Dr Li Publications

Dr Li Publications

1. Liu Q, Jin L, Shen FH, Balian G, Li X. Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells-A novel treatment for intervertebral disc degeneration. Spine J. 2013 May 10

2. Yang XL, Shang HL, Katz A, Li X. GDF-5 mediated chondrogeneiss in microsphere culture. BioResearch Open Access, In press.

3. Liu Q, Jin L, Mahon BH, Chordia MD, Shen FH, Li X. A novel treatment of neuroinflammation against low back pain by soluble Fullerol nanoparticles. Spine, 2013 March 5

4. Jin L, Shimer AL, Li X. The Challenge and Advancement of Annulus Fibrosus Tissue Engineering. Eur Spine J. 2013 May;22(5):1090-100

5. Jin L, Li X. Growth and Differentiation Factor 5 in Bone Regeneration. Current Pharmacology Design. Curr Pharm Des. 2013;19(19):3364-73

6. Shen FH, Werner BC, Liang H, Shang H, Yang N, Li X, Shimer AL, Balian G, Katz AJ. Implications of adipose-derived stromal cells in a 3D culture system for osteogenic differentiation: an in vitro and in vivo investigation. Spine J. 2013 Jan;13(1)32-43

7. Jin L, Feng G, Reames DL, Li X. The effect of simulated microgravity on intervertebral disc degeneration. Spine J. 2013 Mar;13(3):235-42

8. Zhang D, Jin L, Shen FH, Li X. The effect of ApoE on intervertebral disc. Journal of Orthopaedic Research, J Orthop Res. 2013 Feb;31(2):210-7

9. Jin L, Wan Y, Shen FH, Li X. Intervertebral Disc-Like Biphasic Scaffold – DBM Cylinder and PPCLM – for Interbody Spine Fusion. Journal of Tissue Engineering. 2012;3(1):2041731412454420

10. Kapur SK, Wang X, Shang H, Yun S, Li X, Feng G, Khurgel M, Katz AJ. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids. Biofabrication 4, 2012

11. Liu HJ, Yang XL, Zhang Yi, Dighe A, Li X, Cui Q. Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. Journal of Orthopaedic Research, 30(7):1051-7; 2012

12. Yang XL, Wang DD, Hao JR, Gong MQ, Arlet V, Balian G, Shen FH, Li X. Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture. Tissue Engineering Part A, 2011 Jun;17(11-12):1595-603

13. Liang H, Wang K, Shimer AL, Li X, Balian G, Shen FH. Use of a bioactive scaffold for the repair of bone defects in a novel reproducible vertebral body defect model. Bone. 2010, 47(2):197-204

14. Yang X, Wan Y, Qiao X, Arlet V, Li X. Transcriptional alteration of matrix-related gene expression in cultured human disc cells by nanoparticles of a bis-methanophosphonate fullerene. Cell Biol Int. 2010 1;34(8):837-44.

15. Deng M, Nair LS, Nukavarapu SP, Jiang T, Kanner WA, Li X, Kumbar SG, Weikel AL, Krogman NR, Allcock HR, Laurencin CT. Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering. Biomaterials. 2010, 31(18):4898-90

16. Gong M, Zhang D, Wan Y, Edmondson B, Cui Q, Li X. Engineered Synovial Joint Condyle using Demineralized Bone Matrix. Material Science and Engineering C, 2010, 30(531-536)

17. Feng G, Yang X, Shang H, Ian Marks, Shen FH, Katz A, Arlet V, Laurencin CT, Li X. Multipotential differentiation of human annulus fibrosus cells - an in vitro study. Journal of Bone and Joint Surgery, Journal of Bone and Joint Surgery, 2010, 92(3):675-85

18. Liang H, Shen-Ying Ma, Feng G, Shen FH, Li X. In vivo study of adenovirus-mediated gene transfer of Growth and Differentiation Factor-5 to treat disc degeneration induced by annulus needle-puncture. Spine Journal, 2010, 10(1):32-41. 2009 Outstanding Paper Runner up

19. Yang X, Li X. Nucleus pulposus tissue engineering: state of the art. European Spine Journal. 2009, 18(11):1564-72.

20. Yang P, Wang C, Shi Z, Huang X, Dang X, Li X, Lin S-F, Wang K. rhVEGF165 Delivered in a Porous β-Tricalcium Phosphate Scaffold Accelerate Bridging of Critical-Sized Defects in Rabbit Radii. Journal of Biomedical Materials Research: Part A, 2010, 92(2):626-40

21. Feng G, Wan Y, Shen FH, Li X. Nucleus Pulposus Explant Culture Model. Journal of Orthopaedic Research, 2009, 27(6):814-9.

22. Feng G, Wan Y, Balian G, Laurencin CT, Li X. Adenovirus-Mediated Expression of Growth and Differentiation Factor-5 Promotes Chondrogenesis of Adipose Stem Cells. Growth Factors. 2008, 26(3):132-42

23. Wan Y, Feng G, Shen FH, Laurencin CT, Li X. Biphasic Scaffold for Annulus Fibrosus Tissue Regeneration. Biomaterials. 2008, 29(6):643-52.

24. Cui M, Wan Y, Anderson DG, Shen FH, Leo BM, Laurencin CT, Balian G, Li X. GDF-5 Protein and DNA Therapy Potentiates Intervertebral Disc Cell Aggregation and Chondrogenic Gene Expression. Spine Journal, 2008, 8(2):287-95. (Outstanding Paper Award)

25. Wan Y, Feng G, Shen FH, Balian G, Laurencin CT, Li X. Novel Biodegradable Poly (1, 8-diol malate (POM) for Annulus Fibrosus Regeneration. Macromolecular Bioscience.2007, 7(11):1217-24.

26. Zeng Q, Li X, Choi L, Beck G. Balian G, Shen FH. Stimulation of osteogenic differentiation in fat-derived stromal cells in vitro using recombinant growth and differentiation factor-5 (GDF-5) and BMP-2 with different regulatory mechanisms. Bone. 2007, 40(2):374-381

27. Zeng Q, Li X, Choi L, Beck G. Balian G, Shen FH. Recombinant growth/differentiation factor-5 (GDF-5) stimulates osteogenic differentiation of fat-derived stromal cells in vitro. Connective Tissue Research, 2006, 47(5):264-70

28. Shen FH, Zeng Q, Lv Q, Choi L, Balian G. Li X, Laurencin CT. Osteogenic differentiation of adipose-derived stromal cells treated with GDF-5 cultured on a novel three-dimensional sintered microsphere matrix. Spine Journal, 2006, 6(6):615-23 (Outstanding Paper Award)

29. Cui Q, Xiao Z, Li X, Saleh K, Balian G. Use of genetically engineered bone-marrow stem cells to treat femoral defects: an experimental study. Journal of Bone and Joint Surgery, 2006, 88(Suppl 3):167-72

30. Li X, Jin L, Balian G, Laurencin CT, Anderson DG. Demineralized Bone Matrix Gelatin as Scaffold for Osteochondral Tissue Engineering. Biomaterials, 2006, 27(11):2426-33

31. Li X, Lee JP, Balian G, Anderson DG. Modulation of Chondrocytic Properties of Fat-derived Mesenchymal Cells in co-cultures with Nucleus Pulposus. Connective Tissue Research, 2005, 42 (2):1-6

32. Anderson DG, Li X, Balian G. A Fibronectin Fragment Alters the Metabolism by Intervertebral Disc Cells in vitro. Spine, 2005, 30(11):1242-1246

33. Kofron MD, Li X, Laurencin CT. Protein and gene-based tissue engineering in bone repair. Current Opinion in Biotechnology, 2004, 15(5):399-405

34. Li X, Jin L, Cui Q, Wang G-J, Balian G: Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporosis International, 2004, 16: 101-108

35. Li X, Leo BM, Beck G, Balian G, Anderson DG. Collagen and proteoglycan abnormalities in GDF-5 deficient mice may be corrected by treating disc cells with recombinant growth factor. Spine, 2004, 29(20):2229-2234

36. Leo BM, Li X, Balian G, Anderson DG. In vivo bioluminescent imaging of virus mediated gene transfer and transduced cell transplantation in the intervertebral disc. Spine, 2004, 29(8): 838-844

37. Li X, Cui Q, Wang GJ, Balian G: Lovastatin Inhibits Adipogenic and Stimulates Osteogenic Differentiation by Suppressing PPAR2 and Increasing Cbfa1/Runx2 Expression in Bone Marrow Mesenchymal Cell Culture. Bone, 2003, 33(4): 652-659

38. Anderson DG, Li X, Tannoury T, Beck G, Balian G: A Fibronectin Fragment Stimulates Intervertebral Disc Degeneration in vivo. Spine, 2003, 28(20): 2338-2345