Gilbert R. Kinsey, PharmD, PhD

Gilbert R. Kinsey, PharmD, PhD

Bert Kinsey

Assistant Professor of Medicine

Degree(s):  Pharm.D., Ph.D.
Graduate School: Medical University of South Carolina
Research Interests: Acute Kidney Injury, Regulatory T Cells, Innate Immune Response

434-924-9637 | Fax 434-924-5848 | grk4n@virginia.edu

The goal of our laboratory is to develop treatments that will either prevent or treat acute kidney injury (AKI). AKI by itself is detrimental in terms of morbidity and mortality and increases the likelihood of chronic and end-stage renal disease. An uncontrolled immune response (inflammation) in the injured kidney is a common mechanism leading to AKI. Our recent studies have demonstrated that anti-inflammatory cells of the immune system called regulatory T cells (Tregs) protect the kidney from AKI in an animal model. We are currently exploring the mechanisms used by Tregs to protect the kidney with the intention of discovering or developing therapies that mimic the beneficial actions of Tregs in kidney injury.

References
PubMed Search for articles by faculty member »

Kinsey GR, Sharma R, Huang L, Li L, Vergis AL, Ye H, Ju ST and Okusa MD.  Regulatory T cells suppress innate immunity in kidney ischemia reperfusion injury. Journal of the American Society of Nephrology. 2009 20(8):1744-1753.

Kinsey GR, Huang L, Vergis AL, Li L and Okusa MD. Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney. Kidney International. 2010 77(9):771-780.

Kinsey GR and Okusa MD. Pathogenesis of acute kidney injury: foundation for clinical practice. American Journal of Kidney Diseases. 2011 58(2):291-301.

Kinsey GR, Huang L, Jaworska K, Khutsishvili K, Becker DA, Ye H, Lobo PI, Okusa MD. Autocrine Adenosine Signaling Promotes Regulatory T Cell-Mediated Renal Protection. Journal of the American Society of Nephrology. 2012 Jul 26.