Thomas J. Braciale, M.D., Ph.D.

Director, Beirne Carter Center for Immunology Research

Professor of Pathology and Microbiology

 

CONTACT INFORMATION:

Telephone: (434) 924-9233

Email: tjb2r@Virginia.EDU

EDUCATION:

Graduate School: University of Pennsylvania, Philadelphia, PA, PhD, Microbiology, 1974  

Medical School: University of Pennsylvania School of Medicine, Philadelphia, PA, MD, 1975

Graduate Medical Education: Intern/Resident in Pathology, Washington University School of Medicine, St. Louis, MO, 1975-76

Postdoctoral: Visiting Fellow, Australian National University, John Curtin School of Medical Research, Canberra, Australia, 1976-78

 

 RESEARCH:

My laboratory is interested in the function of CDS+ T lymphocytes specifically their mechanism of action in clearing infection and producing injury. We have developed a transgenic model of T cell mediated lung injury and are studying the mechanisms by which CD8⁺ cytotoxic T cells produce different patterns of lung injury. This model appears to have many features of certain human lung disease with an autoimmune etiopathogenesis including interstitial pulmonary fibrosis, sarcoid and lymphocytic interstitial pneumonia.

REFERENCES:

• Yoon HS, Legge KL, Sung-sang JS, Braciale TJ. Sequential activation of CD8+ T cells in the draining lymph nodes in response to pulmonary virus infection.  (In Press.)  J Immunol, 2007.

• Ison MG, Gubareva L, Braciale TJ. Comparative anti-Influenza activity of Oseltamivir and ABT-677 in immuno-deficient SCID mice.  J Infectious Dis., 193: 765-772. 2006.

• Galkina E, Thatte  J, Dabak D,  Williams MB, Ley K, Braciale TJ.  Preferential migration of activated effector CD8+ T-cells into the interstitium of the normal lungs.  J Clin Inv, 115: 3473-3483. 2005.

• Legge KL, Braciale TJ. Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.  Immunity, 23: 649-659. 2005.

• Lawrence CW, Braciale TJ. Activation, differentiation and migration of naïve, virus-specific CD8+ T cells during pulmonary Influenza virus infection. J Immunol, 173:1209-1218. 2004.

• Legge KL, Braciale TJ.  Accelerated Migration of Respiratory Dendritic Cells to the Regional Lymph Nodes is Limited to the Early Phase of Pulmonary Infection. Immunity, 18: 265-277. 2003.

A more complete list of Dr. Braciale's publications can be obtained from PubMed