C. Edward Rose, Jr, MD

C. Edward Rose, Jr, MD

Rose, Edward








C. Edward Rose, Jr, MD


Division Chief
Dudley F. Rochester Professor of Medicine
Fellowship Program Director

Fellowship: University of Alabama in Birmingham (1977-1979)
University of Colorado (research) (1979-1979)
Office Address: P.O. Box 800546

Division of Pulmonary and Critical Care Medicine
University of Virginia Health System
Charlottesville, VA 22908

Phone: 434-243-4845
FAX: 434-924-9682
Board Certifications: Internal Medicine
Pulmonary Disease
Critical Care Medicine
Clinics: UVA Pulmonary Clinic:  434-924-5219
Clinical Practice: General pulmonary, asthma and non-asthmatic COPD, sarcoidosis, venous thromboembolic disorders.
Research Interests: Role of chemokines and fibrocytes in inflammatory lung disorders.

Publications (selected):

Field JJ, Burdick MD, Debaun MR, Strieter BA, Liu L, Mehrad B, Rose CE Jr, Linden J, Strieter RM.  The role of fibrocytes in sickle cell lung disease. PLoS One. 2012;7(3):e33702. Epub 2012 Mar 19.

Rose, C. E., Jr., Lannigan, J. A., Kim, P., Lee, J. J., Fu, S. M., Sung, S. S.:  Murine eosinophil activation and chemokine products in allergic airway inflammation.  Cellular and Molecular Immunology 7:361-374, 2010.

Behm, C.Z., Kaufmann, B.A., Carr, C., Lankford, M., Sanders, J.M., Rose, C.E., Jr., Kaul, S., Lindner, J.R.:  Molecular imaging of endothelial VCAM-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis.  Circulation 117:2902-2911, 2008.

Li, L., Huang, L., Sung, S.-S.J., Vergis, A., Rose, C.E., Jr., Lobo, P.I., Okusa, M.D.:  Phenotypically distinct macrophages contribute to renal ischemia-reperfusion injury through CCR2- and CX3CR1-medicated recruitment.  Kidney Int.  74:1526-1537, 2008.

Beaty, S.R., Rose, C.E., Jr., Sung, S.-S.J.:  Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation.  J. Immunol.  178:1882-1895, 2007.

Sung, S.-S., Fu, S.M., Rose, C.E., Jr.,  Gaskin, F., Ju, S.-T.; Beaty, S.R.:  A major lung CD103(aE)-Beta7  integrin-positive epithelial dendritic cell population expressing langerin and tight junction proteins.  J. Immunol.  176:2161-2172, 2006.

Basit, A., Reutershan, J., Morris, M.A., Solga, M., Huang, L., Rose, C.E., Jr., Ley, K.:  ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into alveolar space.  Am. J. Physiol. 291:L200-L207, 2006.

Grinnan, D., Sung, S.-S., Doughtery, J.A., Knowles, A.R., Allen, M.B., Rose, C.E. III, Nakano, H., Gunn, M.D.,  Fu, S.M., Rose, C.E., Jr.:  Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice.  JACI 118:1234-1241, 2006.

Rose, C.E., Sung, S.J., Fu, S.M.:  Significant involvement of CCR2 in inflammatory disorders of the lung. In:  Chemokines.  Ley, K. (ed.),  Microcirculation 10:273-288, 2003.

Schrenengost, J.E., LeGallo, R.D., Boyd, J.D., Moons, K.G.M., Gonias, S.L., Rose, C.E., Jr., Bruns, D.E.:  Comparison of diagnostic accuracies in outpatients and hospitalized patients of d-dimer testing for the detection of suspected pulmonary embolism. Clin. Chem.  49:1483-1490, 2003.

Forlow, S.B., Rose, C.E., Ley, K.:  Leukocyte adhesion and emigration in the lung.  In:  Interactions of Blood and the Pulmonary Circulation.  Weir, E.K., Reeve, H.L., Reeves, J.T. (eds.).  Armonk, N.Y.:  Futura Publishing Company, Inc., 2002.

Sung, S.J., Rose, C.E., Jr., Fu, S.M.:  Intratracheal priming with ovalbumin- and ovalbumin 323-339 peptide-pulsed dendritic cells induces airway hyperresponsiveness,  lung eosinophilia, goblet cell hyperplasia, and inflammation.  J. Immunol. 166:1261-1271, 2001.

Kim, Y.-B.,  Sung, S., Kuziel, W.A., Feldman, S.F., Fu, S.M., Rose, C.E., Jr.:  Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).  J. Immunol. 166:5183-5192, 2001.

Kamochi, M., Kamochi, F., Kim, Y.B., Sawh, S., Sanders, J.M., Sarembock, I., Green, S., Young, J.S., Ley, K., Fu, S.M., and Rose, C.E., Jr. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am. J. Physiol.   277:L310-L319, 1999.

Gupta, S., Feng, L., Yoshimura, T., Redick, J., Fu, S.M., Rose, C.E.:  Intra-alveolar MIP-2 induces rapid neutrophil localization in the lung.  Am. J. Respir. Cell Mol. Biol 15:656-663, 1996.

Rose, C. E., Juliano, C. A., Tracey, D. E., Yoshimura, T., Fu, S. M.:  Role of interleukin-1 in endotoxin-induced lung injury in the rat.   Am. J. Respir. Cell Mol. Biol.   10:214-221, 1994.

Peach, M. J., Johns, R. A., Rose, C. E., Jr.:  The potential role of interactions between endothelium and smooth muscle in pulmonary vascular physiology and pathophysiology. In: Pulmonary Vascular Physiology and Pathophysiology. Ed. by E. K. Weir and J. T. Reeves, Marcell Dekker, Inc.:  New York, 1989, pp. 643‑697.

Brashers, V. L., Peach, M. J., Rose, C. E., Jr.:  Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation.  J. Clin. Invest.  82:1495-1502, 1988.

Rose, C. E., Jr., Dixon, B. S., Anderson, R. J.:  Effects of hypoxemia  and hypercapnic acidosis in renal water excretion and vasopressin secretion.  In:  Vasopressin. Ed. by R. W. Schrier, Raven Press:  New York, 1985, pp. 517‑524.

Carey, R. M., Stote, R. M., Dubb, J. W., Townsend, L. H., Rose, C. E., Jr., Kaiser, D. L.:  Effect of selective peripheral dopamine‑1(DA‑1) receptor stimulation in human essential hypertension. J. Clin. Invest.  74:2198‑2207, 1984.