Borna Mehrad, MBBS

Borna Mehrad, MBBS

Mehrad - 2012

 

 

 

 

 

 

 

Borna Mehrad, MBBS

Rank/Position:

Professor of Medicine
Associate Division Chief for Research
Director, Interstitial Lung Disease Program
Course Director, Clinical Conference
Course Director, Research Conference

Fellowship: University of Michigan
Office Address: P.O. Box 800546

Division of Pulmonary and Critical Care Medicine
University of Virginia Health System
Charlottesville, VA 22908

Phone: 434-243-4845
FAX: 434-924-9682
Board Certifications: Internal Medicine
Pulmonary Disease
Critical Care Medicine
Email: bm6fx@virginia.edu
Clinics: UVA Interstitial Lung Disease Clinic:   434-924-5219
Clinical Practice: Interstitial lung diseases, pulmonary infections including opportunistic lung infections, general pulmonary.
Research Interests: Lung inflammation, antimicrobial host defense.

Publications (selected):

 

Camnitz W, Burdick MD, Strieter RM, et al. Dose-dependent effect of statin therapy on circulating CXCL12 levels in patients with hyperlipidemia. Clin Transl Med 1:23, 2013.

Keeley EC, Mehrad B, Kramer CM. Response to Van Koppen et al. J Hypertens 31:1054-1055, 2013.

Barletta KE, Ley K, Mehrad B. Regulation of neutrophil function by adenosine. Arterioscler Thromb Vasc Biol 32:856-864, 2012.

Keeley EC, Mehrad B, Strieter RM. Fibrocyte differentiation pathways. In: Fibrocytes in health and disease.  Bucala R (ed). World Scientific Publication Co, Hackensack: 45-52, 2012.

Mehrad B, Keeley EC, Kolb M, Strieter RM. Fibrocytes in interstitial lung disease. In: Fibrocytes in health and disease. Bucala R (ed). World Scientific Publication Co, Hackensack: 131-142, 2012.

Keeley EC, Mehrad B, Strieter RM. ELR+ CXC chemokines and their role in malignancy. In: The inflammatory milieu of tumors: cytokines and chemokines that affect tumor growth and metastases. Ben-Baruch A (ed). Bentham Science. 79-85, 2012.

Barletta KE, Cagnina RE, Wallace KL, Ramos SI, Mehrad B, Linden J. Leukocyte compartments in the mouse lung: distinguishing between marginated, interstitial, and alveolar cells in response to injury. J Immunol Methods. 2012; 375(1-2):100-10.

Barletta KE, Ley K, Mehrad B. Regulation of neutrophil function by adenosine. Arterioscler Thromb Vasc Biol. 2012; 32(4):856-64.

Field JJ, Burdick MD, DeBaun MR, Strieter BA, Liu L, Mehrad B, Rose CE, Linden J, Strieter RM. The Role of fibrocytes in sickle cell lung disease. PloS ONE. 2012; 7(3): e33702.

Park SJ, Burdick MD, Mehrad B. Neutrophils mediate maturation and efflux of lung dendritic cells in response to Aspergillus germ tubes. Infect Immun. 2012; 80(5):1759-65.

Mehrad B, Strieter RM. Fibrocytes and the Pathogenesis of diffuse parenchymal lung disease. Fibrogenesis Tissue Repair. 2012; 5(suppl 1):S22.

Keeley EC, Janardhanan R, Salerno M, Hunter JR, Burdick MM, Mehrad B, Kramer CM. Elevated circulating fibrocyte levels in subjects with hypertensive heart disease. J Hypertension, 2012: in press.

Keeley EC, Mehrad B, Strieter RM. CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res.  2010;106:91-111.

Keeley EC, Mehrad B, Strieter RM. Fibrocytes: Bringing new insights into mechanisms of inflammation and fibrosis. Int J Biochem Cell Biol. 2010;42:535-42.

Park SJ, Burdick MD, Brix WK, Stoler MH, Askew DS, Strieter RM, Mehrad B. Neutropenia enhances lung dendritic cell recruitment in response to an opportunistic mold via a cytokine-to-chemokine positive feedback loop. J Immunol. 2010;185:6190-6197.

Keeley EC, Mehrad B, Strieter RM. CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res.  2010;106:91-111.

Keeley EC, Mehrad B, Strieter RM. Fibrocytes: Bringing new insights into mechanisms of inflammation and fibrosis. Int J Biochem Cell Biol. 2010;42:535-42.

Park SJ, Burdick MD, Brix WK, Stoler MH, Askew DS, Strieter RM, Mehrad B. Neutropenia enhances lung dendritic cell recruitment in response to an opportunistic mold via a cytokine-to-chemokine positive feedback loop. J Immunol. 2010;185:6190-6197.

Crawford MA, Zhu Y, Green CS, Burdick MD, Sanz P, Alem F, O’Brien AD, Mehrad B, Strieter RM, Hughes MA. 2009. Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli. Infect Immun 77(4):1664-78.

Park SJ, Hughes MA, Burdick MD, Strieter RM, Mehrad B. 2009. Early NK cell-derived interferon gamma is essential to host defense in neutropenic invasive aspergillosis. J Immunol 182(7):4306-12.

Keeley EC, Mehrad B, Strieter RM. 2009. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders. Thromb Haemost 101(4):613-8.

Strieter RM, Keeley EC, Burdick MD, Mehrad B. The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis. Trans Am Clin Climatol Assoc 2009;120:49-59.

Strieter RM, Keeley EC, Hughes MA, Burdick MD, Mehrad B. The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis. J Leukoc Biol 2009;86:1111-8.

Mehrad B, Burdick MD, Strieter RM. 2009. Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int J Biochem Cell Biol 41(8-9):1708-18.

Park SJ, Mehrad B. Innate immunity to Aspergillus: a state-of-the-art review. Clin Microbiol Rev 2009;22(4):535-51.

Keeley EC, Mehrad B, Strieter RM. 2008. Chemokines as mediators of neovascularization. Arterioscler Thromb Vasc Biol, 28(11):1928-36.

Mehrad B, Burdick MD, Zisman DA, Keane MP, Belperio JA, Strieter RM. 2007. Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease. Biochem Biophys Res Commun. 353(1):104-8.

Mehrad B, Keane MP, Strieter RM. Chemokines as mediators of angiogenesis. 2007. Thromb Haemost 97(5):755-62.

Phadke AP, Akangire G, Park SJ, Lira SA, Mehrad B. 2007. The role of CC chemokine receptor-6 in host defense in murine invasive pulmonary aspergillosis. Am J Respir Crit Care Med. 1;175(11):1165-72.

Mehrad B, Keane MP, Gomperts BN, Strieter RM. 2007. Circulating progenitor cells in chronic lung disease. Expert Rev Respir Med. 1(1):157-165.

Mehrad B, Park SJ, Akangire G, Standiford, TJ, Wu T, Zhu, J, Mohan C. 2006. The lupus susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176: 3233–3239.

Park SJ, Wiekowski MT, Lira SA, Mehrad B. 2006. Neutrophils regulate airway responses in a model of fungal allergic airways disease. J Immunol 176: 2538-2545.

Phadke AP, Mehrad B. 2005. Role of cytokines in innate host defense against Aspergillus: recent advances. Med Mycology 423: S173-S176.

Belperio JA, Keane MP, Burdick MD, Gomperts B, Xue YY, Hong K, Mestas J, Ardehali A, Mehrad B, Saggar R, Lynch JP, Ross DJ, Strieter RM. 2005. Vascular remodeling during the pathogenesis of bronchiolitis obliterans syndrome: the role of CXCR2/CXCR2 ligands. J Clin Invest 115:1150-1162.

Lira SA, Mehrad B, Chen SC, Zalamea P, Kinsley DJ, Wiekowski MT, Coronel E, Vassileva G, Manfra D,  Jensen KK. 2004. Conditional transgenic models to study chemokine biology. Methods Mol Biol 239:105-122.

Vongpatanasin W, Tuncel M, Wang Z, Arbique D, Mehrad B, Jialal I. 2003. Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women. J Am Coll Cardiol 41:1358-1363.

Morrison BE, Park SJ, Mooney JM, Mehrad B. 2003. Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis. J Clin Invest 112:1862-1870.

Mehrad B, Wiekowski M, Morrison BE, Chen SC, Coronel EC, Manfra DJ, Lira SA. 2002. Transient lung specific expression of the chemokine KC improves outcome in invasive aspergillosis. Am J Respir Crit Care Med 166:1263-1268.

Blease K, Mehrad B, Lukacs NW, Kunkel SL, Standiford TJ, Hogaboam CM. 2001. Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Aspergillus fumigatus conidia. J Immunol 166:1832-1842.

Chen SC, Mehrad B, Deng JC, Vassileva G, Manfra DJ, Cook DN, Wiekowski MT, Zlotnik A, Standiford, TJ, Lira SA. 2001. Impaired pulmonary host defense in mice lacking expression of the CXC chemokine lungkine. J Immunol 166:3362-3368.

Mehrad B, Paciocco G, Martinez FJ, Ojo TC, Iannettoni MD, Lynch JP 3rd. 2001. Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature. Chest 119:169-175.

Blease K, Mehrad B, Standiford TJ, Lukacs NW, Gosling J, Boring L, Charo IF, Kunkel SL, Hogaboam CM. 2000. Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- mice. J Immunol 165:2603-2611.

Blease K, Mehrad B, Standiford TJ, Lukacs NW, Kunkel SL, Chensue SW, Lu B, Gerard CJ, Hogaboam CM. 2000. Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease. J Immunol 165:1564-1572.

Hogaboam CM, Blease K, Mehrad B, Steinhauser ML, Standiford TJ, Kunkel SL, Lukacs NW. 2000. Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am J Pathol 156:723-732.

Mehrad B, Moore TA, Standiford TJ. 2000. Macrophage inflammatory protein-1 alpha is a critical mediator of host defense against invasive pulmonary aspergillosis in neutropenic hosts. J Immunol 165:962-968.

Moore TA, Newstead MW, Strieter RM, Mehrad B, Beaman BL, Standiford TJ. 2000. Bacterial clearance and survival are dependent on CXC chemokine receptor-2 ligands in a murine model of pulmonary Nocardia asteroides infection. J Immunol 164:908-915.

Tsai WC, Strieter RM, Mehrad B, Newstead MW, Zeng X, Standiford TJ. 2000. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun 68:4289-4296.

Standiford TJ, Tsai WC, Mehrad B, Moore TA. 2000. Cytokines as targets of immunotherapy in bacterial pneumonia. J Lab Clin Med 135:129-138.

Cerna F, Mehrad B, Luby JP, Burns D, Fleckenstein JL. 1999. St. Louis encephalitis and the substantia nigra: MR imaging evaluation. AJNR Am J Neuroradiol 20:1281-1283.

Standiford TJ, Wilkowski JM, Sisson TH, Hattori N, Mehrad B, Bucknell KA, Moore TA. 1999.

Intrapulmonary tumor necrosis factor gene therapy increases bacterial clearance and survival in murinegram-negative pneumonia. Hum Gene Ther 10:899-909.

Mehrad B, Standiford TJ. 1999. Role of cytokines in pulmonary antimicrobial host defense. Immunol Res 20:15-27.

Mehrad B, Standiford TJ. 1999. Use of Animal Models in the Study of Inflammatory Mediators of Pneumonia. ILAR J 40:167-174.

Mehrad B, Strieter RM, Moore TA, Tsai WC, Lira SA, Standiford TJ. 1999. CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J Immunol 163:6086-6094.

Mehrad B, Strieter RM, Standiford TJ. 1999. Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. J Immunol 162:1633-1640.

Book Chapters:

Keeley EC, Mehrad B, Strieter RM. Fibrocyte differentiation pathways. In: Fibrocytes in health and disease.  Bucala R (ed). World Scientific Publication Co, Hackensack: 45-52, 2012. .

Mehrad B, Keeley EC, Kolb M, Strieter RM. Fibrocytes in interstitial lung disease. In: Fibrocytes in health and disease. Bucala R (ed). World Scientific Publication Co, Hackensack: 131-142, 2012. .

Keeley EC, Mehrad B, Strieter RM. ELR+ CXC chemokines and their role in malignancy. In: The inflammatory milieu of tumors: cytokines and chemokines that affect tumor growth and metastases. Ben-Baruch A (ed). Bentham Science. 79-85, 2012.