Immunol 2013, 132:1263-1276. http://www.ncbi.nlm.nih.gov/pubmed/23915713.
A more complete list of
Dr. Braciale's publications can be obtained from