George M. Verghese, MD

 

George M. Verghese, MD

Verghese, George

 

 

 

 

 

 

 

George M. Verghese, MD
Rank/Position:

Associate Professor of Medicine
Medical Director, Medical Intensive Care Unit
Medical Director, Interstitial Lung Disease Clinic
Fellowship: University of California San Francisco
Office Address: P.O. Box 800546

Division of Pulmonary and Critical Care Medicine
University of Virginia Health System
Charlottesville, VA 22908
Phone: 434-243-4845
FAX: 434-924-9682
Board Certifications: Internal Medicine
Pulmonary Disease
Critical Care Medicine
Email: gmv4n@virginia.edu
Clinics: UVA Interstitial Lung Disease Clinic: 434-924-5219

UVA Fishersville Satellite Pulmonary Clinic:  540-332-5870
Clinical Practice: Interstitial lung disease,  general pulmonary, lung cancer, critical care.
Research Interests: Interstitial lung disease, lung cancer, clinical trials.

Publications (selected):

Verghese, GM, Gutknecht, MF, and Caughey, GH.  Prostasin Regulates Epithelial Monolayer Function: Cell-specific Gpld1-dependent secretion and Functional Significance of the GPI Anchor.  Am. J. Physiol. Cell Physiol. 291:C1258-70, 2006.

Zaman, K, Carraro, S, Doherty, J, Henderson, EM, Liu, L, Lendermon, E, Verghese, G, Zigler, M, Ross, M, Park, E, Palmer, LA, Doctor, A, Stamler, JS, and Gaston, B.  S-nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells.  Mol. Pharmacol. 70:1435-42, 2006.

Tong, Z, Illek, B, Bhagwandin, VJ, Verghese, GM, and Caughey, GH.  Prostasin, a Membrane-anchored Serine Peptidase, Regulates Sodium Currents in Cystic Fibrosis Airway Epithelia.  Am. J. Physiol. Lung Cell. Mol. Physiol. 287:L928-35, 2004.

Verghese, GM, Tong, ZYT, Bhagwandin, VJ, and Caughey, GH.  Mouse Prostasin Gene Structure, Promoter Analysis, and Restricted Expression in Lung and Kidney.  Am. J. Resp. Cell Mol. Biol. 30:519-29, 2004.

Caughey, GH, Raymond, WW, Blount, JL, Hau, LWT, and Verghese, GM.  Characterization of Human g-Tryptases, Novel Members of the Chromosome16p Mast Cell Human Tryptase and Prostasin Gene Families.  J. Immunol. 164:6566-75, 2000.

 



Pugin, J., Verghese, GM, Widmer, M-C, and Matthay, MA.  The Alveolar Space is the Site of Intense Inflammatory and Profibrotic Reactions in the Early Phase of ARDS.  Crit. Care Med. 27: 304-312, 1999.

Verghese, GM, Ware, LB, Matthay, BA, and Matthay, MA.  Alveolar Epithelial Fluid Transport and the Resolution of Severe Hydrostatic Pulmonary Edema.  J. App. Physiol. 87: 1301-12, 1999.

Verghese, GM, McKormick-Shannon, K, Mason, RJ, and Matthay, MA.  Hepatocyte Growth Factor and Keratinocyte Growth Factor in the Pulmonary Edema Fluid of Patients with Acute Lung Injury.  Am. J. Respir. Crit. Care Med. 158: 386-394, 1998.

Cabell, CH, Verghese, GM, Rankl, NB, Burns, DJ, and Blackshear, PJ.  MARCKS Phosphorylation by Individual Protein Kinase C Isozymes in Insect Sf9 Cells.  Proc. Assoc. Am. Physicians 108: 37-46, 1995.

 

 

 

 

Verghese, GM, Johnson, JD, Vasulka, C, Haupt, DM, Stumpo, DJ, and Blackshear, PJ.  Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein.  J. Biol. Chem. 269: 9361-9367, 1994.



Blackshear, PJ, Verghese, GM, Johnson, JD, Haupt, DM and Stumpo, DJ.  Characteristics of the F52 protein, a MARCKS homologue.  J. Biol. Chem. 267: 13450-13456, 1992.