Translational Research

Translational Research

Fibrocytes in the Pathogenesis of Sickle Cell Lung Disease

Principle Investigator: C. Edward Rose, Jr., MD

The pulmonary sequela of sickle cell anemia includes chronic interstitial lung disease and secondary pulmonary hypertension and fibrosis.  This project  assesses the role of circulating fibrocytes in the pathogenesis of sickle cell lung injury.

Support: National Institutes of Health:  1R01HL098526-01

Fibrocytes in Human Pulmonary Fibrosis

Co-Principle Investigators: Borna Mehrad, MD and C. Edward Rose, Jr., MD

To date no therapy exists for idiopathic pulmonary fibrosis (IPF) which significantly prolongs life expectancy.  This project will evaluate the role of circulating fibrocytes in the pathogenesis of IPF.   In addition, clinical trial of the mTOR (fibrocytle) inhibitor sirolimus on circulating fibrocyte numbers and phenotype is under way.

Support: National Institutes of Health:  1R01HL098239-01

Mechanisms and Consequences of Sleep-disordered Breathing in Chronic Obstructive Pulmonary Disease

Principle Investigator: Cynthia Brown, MD

The primary goal of this mentored career-development award is increased understanding of the mechanisms and consequences of sleep-disordered breathing in chronic obstructive pulmonary disease.

Support: National Institutes of Health 5K23HL098563

Circulating Progenitor Cells in Severe Asthma

Principle Investigator: C. Edward Rose, Jr, MD

This project will evaluate circulating fibrocyte numbers and phenotype as biomarkers for severe fixed obstructive asthma both in cross-sectional and longitudinal studies in patients with severe asthma.

Support: Novartis Institutes for Biomedical Research, Inc.