Alexandra Kadl, MD

Alexandra Kadl, MD

Alexandra Kadl

 

 

 

 

 

 

 

Alexandra Kadl, MD

Rank/Position:

Assistant Professor of Medicine

Fellowship:

University of Virginia

Office Address:

P.O. Box 800546

Division of Pulmonary and Critical Care Medicine
University of Virginia Health System
Charlottesville, VA 22908

Phone:

434-924-5210

FAX:

434-924-9682

Board Certifications:

Internal Medicine, Pulmonary Medicine

Email:

ak5sc@virginia.edu

Clinics:

UVA Pulmonary Clinic:  434-924-5219

Clinical Practice:

Critical Care and general pulmonary

Research Interests:

Lung injury and repair, sepsis

Publications (selected):

Juncadella IJ, Kadl A, Sharma AK, Shim YM, Hochreiter-Hufford A, Borish L, Ravichandran KS. Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature. 2013;493:547-551

Kadl A, Sharma PR, Chen W, Agrawal R, Meher AK, Rudraiah S, Grubbs N, Sharma R, Leitinger N. Oxidized phospholipid-induced inflammation is mediated by toll-like receptor 2. Free radical biology & medicine. 2011;51:1903-1909

Kadl A, Meher AK, Sharma PR, Lee MY, Doran AC, Johnstone SR, Elliott MR, Gruber F, Han J, Chen W, Kensler T, Ravichandran KS, Isakson BE, Wamhoff BR, Leitinger N. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via nrf2. Circulation research. 2010;107:737-746

Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E. Nf-e2-related factor 2 regulates the stress response to uva-1-oxidized phospholipids in skin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010;24:39-48

von Schlieffen E, Oskolkova OV, Schabbauer G, Gruber F, Bluml S, Genest M, Kadl A, Marsik C, Knapp S, Chow J, Leitinger N, Binder BR, Bochkov VN. Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids. Arteriosclerosis, thrombosis, and vascular biology. 2009;29:356-362

Kadl A, Galkina E, Leitinger N. Induction of ccr2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation. Arthritis and rheumatism. 2009;60:1362-1371

Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461:282-286

Chung MJ, Kadl A, Zapata H, Verghese G. Toxic Epidermal Necrolysis: A Case Report and  Review of Current Management. UVA Journal of Medicine. 2009 December; (6)

Leonarduzzi G, Gamba P, Gargiulo S, Sottero B, Kadl A, Biasi F, Chiarpotto E, Leitinger N, Vendemiale G, Serviddio G, Poli G. Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: Cd36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture. Aging cell. 2008;7:375-382

Kronke G, Kadl A, Ikonomu E, Bluml S, Furnkranz A, Sarembock IJ, Bochkov VN, Exner M, Binder BR, Leitinger N. Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors. Arteriosclerosis, thrombosis, and vascular biology. 2007;27:1276-1282

Kadl A, Pontiller J, Exner M, Leitinger N. Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock. 2007;28:582-588

Huber J, Loffler M, Bilban M, Reimers M, Kadl A, Todoric J, Zeyda M, Geyeregger R, Schreiner M, Weichhart T, Leitinger N, Waldhausl W, Stulnig TM. Prevention of high-fat diet-induced adipose tissue remodeling in obese diabetic mice by n-3 polyunsaturated fatty acids. International journal of obesity. 2007;31:1004-1013

Gruber F, Oskolkova O, Leitner A, Mildner M, Mlitz V, Lengauer B, Kadl A, Mrass P, Kronke G, Binder BR, Bochkov VN, Leitinger N, Tschachler E. Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells. The Journal of biological chemistry. 2007;282:16934-16941

Kadl A, Leitinger N. VEGF therapy: risky business for established plaques? Blood. 2007;109: 2-3

Todoric J, Loffler M, Huber J, Bilban M, Reimers M, Kadl A, Zeyda M, Waldhausl W, Stulnig TM. Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Diabetologia. 2006;49:2109-2119

Lucerna M, Pomyje J, Mechtcheriakova D, Kadl A, Gruber F, Bilban M, Sobanov Y, Schabbauer G, Breuss J, Wagner O, Bischoff M, Clauss M, Binder BR, Hofer E. Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth. Cancer research. 2006;66:6708-6713

Isakson BE, Kronke G, Kadl A, Leitinger N, Duling BR. Oxidized phospholipids alter vascular connexin expression, phosphorylation, and heterocellular communication. Arteriosclerosis, thrombosis, and vascular biology. 2006;26:2216-2221

Galkina E, Kadl A, Sanders J, Varughese D, Sarembock IJ, Ley K. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially l-selectin dependent. The Journal of experimental medicine. 2006;203:1273-1282

Bochkov VN, Philippova M, Oskolkova O, Kadl A, Furnkranz A, Karabeg E, Afonyushkin T, Gruber F, Breuss J, Minchenko A, Mechtcheriakova D, Hohensinner P, Rychli K, Wojta J, Resink T, Erne P, Binder BR, Leitinger N. Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions. Circulation research. 2006;99:900-908

Leonarduzzi G, Gamba P, Sottero B, Kadl A, Robbesyn F, Calogero RA, Biasi F, Chiarpotto E, Leitinger N, Sevanian A, Poli G. Oxysterol-induced up-regulation of mcp-1 expression and synthesis in macrophage cells. Free radical biology & medicine. 2005;39:1152-1161

Kadl A, Leitinger N. The role of endothelial cells in the resolution of acute inflammation. Antioxidants & redox signaling. 2005;7:1744-1754

Furnkranz A, Schober A, Bochkov VN, Bashtrykov P, Kronke G, Kadl A, Binder BR, Weber C, Leitinger N. Oxidized phospholipids trigger atherogenic inflammation in murine arteries. Arteriosclerosis, thrombosis, and vascular biology. 2005;25:633-638

Kadl A, Bochkov VN, Huber J, Leitinger N. Apoptotic cells as sources for biologically active oxidized phospholipids. Antioxidants & redox signaling. 2004;6:311-320

Lucerna M, Mechtcheriakova D, Kadl A, Schabbauer G, Schafer R, Gruber F, Koshelnick Y, Muller HD, Issbrucker K, Clauss M, Binder BR, Hofer E. Nab2, a corepressor of egr-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. The Journal of biological chemistry. 2003;278:11433-11440

Kronke G, Bochkov VN, Huber J, Gruber F, Bluml S, Furnkranz A, Kadl A, Binder BR, Leitinger N. Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of camp-responsive element-binding protein. The Journal of biological chemistry. 2003;278:51006-51014

Kadl A, Huber J, Gruber F, Bochkov VN, Binder BR, Leitinger N. Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time rt-pcr in comparison with effects of lps. Vascular pharmacology. 2002;38:219-227

Breuss JM, Cejna M, Bergmeister H, Kadl A, Baumgartl G, Steurer S, Xu Z, Koshelnick Y, Lipp J, De Martin R, Losert U, Lammer J, Binder BR. Activation of nuclear factor-kappa b significantly contributes to lumen loss in a rabbit iliac artery balloon angioplasty model. Circulation. 2002;105:633-638

Bochkov VN, Kadl A, Huber J, Gruber F, Binder BR, Leitinger N. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature. 2002;419:77-81