Jitendra K. Gautam, PhD
Graduate School: Institute of Microbial Technology, Chandigarh, India
Primary Appointment: Assistant Professor, Medicine, Nephrology
Immune System Modulation
Email Address: email@example.com
Inflammation is believed to be the key for the initiation of various diseases including autoimmune processes like glomerulonephritis. Toll Like Receptors (TLRs), which form the backbone of the innate immune system, are the critical first responders in the initiation of the inflammatory response. Their role becomes even more relevant with the knowledge that the innate immune system even instructs the adaptive immune response. TLRs are pattern recognition receptors (PRR), recognizing conserved molecular patterns. Several endogenous and exogenous ligands in the inflammatory processes of various renal diseases have been described. Studying molecular mechanisms of the TLR signaling in relationship to renal disease is the focus of my research. Previously we have described the crucial amino acids needed for signaling of TLR2/1 and have proposed a model for their interaction, which now has been well validated by other investigators. Using our TLR signaling expertise we are working on designing ways to modulate the immune system for beneficial effects in controverting the development of autoimmune glomerulonephritis.
Sharma MK, Singh NK, Jani D, Sisodia R, Thungapathra M, Gautam JK, Meena LS, Singh Y, Ghosh A, Tyagi AK, Sharma AK. Expression of toxin co-regulated pilus subunit A (TCPA) of Vibrio cholerae and its immunogenic epitopes fused to cholera toxin B subunit in transgenic tomato (Solanum lycopersicum). Plant Cell Rep. 2008 (2):307-18. 2007.
Gautam JK, Ashish, Comeau LD, Krueger JK, Smith MF Jr. Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling. J Biol Chem. 2006; 281: 30132-42.
Smith MF Jr, Gautam JK, Black SG, Ernst PB. Microbial-induced regulation of syndecan expression: important host defense mechanism or an opportunity for pathogens? ScientificWorldJournal. 2006; 6:442-5.
Carl VS, Gautam JK, Comeau LD, Smith MF Jr. Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression. J Leukoc Biol. 2004; 76(3):735-42. 2004.