Orthopaedic Research

Orthopaedic Research

 

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The Department of Orthopaedic Surgery at the University of Virginia is among the national leaders in clinical, translational, and basic science research.  We are commited to contributing to the continuing evolution of our collective understanding of musculoskeletal anatomy, physiology, biomechanics, and pathology through research and scholarship.  Our faculty are experts in their respective fields holding leadership positions in several national and international Orthopaedic socieities, serving as chief editors for numerous leading Orthopaedic journals and textbooks, lecturing and presenting U.Va. reseach on the podium at national and international meetings, and participating as Visiting Professors for other Orthopaedic departments across the country.  Our faculty have published hundreds of peer-reviewed journal articles, textbooks, and chapters.  We are proud of our commitment to research and our contributions to science of Orthopaedic Surgery.

Individual research interests by division are listed below.

Adult Reconstruction Division

Thomas E. Brown, MD Associate Professor of Orthopaedic Surgery. Involved in clinical research concerning primary and revision hip and knee arthroplasty.

James A. Browne, MD Assistant Professor of Orthopaedic Surgery; Medical Director of the Orthopaedic Outpatient Clinics.  Research interests include clinical outcomes, quality, and safety following hip and knee replacement. Ongoing projects include investigating failed metal-on-metal hip implants and the impact of obesity on postoperative complications. He has been involved in clinical trials of implants and the investigation of novel surgical techniques in joint replacement.  He had presented his research internationally and has published many peer-reviewed manuscripts.  He was recently honored with the Knee Society John Insall Award for a clinical research study looking at complications and resource consumption following knee repalcement in morbidly obese patients.

Quanjun Cui, MD Associate Professor of Orthopaedic Surgery; Medical Director, 6-East, Orthopaedics and Trauma. Area of expertise: hip and knee replacement, femoroacetabular impingement (FAI), osteonecrosis, navigation and minimal invasive surgery. Research interests include (1) outcomes of total joint replacement surgery, (2) stem cell and gene therapy for musculoskeletal diseases including osteonecrosis and fractures, (3) development of novel composite bone graft substitutes, and (4) pathogenesis and treatment of osteonecrosis of the femoral head. Dr. Cui's research is currently supported by National Institute of Health (NIH) and Department of Defense (DOD).

Foot and Ankle Division

Joseph Park, MD Assistant Professor of Orthopaedic Surgery; Dr. Park is active in clinical/translational research and biomechanical studies involving tendon transfers, Achilles tendinopathy, ankle instability, peroneal tendon subluxation.  We are currently enrolling patients in prospective studies looking into these disorders. 

M. Truitt Cooper, MD Assistant Professor of Orthopaedic Surgery; current research interests include techniques for correction of forefoot deformities, fusion of arthritic joints in the foot and cartilage repair techniques.

Hand and Upper Extremity Division

A. Bobby Chhabra, MD Lillian T. Pratt Distinguished Professor; Chair, Department of Orthopaedic Surgery; Division Head, Hand Surgery.  Area of expertise: hand, wrist, elbow, and peripheral nerve surgery.  Research interests include distal radius fracture fixation, elbow injuries in throwing athletes, and tissue engineering techniques for flexor tendon repair.

Rashard Dacus, MD Assistant Professor of Orthopaedic Surgery. He is currently working on a research project to study the effect of EMG results on treatment plans/outcomes in patients with carpal and cubital tunnel syndrome.

Nicole Deal, MD Assistant Professor of Orthopaedic Surgery.  Research interests include: 1) nerve repair and regeneration; 2) muscle re-innervation using stem cells; 3) tissue engineering for nerve repair.

Aaron Freilich, MD Assistant Professor of Orthopaedic surgery.  Research interests include identifying and tracking patient's clinical outcomes after procedures to improve results in hand and wrist surgery and the use of technology in orthopaedics and education. Dr. Freilich is also interested in the biomechanics of injury and prevention.

Pediatrics Division and Gait Lab

Mark Abel, MD Charles J. Frankel Professor of Orthopaedic Surgery; Vice Chair, Department of Orthopaedic Surgery; Associate Chief Medical Officer for Surgical Services, University of Virginia Medical Center; Medical Director, University of Virginia Motion Analysis and Motor Performance Laboratory; Division Head, Division of Pediatric Orthopaedics.  Dr. Abel's research interest include:1) optimizing the outcome of Spinal surgery in children and adolescents;2) assessing and managing musculoskeletal deformity and movement impairments for children with cerebral palsy; 3) improving quality and safety in Operating Room environment

Mark J. Romness, MD Associate Professor of Orthopaedic Surgery, Division of Pediatric Orthopaedic Surgery; Secondary App't in Pediatrics. He has focused on th treatment of children with musculoskeletal problems and the effectiveness of those treatments.  Children with cerebral palsy and related disorders represent a sub-specialized area of interest in his career. Areas within cerebral palsy include gait and functional mobility, treatment for spasticity and contractures and bracing.  Pediatric fractures as well as foot and ankle problems are also areas of special interest.

Spine Division

Francis Shen, MD Warren G. Stamp Professor of Orthopaedic Surgery, Division Head Spine Surgery, Director Spine Fellowship, Co-Director Spine Center. Involved with research involving improved fusion capacity following spinal decompression and instrumentation, spine surgery, spine fusion and mesenchymal cell based bone grafts for spine fusion. The purpose of his research is to develop a bone graft substitute that places osteogenic precursors, in the form of multipotential adipose-derived stromal cells, within bioabsorbable osteoconductive microspheres combined with an osteoinductive growth factor.

Adam Shimer, MD Assistant Professor of Orthopaedic Surgery. Treatment using gene therapy for intervertebral disc degeneration. 

Sports Medicine Division

Stephen Brockmeier, MD  Assistant Professor of Orthopaedic Surgery; Team Physician University of Virginia Athletics; Associate Team Physician, James Madison University Athletics; Dr. Brockmeier has ongoing basic science and clinical research in a number of areas primarily involving the shoulder and knee. Areas of interest include techniques for the management of biceps tendon pathology, biologic and structural augmentation of rotator cuff repair, management of shoulder instability in the contact or overhead athlete, and advancement in the techniques and outcomes of conventional/reverse total shoulder arthroplasty. He was awarded a UVa Research and Development grant for a cadaveric biomechanical investigation of a novel technique for tenodesis of the long head biceps tendon. He is currently the Principle Investigator for two funded studies, one evaluating stemless total shoulder arthroplasty and one investigating augmentation of rotator cuff repair. He served as Deputy Editor for the Journal of Bone and Joint Surgery Sports Medicine Highlights, serves on the Editorial board for two subspecialty journals, and has presented research and been education faculty at a number of national meetings including AAOS and AOSSM. He has authored numerous peer-reviewed articles, book chapters, and review articles in the areas of sports medicine and shoulder reconstruction.

Eric W. Carson, MD Associate Professor of Orthopaedic Surgery; Research interests include osteochondral injuries, ligament grafts, shoulder instability, articular cartilage matrix degradation, biomechanics, anatomy, physiology and cartilage research.

David Diduch, MD A. R. Shands Professor of Orthopaedic Surgery; Head Orthopaedic Team Physician University of Virginia Athletics; Director, Sports Medicine Fellowship Program. Shoulder and knee surgery. Dr. Diduch is very active in translational and clinical research, with over 20 projects currently ongoing in his division.  Areas of interest include: 1. articular cartilage repair for damaged knee cartilage; 2. osteochondral plug transfers for bone and cartilage defects in the knee in high level athletes; 3. hyaluronic acid (HA) injections for knee pain involving the kneecap, also called patellofemoral pain; 4. a novel implantable spring device for the knee to unload arthritic joints; 5. development and studying new devices and methods to fix or tenodese the biceps tendon in the shoulder for SLAP tears and biceps tendon problems; 6. improved techniques in ACL reconstruction, meniscal repair, and rotator cuff repair; 7. emerging understanding of how to evaluate and treat a sports hernia

F. Winston Gwathmey, MD Assistant Professor of Orthopaedic Surgery; Associate Team Physican University of Virginia Athletics, Associate Team Physician James Madison University Athletics; Dr. Gwathmey is an editor for the prestigious Journal of Bone and Joint Surgery. and has edited numerous textbooks including DeLee and Drez's Principles of Sports Medicine.  He has authored numerous book chapters and peer-reviewed articles and has presented research at national meetings including the American Academy of Orthopaedic Surgery and the Arthroscopy Association of North America.  Research interests include: 1) Femoroacetabular impingement and the mechanics and pathomechanics of the hip joint; 2) ACL injury; 3) Multiple ligament knee injuries and knee dislocation; 4) Shoulder instability. 

Mark Miller, MD S. Ward Casscells Professor of Orthopaedic Surgery, responsible for OITE review and Basic Science research in sports medicine and hamstring regeneration research. (Shoulder, Knee, Anatomy, Physiology).  Dr. Miller has done extensive research in the areas of knee meniscal repair, anterior and posterior cruciate ligament reconstruction, shoulder labral and rotator cuff injuries, and a variety of other areas.  He has published over 150 peer-reviewed papers in prestigious journals including The Journal of Bone and Joint Surgery (where he now serves as the Deputy Editor for Sports Medicine) and The American Journal of Sports Medicine (where he is a member of the Editorial Board).  His research in Anterior Cruciate Ligament reconstruction has received national attention, and he leads the group at UVA that is completing ground-breaking research in this area.  Largely as a result of his research, Dr. Miller has been recognized as a "Top 19 National Sports Medicine Surgeon" by Orthopaedics Weekly.

Joseph Hart, PhD Assistant Professor of Orthopaedic Surgery.  Patients who opt for reconstruction after anterior cruciate ligament injury often want to remain active. Unfortunately, these patients often experience early-onset osteoarthritis.  My research focus, which builds from my student experience and my research in patient-oriented outcomes, aims to help patients with major knee injuries or surgery achieve their goals and lead a healthy lifestyle.  Central to this research is identification modifiable neuromuscular factors that may expose patients to risk during activity and exercise, the development of translational therapies and rehabilitation strategies, and intervening in these patients early and often after major knee joint injuries. 

Trauma Division

David M. Kahler, MD Professor of Orthopaedic Surgery. Special interest in trauma surgery, shoulder surgery, and computer assisted surgery. His research centers around development of new techniques and workflows in image guided surgery and validation of existing techniques. Current work emphasizes expansion of existing techniques for pelvic fractures toward use in routine long-bone fracture care, and causes of failure in lateral locked plating of femoral fractures.

David Weiss, MD Associate Professor of Orthopaedic Surgery; Head of the Division of  Orthopaedic Trauma.  Areas of expertise: Severe trauma to pelvis and acetabulum (hip socket), fractures involving joints and bones of the hip, knee, thigh, leg, ankle and foot.  Research interests: Serves as the primary investigator at UVA for several multi center clinical trials involving METRC (multiple extremity trauma research consortium) which investigate the functional recovery and burden of severe orthopaedic injuries.  Also works with the UVA Center for Applied Biomechanics on blast injury research in relation to military vehicles. 

Basic Science

Xudong (Joshua) Li, MD, PhD Assistant Professor of Orthopaedic Surgery. His research interests is in the restoration of a functional disc by an ex vivo approach using transplanted ADAS cells that are transduced with Ad-GDF-5 into the annulus of an injured disc. This research on GDF-5 engineered ADAS cells and the in vivo characterization of the disc could lead to a novel approach for the treatment of late stage disc injury or degeneration, and, if successful data from this project will support the effort to achieve disc repair in humans.

Gary Balian, PhD Professor of Orthopaedics and Professor of Biochemistry and Molecular Genetics, Director of Orthopaedic Research Laboratories, and Director of T32 Musculoskeletal Research Training Program. Dr. Balian is an internationally recognized cell biologist. He is responsible for coordinating the overall schedule for the basic science lecture series and oversees the residents involved in laboratory research. He is also responsible for instruction in biochemical aspects of orthopaedics. His research interests involve prostate cancer cell-bone marrow adhesion mediators. The contribution of this research to our understanding of cancer cell homing to bone may be forthcoming from the identification of molecular targets in bone. Bone repair is clearly a very important area of consideration in the field of musculoskeletal tissue regeneration. Inclusion of bone targeting factors in synthetic or natural polymers potentiate repair through mechanisms that are well characterized biologically at the cellular and molecular levels. Two unique bone targeting peptides potentiate the differentiation of mesenchymal cells in vitro, moreover, the peptides promote bone repair in critical sized unicortical defects. The potential anabolic effects of these novel peptides on bone density and gene expression is under investigation.